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    Cacng6 calcium channel, voltage-dependent, gamma subunit 6 [ Mus musculus (house mouse) ]

    Gene ID: 54378, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Cacng6provided by MGI
    Official Full Name
    calcium channel, voltage-dependent, gamma subunit 6provided by MGI
    Primary source
    MGI:MGI:1859168
    See related
    Ensembl:ENSMUSG00000078815 AllianceGenome:MGI:1859168
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2310033H20Rik
    Summary
    Predicted to enable calcium channel regulator activity. Predicted to be involved in regulation of calcium ion transmembrane transport via high voltage-gated calcium channel. Predicted to be part of L-type voltage-gated calcium channel complex. Is expressed in central nervous system; heart; and retina. Human ortholog(s) of this gene implicated in aspirin-induced respiratory disease. Orthologous to human CACNG6 (calcium voltage-gated channel auxiliary subunit gamma 6). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in mammary gland adult (RPKM 5.5), limb E14.5 (RPKM 2.1) and 2 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cacng6 in Genome Data Viewer
    Location:
    7 A1; 7 2.0 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (3472017..3484183)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (3423588..3435667)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene calcium channel, voltage-dependent, gamma subunit 8 Neighboring gene RIKEN cDNA 3300002P13 gene Neighboring gene microRNA 935 Neighboring gene STARR-seq mESC enhancer starr_17905 Neighboring gene predicted gene, 35037 Neighboring gene predicted gene, 45920 Neighboring gene STARR-seq mESC enhancer starr_17907 Neighboring gene T cell-interacting, activating receptor on myeloid cells 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A family of gamma-like calcium channel subunits. Klugbauer N, et al. FEBS Lett, 2000 Mar 24. PMID 10734232
    2. A cluster of three novel Ca2+ channel gamma subunit genes on chromosome 19q13.4: evolution and expression profile of the gamma subunit gene family. Burgess DL, et al. Genomics, 2001 Feb 1. PMID 11170751
    3. Calcium channel gamma subunits provide insights into the evolution of this gene family. Chu PJ, et al. Gene, 2001 Dec 12. PMID 11738816
    4. Patterned expression of ion channel genes in mouse dorsal raphe nucleus determined with the Allen Mouse Brain Atlas. Templin JS, et al. Brain Res, 2012 May 31. PMID 22534482, Free PMC Article
    5. Lem2 is essential for cardiac development by maintaining nuclear integrity. Ross JA, et al. Cardiovasc Res, 2023 Sep 5. PMID 37067297, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study demonistrated that Cacng6 gene expression in mouse dorsal raphe nucleus
      Title: Patterned expression of ion channel genes in mouse dorsal raphe nucleus determined with the Allen Mouse Brain Atlas.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC144251, MGC144252, 2310033H20Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium channel regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of calcium ion transmembrane transport via high voltage-gated calcium channel IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of L-type voltage-gated calcium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of L-type voltage-gated calcium channel complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of L-type voltage-gated calcium channel complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    voltage-dependent calcium channel gamma-6 subunit
    Names
    neuronal voltage-gated calcium channel gamma-6 subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133183.2 → NP_573446.1  voltage-dependent calcium channel gamma-6 subunit

      See identical proteins and their annotated locations for NP_573446.1

      Status: VALIDATED

      Source sequence(s)
      AC217111
      Consensus CDS
      CCDS39726.1
      UniProtKB/Swiss-Prot
      Q8VHW3
      UniProtKB/TrEMBL
      Q14C42, Q14C43
      Related
      ENSMUSP00000138622.2, ENSMUST00000183200.8
      Conserved Domains (1) summary
      cl21598
      Location:47 → 223
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      3472017..3484183
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540200.4 → XP_006540263.1  voltage-dependent calcium channel gamma-6 subunit isoform X1

      See identical proteins and their annotated locations for XP_006540263.1

      UniProtKB/TrEMBL
      A0A0A0MQD3, Q14C43
      Related
      ENSMUSP00000104287.3, ENSMUST00000108647.3
      Conserved Domains (1) summary
      cl21598
      Location:47 → 141
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

    2. XM_036153252.1 → XP_036009145.1  voltage-dependent calcium channel gamma-6 subunit isoform X2

      Conserved Domains (1) summary
      cl21598
      Location:47 → 181
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VHW3.1 GenPept UniProtKB/Swiss-Prot:Q8VHW3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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