kmt2a lysine (K)-specific methyltransferase 2A [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: kmt2aprovided by ZNC
Official Full Name: lysine (K)-specific methyltransferase 2Aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-080521-3
See related: Ensembl:ENSDARG00000004537 AllianceGenome:ZFIN:ZDB-GENE-080521-3
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: mll; im:7148357
Summary: Predicted to enable histone methyltransferase activity (H3-K4 specific). Acts upstream of or within glial cell development; nucleate erythrocyte development; and paraxial mesoderm development. Predicted to be located in nucleus. Predicted to be part of histone methyltransferase complex. Is expressed in several structures, including blastoderm; blastodisc; intermediate cell mass of mesoderm; nervous system; and renal system. Human ortholog(s) of this gene implicated in acute myeloid leukemia; cervical cancer; mixed phenotype acute leukemia; and non-Hodgkin lymphoma. Orthologous to human KMT2A (lysine methyltransferase 2A). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 15

Exon count:: 35

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	15	NC_007126.7 (23379390..23420188, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	15	NC_007126.6 (23444235..23484973, complement)

Chromosome 15 - NC_007126.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

revealed a novel function of Kmt2a in cell proliferation and differentiation
Title: The epigenetic factor Kmt2a/Mll1 regulates neural progenitor proliferation and neuronal and glial differentiation.
Zebrafish mll plays essential roles in hematopoiesis.
Title: Zebrafish mll gene is essential for hematopoiesis.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables histone H3K4 methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone H3K4 methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K4 monomethyltransferase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chromatin organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glial cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within methylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nucleate erythrocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within paraxial mesoderm development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of histone methyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of histone methyltransferase complex	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: histone-lysine N-methyltransferase 2A

Names: mixed-lineage leukemia-like protein; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); myeloid/lymphoid or mixed-lineage leukemia protein

NP_001103749.1

EC 2.1.1.354

XP_005157640.1

EC 2.1.1.354

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001110279.1 → NP_001103749.1 histone-lysine N-methyltransferase 2A

See identical proteins and their annotated locations for NP_001103749.1

Status: PROVISIONAL

Source sequence(s)

EU179544

UniProtKB/TrEMBL

A8VKP8

Related

ENSDARP00000123761.1, ENSDART00000148840.2

Conserved Domains (11) summary

cd05493
Location:1841 → 1971

Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...

smart00542
Location:3918 → 4001

FYRC; FY-rich domain, C-terminal region

smart00317
Location:4080 → 4200

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

smart00508
Location:4202 → 4218

PostSET; Cysteine-rich motif following a subset of SET domains

COG2940
Location:4059 → 4218

SET; SET domain-containing protein (function unknown) [General function prediction only]

pfam02008
Location:1312 → 1359

zf-CXXC; CXXC zinc finger domain

cd15590
Location:1675 → 1724

PHD2_KMT2A; PHD finger 2 found in histone-lysine N-methyltransferase 2A (KMT2A)

cd15592
Location:1762 → 1818

PHD3_KMT2A; PHD finger 3 found in histone-lysine N-methyltransferase 2A (KMT2A)

cd15693
Location:2066 → 2178

ePHD_KMT2A; Extended PHD finger found in histone-lysine N-methyltransferase 2A (KMT2A)

pfam05964
Location:2220 → 2266

FYRN; F/Y-rich N-terminus

cl22851
Location:1627 → 1673

PHD_SF; PHD finger superfamily

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007126.7 Reference GRCz11 Primary Assembly

Range

23379390..23420188 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005157583.4 → XP_005157640.1 histone-lysine N-methyltransferase 2A isoform X1

UniProtKB/TrEMBL

A0A8M2B3W9, F1QL52

Related

ENSDARP00000095298.3, ENSDART00000104525.5

Conserved Domains (11) summary

cd05493
Location:1841 → 1971

Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...

smart00542
Location:3919 → 4002

FYRC; FY-rich domain, C-terminal region

smart00317
Location:4081 → 4201

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

smart00508
Location:4203 → 4219

PostSET; Cysteine-rich motif following a subset of SET domains

COG2940
Location:4060 → 4219

SET; SET domain-containing protein (function unknown) [General function prediction only]

pfam02008
Location:1312 → 1359

zf-CXXC; CXXC zinc finger domain

cd15588
Location:1627 → 1673

PHD1_KMT2A; PHD finger 1 found in histone-lysine N-methyltransferase 2A (KMT2A)

cd15590
Location:1675 → 1724

PHD2_KMT2A; PHD finger 2 found in histone-lysine N-methyltransferase 2A (KMT2A)

cd15592
Location:1762 → 1818

PHD3_KMT2A; PHD finger 3 found in histone-lysine N-methyltransferase 2A (KMT2A)

cd15693
Location:2066 → 2178

ePHD_KMT2A; Extended PHD finger found in histone-lysine N-methyltransferase 2A (KMT2A)

pfam05964
Location:2220 → 2266

FYRN; F/Y-rich N-terminus