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    TCF4 transcription factor 4 [ Bos taurus (domestic cattle) ]

    Gene ID: 534935, updated on 10-Oct-2024

    Summary

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    Official Symbol
    TCF4provided by VGNC
    Official Full Name
    transcription factor 4provided by VGNC
    Primary source
    VGNC:VGNC:35694
    See related
    BGD:BT26851; Ensembl:ENSBTAG00000016462
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    TCF7L2
    Orthologs
    human mouse all
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    Genomic context

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    See TCF4 in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 24 NC_037351.1 (54590672..54976832, complement)

    Chromosome 24 - NC_037351.1Genomic Context describing neighboring genes Neighboring gene microRNA mir-12017 Neighboring gene coiled-coil domain containing 68 Neighboring gene uncharacterized LOC112444148 Neighboring gene U2 spliceosomal RNA Neighboring gene transfer RNA glutamic acid (anticodon UUC) Neighboring gene uncharacterized LOC132343741 Neighboring gene uncharacterized LOC132343795

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037351.1 Chromosome 24 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC128514, MGC155227

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of transcription regulator complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transcription factor 4
    Names
    transcription factor 7-like 2 (T-cell specific, HMG-box)
    transcriptional factor 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034621.2 → NP_001029793.1  transcription factor 4

      See identical proteins and their annotated locations for NP_001029793.1

      Status: PROVISIONAL

      Source sequence(s)
      BC103178
      UniProtKB/TrEMBL
      A0AAA9T3U4, Q3ZBP9
      Related
      ENSBTAP00000030970.2, ENSBTAT00000031006.3
      Conserved Domains (1) summary
      smart00353
      Location:414 → 467
      HLH; helix loop helix domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037351.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      54590672..54976832 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010818907.4 → XP_010817209.2  transcription factor 4 isoform X21

      UniProtKB/TrEMBL
      A0A3Q1LLQ6
      Conserved Domains (1) summary
      smart00353
      Location:572 → 625
      HLH; helix loop helix domain

    2. XM_059880880.1 → XP_059736863.1  transcription factor 4 isoform X1

      UniProtKB/TrEMBL
      A6QPK5

    3. XM_010818903.4 → XP_010817205.2  transcription factor 4 isoform X10

      UniProtKB/TrEMBL
      A0A3Q1LLQ6
      Conserved Domains (1) summary
      smart00353
      Location:570 → 623
      HLH; helix loop helix domain

    4. XM_005224218.5 → XP_005224275.1  transcription factor 4 isoform X7

      UniProtKB/TrEMBL
      A0A3Q1LLQ6
      Conserved Domains (1) summary
      smart00353
      Location:574 → 627
      HLH; helix loop helix domain

    5. XM_024984328.2 → XP_024840096.1  transcription factor 4 isoform X7

      UniProtKB/TrEMBL
      A0A3Q1LLQ6
      Related
      ENSBTAP00000060741.2, ENSBTAT00000071224.2
      Conserved Domains (1) summary
      smart00353
      Location:574 → 627
      HLH; helix loop helix domain

    6. XM_024984323.2 → XP_024840091.1  transcription factor 4 isoform X5

      UniProtKB/TrEMBL
      A0AAA9TF14
      Conserved Domains (1) summary
      smart00353
      Location:545 → 598
      HLH; helix loop helix domain

    7. XM_059880875.1 → XP_059736858.1  transcription factor 4 isoform X2

    8. XM_024984324.2 → XP_024840092.1  transcription factor 4 isoform X6

      UniProtKB/TrEMBL
      A0AAA9TF14
      Conserved Domains (1) summary
      smart00353
      Location:545 → 598
      HLH; helix loop helix domain

    9. XM_024984322.2 → XP_024840090.1  transcription factor 4 isoform X3

      UniProtKB/TrEMBL
      A0A3Q1LLQ6
      Conserved Domains (1) summary
      smart00353
      Location:549 → 602
      HLH; helix loop helix domain

    10. XM_059880876.1 → XP_059736859.1  transcription factor 4 isoform X4

      Related
      ENSBTAP00000094733.1, ENSBTAT00000132218.1

    11. XM_024984330.2 → XP_024840098.1  transcription factor 4 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1LLQ6, A6QPK5
      Conserved Domains (1) summary
      smart00353
      Location:550 → 603
      HLH; helix loop helix domain

    12. XM_059880878.1 → XP_059736861.1  transcription factor 4 isoform X11

    13. XM_024984326.2 → XP_024840094.1  transcription factor 4 isoform X8

      UniProtKB/TrEMBL
      A0A3Q1LLQ6
      Related
      ENSBTAP00000081148.1, ENSBTAT00000095949.1
      Conserved Domains (1) summary
      smart00353
      Location:573 → 626
      HLH; helix loop helix domain

    14. XM_059880879.1 → XP_059736862.1  transcription factor 4 isoform X12

    15. XM_024984327.2 → XP_024840095.1  transcription factor 4 isoform X9

      UniProtKB/TrEMBL
      A0A3Q1LLQ6
      Conserved Domains (1) summary
      smart00353
      Location:573 → 626
      HLH; helix loop helix domain

    16. XM_059880877.1 → XP_059736860.1  transcription factor 4 isoform X10

      Related
      ENSBTAP00000103376.1, ENSBTAT00000116007.1

    17. XM_024984325.2 → XP_024840093.1  transcription factor 4 isoform X7

      UniProtKB/TrEMBL
      A0A3Q1LLQ6
      Conserved Domains (1) summary
      smart00353
      Location:574 → 627
      HLH; helix loop helix domain

    18. XM_005224224.5 → XP_005224281.1  transcription factor 4 isoform X1

      See identical proteins and their annotated locations for XP_005224281.1

      UniProtKB/TrEMBL
      A0A3Q1LLQ6, A6QPK5
      Related
      ENSBTAP00000030974.4, ENSBTAT00000031010.6
      Conserved Domains (1) summary
      smart00353
      Location:550 → 603
      HLH; helix loop helix domain

    19. XM_024984329.2 → XP_024840097.1  transcription factor 4 isoform X13

      UniProtKB/TrEMBL
      A0A3Q1LLQ6
      Conserved Domains (1) summary
      smart00353
      Location:558 → 611
      HLH; helix loop helix domain

    20. XM_005224227.5 → XP_005224284.1  transcription factor 4 isoform X14

      See identical proteins and their annotated locations for XP_005224284.1

      UniProtKB/TrEMBL
      A0AAA9TDH2
      Conserved Domains (1) summary
      smart00353
      Location:444 → 497
      HLH; helix loop helix domain

    21. XM_024984331.2 → XP_024840099.1  transcription factor 4 isoform X15

      UniProtKB/TrEMBL
      A0AAA9TDH2
      Conserved Domains (1) summary
      smart00353
      Location:440 → 493
      HLH; helix loop helix domain

    22. XM_005224229.5 → XP_005224286.1  transcription factor 4 isoform X14

      See identical proteins and their annotated locations for XP_005224286.1

      UniProtKB/TrEMBL
      A0AAA9TDH2
      Related
      ENSBTAP00000094816.1, ENSBTAT00000133381.1
      Conserved Domains (1) summary
      smart00353
      Location:444 → 497
      HLH; helix loop helix domain

    23. XM_005224228.5 → XP_005224285.1  transcription factor 4 isoform X14

      See identical proteins and their annotated locations for XP_005224285.1

      UniProtKB/TrEMBL
      A0AAA9TDH2
      Conserved Domains (1) summary
      smart00353
      Location:444 → 497
      HLH; helix loop helix domain

    24. XM_059880881.1 → XP_059736864.1  transcription factor 4 isoform X14

    25. XM_024984335.2 → XP_024840103.1  transcription factor 4 isoform X18

      UniProtKB/TrEMBL
      A0AAA9T3U4
      Conserved Domains (1) summary
      smart00353
      Location:409 → 462
      HLH; helix loop helix domain

    26. XM_010818908.4 → XP_010817210.1  transcription factor 4 isoform X16

      UniProtKB/TrEMBL
      A0AAA9T3U4
      Conserved Domains (1) summary
      smart00353
      Location:413 → 466
      HLH; helix loop helix domain

    27. XM_005224230.5 → XP_005224287.1  transcription factor 4 isoform X17

      UniProtKB/TrEMBL
      A0AAA9T3U4
      Conserved Domains (1) summary
      smart00353
      Location:410 → 463
      HLH; helix loop helix domain

    28. XM_024984336.2 → XP_024840104.1  transcription factor 4 isoform X20

      UniProtKB/TrEMBL
      A0AAA9T3U4
      Conserved Domains (1) summary
      smart00353
      Location:358 → 411
      HLH; helix loop helix domain

    29. XM_059880883.1 → XP_059736866.1  transcription factor 4 isoform X20

    30. XM_059880882.1 → XP_059736865.1  transcription factor 4 isoform X19

    Nucleotide Protein Strain
    Heading Accession and Version

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