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    Btnl2 butyrophilin-like 2 [ Mus musculus (house mouse) ]

    Gene ID: 547431, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Btnl2provided by MGI
    Official Full Name
    butyrophilin-like 2provided by MGI
    Primary source
    MGI:MGI:1859549
    See related
    Ensembl:ENSMUSG00000024340 AllianceGenome:MGI:1859549
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NG9; Btl2; BTLN2; Gm315; BTL-II
    Summary
    Enables signaling receptor binding activity. Acts upstream of or within negative regulation of T cell receptor signaling pathway; positive regulation of T cell proliferation; and positive regulation of interleukin-2 production. Predicted to be located in membrane. Predicted to be active in external side of plasma membrane. Is expressed in intestine and skeletal muscle. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; autoimmune disease (multiple); berylliosis; coronary artery disease; and sarcoidosis. Orthologous to human BTNL2 (butyrophilin like 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in large intestine adult (RPKM 31.7), duodenum adult (RPKM 31.5) and 2 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Btnl2 in Genome Data Viewer
    Location:
    17 B1; 17 17.98 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34573763..34588466)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (34354789..34369492)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8670 Neighboring gene STARR-positive B cell enhancer ABC_E8919 Neighboring gene histocompatibility 2, class II antigen E beta2 Neighboring gene STARR-seq mESC enhancer starr_42429 Neighboring gene STARR-positive B cell enhancer ABC_E769 Neighboring gene histocompatibility 2, class II antigen E alpha Neighboring gene STARR-positive B cell enhancer ABC_E11639 Neighboring gene butyrophilin-like 1 Neighboring gene non-histone chromosomal protein HMG-14-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Butyrophilin-like 2 regulates site-specific adaptations of intestinal γδ intraepithelial lymphocytes. Panea C, et al. Commun Biol, 2021 Jul 26. PMID 34312491, Free PMC Article
    2. Structural Insights into N-terminal IgV Domain of BTNL2, a T Cell Inhibitory Molecule, Suggests a Non-canonical Binding Interface for Its Putative Receptors. Basak AJ, et al. J Mol Biol, 2020 Nov 6. PMID 32976909, Free PMC Article
    3. Cancer cell-expressed BTNL2 facilitates tumour immune escape via engagement with IL-17A-producing γδ T cells. Du Y, et al. Nat Commun, 2022 Jan 11. PMID 35017553, Free PMC Article
    4. Butyrophilin-like 2 modulates B7 costimulation to induce Foxp3 expression and regulatory T cell development in mature T cells. Swanson RM, et al. J Immunol, 2013 Mar 1. PMID 23359506
    5. BTNL2, a butyrophilin/B7-like molecule, is a negative costimulatory molecule modulated in intestinal inflammation. Arnett HA, et al. J Immunol, 2007 Feb 1. PMID 17237401

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cancer cell-expressed BTNL2 facilitates tumour immune escape via engagement with IL-17A-producing gammadelta T cells.
      Title: Cancer cell-expressed BTNL2 facilitates tumour immune escape via engagement with IL-17A-producing γδ T cells.
    2. Butyrophilin-like 2 regulates site-specific adaptations of intestinal gammadelta intraepithelial lymphocytes.
      Title: Butyrophilin-like 2 regulates site-specific adaptations of intestinal γδ intraepithelial lymphocytes.
    3. Structural Insights into N-terminal IgV Domain of BTNL2, a T Cell Inhibitory Molecule, Suggests a Non-canonical Binding Interface for Its Putative Receptors.
      Title: Structural Insights into N-terminal IgV Domain of BTNL2, a T Cell Inhibitory Molecule, Suggests a Non-canonical Binding Interface for Its Putative Receptors.
    4. Butyrophilin-like 2 modulates B7 costimulation to induce Foxp3 expression and regulatory T cell development in mature T cells.
      Title: Butyrophilin-like 2 modulates B7 costimulation to induce Foxp3 expression and regulatory T cell development in mature T cells.
    5. BTNL2 is overexpressed during both the asymptomatic and symptomatic phase of the Mdr1a knockout model of spontaneous colitis. Soluble BTNL2-Fc protein inhibits proliferation of murine T4 cells from the spleen, mesenteric lymph node, and Peyer's patch.
      Title: BTNL2, a butyrophilin/B7-like molecule, is a negative costimulatory molecule modulated in intestinal inflammation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4)  1 citation
    • Targeted (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in T cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of T cell receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of interleukin-2 production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cytokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    butyrophilin-like protein 2
    Names
    butyrophylin-like MHC class II associated

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_079835.2 → NP_524574.1  butyrophilin-like protein 2

      See identical proteins and their annotated locations for NP_524574.1

      Status: VALIDATED

      Source sequence(s)
      AK136521
      Consensus CDS
      CCDS37585.1
      UniProtKB/TrEMBL
      B2RUE4
      Related
      ENSMUSP00000025198.8, ENSMUST00000025198.15
      Conserved Domains (3) summary
      cd05713
      Location:43 → 142
      Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
      smart00410
      Location:257 → 358
      IG_like; Immunoglobulin like
      cl11960
      Location:379 → 444
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      34573763..34588466
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524645.3 → XP_006524708.1  butyrophilin-like protein 2 isoform X2

      See identical proteins and their annotated locations for XP_006524708.1

      Conserved Domains (2) summary
      cd05713
      Location:43 → 142
      Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
      cl11960
      Location:260 → 281
      Ig; Immunoglobulin domain

    2. XM_006524646.1 → XP_006524709.1  butyrophilin-like protein 2 isoform X3

      See identical proteins and their annotated locations for XP_006524709.1

      Conserved Domains (2) summary
      cd05713
      Location:43 → 142
      Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
      cl11960
      Location:260 → 279
      Ig; Immunoglobulin domain

    3. XM_017317579.3 → XP_017173068.1  butyrophilin-like protein 2 isoform X1

      UniProtKB/TrEMBL
      B2RUE4
      Conserved Domains (2) summary
      cd05713
      Location:200 → 298
      Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
      cl11960
      Location:1 → 82
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O70355.2 GenPept UniProtKB/Swiss-Prot:O70355

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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