U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    l3mbtl1b L3MBTL histone methyl-lysine binding protein 1b [ Danio rerio (zebrafish) ]

    Gene ID: 559572, updated on 12-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    l3mbtl1bprovided by ZNC
    Official Full Name
    L3MBTL histone methyl-lysine binding protein 1bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-100922-38
    See related
    Ensembl:ENSDARG00000074346 AllianceGenome:ZFIN:ZDB-GENE-100922-38
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:dkey-108f8.2
    Summary
    Predicted to enable chromatin binding activity and histone binding activity. Predicted to be involved in negative regulation of transcription, DNA-templated. Predicted to act upstream of or within chromatin organization and regulation of transcription, DNA-templated. Predicted to be active in nucleus. Orthologous to human L3MBTL1 (L3MBTL histone methyl-lysine binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See l3mbtl1b in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (26509350..26528139, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (26637108..26654741, complement)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene erythrocyte membrane protein band 4.1b Neighboring gene nucleolar protein 58-like Neighboring gene serum/glucocorticoid regulated kinase 2b Neighboring gene protein tyrosine phosphatase non-receptor type 3

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Expanding CRISPR/Cas9 Genome Editing Capacity in Zebrafish Using SaCas9. Feng Y, et al. G3 (Bethesda), 2016 Aug 9. PMID 27317783, Free PMC Article
    2. Concomitant duplications of opioid peptide and receptor genes before the origin of jawed vertebrates. Sundström G, et al. PLoS One, 2010 May 6. PMID 20463905, Free PMC Article
    3. A network of epigenetic regulators guides developmental haematopoiesis in vivo. Huang HT, et al. Nat Cell Biol, 2013 Dec. PMID 24240475, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    lethal(3)malignant brain tumor-like protein 4
    Names
    L3MBTL1, histone methyl-lysine binding protein b
    l(3)mbt-like 1b

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      26509350..26528139 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_682928.10 → XP_688020.5  lethal(3)malignant brain tumor-like protein 4 isoform X1

      See identical proteins and their annotated locations for XP_688020.5

      UniProtKB/TrEMBL
      A0A8N7TAT4, E9QEX7, F1QWE7
      Related
      ENSDARP00000101801.3, ENSDART00000110260.4
      Conserved Domains (4) summary
      cd09582
      Location:716 → 781
      SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group
      smart00454
      Location:716 → 781
      SAM; Sterile alpha motif
      smart00561
      Location:452 → 544
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
      pfam01530
      Location:557 → 584
      zf-C2HC; Zinc finger, C2HC type

    2. XM_009292356.4 → XP_009290631.1  lethal(3)malignant brain tumor-like protein 4 isoform X2

      UniProtKB/TrEMBL
      A0A8M3AQL9
      Conserved Domains (4) summary
      cd09582
      Location:710 → 775
      SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group
      smart00454
      Location:710 → 775
      SAM; Sterile alpha motif
      smart00561
      Location:452 → 544
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
      pfam01530
      Location:557 → 578
      zf-C2HC; Zinc finger, C2HC type

    3. XM_009292357.4 → XP_009290632.1  lethal(3)malignant brain tumor-like protein 4 isoform X1

      See identical proteins and their annotated locations for XP_009290632.1

      UniProtKB/TrEMBL
      A0A8N7TAT4, E9QEX7, F1QWE7
      Related
      ENSDARP00000121747.1, ENSDART00000134448.3
      Conserved Domains (4) summary
      cd09582
      Location:716 → 781
      SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group
      smart00454
      Location:716 → 781
      SAM; Sterile alpha motif
      smart00561
      Location:452 → 544
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
      pfam01530
      Location:557 → 584
      zf-C2HC; Zinc finger, C2HC type

    4. XM_068214140.1 → XP_068070241.1  lethal(3)malignant brain tumor-like protein 4 isoform X1

    RNA

    1. XR_002455794.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.