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    dennd4c DENN/MADD domain containing 4C [ Danio rerio (zebrafish) ]

    Gene ID: 558626, updated on 28-Oct-2024

    Summary

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    Official Symbol
    dennd4cprovided by ZNC
    Official Full Name
    DENN/MADD domain containing 4Cprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-120727-13
    See related
    Ensembl:ENSDARG00000102766 AllianceGenome:ZFIN:ZDB-GENE-120727-13
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of Rab protein signal transduction. Predicted to be part of ESCRT I complex. Predicted to be active in cytoplasmic vesicle. Orthologous to human DENND4C (DENN domain containing 4C). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See dennd4c in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (59068868..59156170, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (58766438..58853983, complement)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene FAST kinase domains 3 Neighboring gene uncharacterized LOC110439910 Neighboring gene charged multivesicular body protein 5b Neighboring gene small Cajal body-specific RNA 8 Neighboring gene HAUS augmin-like complex, subunit 6 Neighboring gene oligosaccharyltransferase complex subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of Rab protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of ESCRT I complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DENN domain-containing protein 4C
    Names
    unm_sa1910

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      59068868..59156170 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001919955.8 → XP_001919990.2  DENN domain-containing protein 4C isoform X2

      UniProtKB/TrEMBL
      A0A0R4IIC4, A0A8M1QKD6
      Related
      ENSDARP00000144352.1, ENSDART00000175438.2
      Conserved Domains (6) summary
      smart00801
      Location:557 → 630
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:190 → 273
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      sd00004
      Location:819 → 848
      PPR; PPR repeat [structural motif]
      pfam02141
      Location:307 → 490
      DENN; DENN (AEX-3) domain
      pfam10240
      Location:40 → 205
      DUF2464; Protein of unknown function (DUF2464)
      pfam13041
      Location:818 → 857
      PPR_2; PPR repeat family

    2. XM_005166553.5 → XP_005166610.1  DENN domain-containing protein 4C isoform X1

      UniProtKB/TrEMBL
      A0A8M2BE44
      Conserved Domains (6) summary
      smart00801
      Location:557 → 630
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:190 → 273
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      sd00004
      Location:819 → 848
      PPR; PPR repeat [structural motif]
      pfam02141
      Location:307 → 490
      DENN; DENN (AEX-3) domain
      pfam10240
      Location:40 → 205
      DUF2464; Protein of unknown function (DUF2464)
      pfam13041
      Location:818 → 857
      PPR_2; PPR repeat family
    Nucleotide Protein Strain
    Heading Accession and Version

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