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    DUSP13B dual specificity phosphatase 13B [ Homo sapiens (human) ]

    Gene ID: 51207, updated on 2-Nov-2024

    Summary

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    Official Symbol
    DUSP13Bprovided by HGNC
    Official Full Name
    dual specificity phosphatase 13Bprovided by HGNC
    Primary source
    HGNC:HGNC:19681
    See related
    Ensembl:ENSG00000079393 MIM:613191; AllianceGenome:HGNC:19681
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MDSP; TMDP; SKRP4; DUSP13
    Summary
    Members of the protein-tyrosine phosphatase superfamily cooperate with protein kinases to regulate cell proliferation and differentiation. This gene encodes a dual specificity phosphatase that acts on both phosphotyrosine and phosphoserine/threonine residues. The encoded protein is expressed in testis. [provided by RefSeq, Mar 2023]
    Expression
    Biased expression in testis (RPKM 6.3), heart (RPKM 1.5) and 3 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See DUSP13B in Genome Data Viewer
    Location:
    10q22.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (75094434..75109191, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (75967932..75982690, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (76854192..76868949, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3605 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3606 Neighboring gene dual specificity phosphatase 29 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:76817979-76818530 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:76829139-76829638 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:76836023-76836606 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr10:76839152-76839713 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr10:76839714-76840274 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:76842102-76842602 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:76844610-76845110 Neighboring gene peptidylprolyl isomerase A pseudogene 13 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:76863200-76864044 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:76864045-76864889 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:76865735-76866578 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:76870224-76871173 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:76871174-76872122 Neighboring gene sterile alpha motif domain containing 8 Neighboring gene dual specificity phosphatase 13A Neighboring gene uncharacterized LOC124902460 Neighboring gene ribosomal protein S26 pseudogene 42

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of human TMDP, a testis-specific dual specificity protein phosphatase: implications for substrate specificity. Kim SJ, et al. Proteins, 2007 Jan 1. PMID 17044055
    2. Overexpression of dual-specificity phosphatases 4 and 13 attenuates transforming growth factor β1-induced migration and drug resistance in A549 cells in vitro. Guler S, et al. Biochem Biophys Res Commun, 2022 May 28. PMID 35338857
    3. DUSP13B/TMDP inhibits stress-activated MAPKs and suppresses AP-1-dependent gene expression. Katagiri C, et al. Mol Cell Biochem, 2011 Jun. PMID 21360282
    4. Systemic analysis identifying PVT1/DUSP13 axis for microvascular invasion in hepatocellular carcinoma. Su R, et al. Cancer Med, 2023 Apr. PMID 36524545, Free PMC Article
    5. Molecular cloning and characterization of a novel dual-specificity protein phosphatase possibly involved in spermatogenesis. Nakamura K, et al. Biochem J, 1999 Dec 15. PMID 10585869, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Systemic analysis identifying PVT1/DUSP13 axis for microvascular invasion in hepatocellular carcinoma.
      Title: Systemic analysis identifying PVT1/DUSP13 axis for microvascular invasion in hepatocellular carcinoma.
    2. Overexpression of dual-specificity phosphatases 4 and 13 attenuates transforming growth factor beta1-induced migration and drug resistance in A549 cells in vitro.
      Title: Overexpression of dual-specificity phosphatases 4 and 13 attenuates transforming growth factor β1-induced migration and drug resistance in A549 cells in vitro.
    3. data suggest an important role for DUSP13B in protection from external stress during spermatogenesis
      Title: DUSP13B/TMDP inhibits stress-activated MAPKs and suppresses AP-1-dependent gene expression.
    4. Observational study of gene-disease association. (HuGE Navigator)
      Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
    5. Here, we report the crystal structure of human TMDP at a resolution of 2.4 A. In spite of high sequence similarity with other DSPs, the crystal structure of TMDP shows distinct structural motifs and surface propertie
      Title: Crystal structure of human TMDP, a testis-specific dual specificity protein phosphatase: implications for substrate specificity.
    6. identified a gene on chromosome 10q22.2 using alternative ORFs to encode two distinct DSPs: the testis and skeletal muscle-specific TMDP and a novel muscle-restricted DSP(MDSP)
      Title: Characterization of two distinct dual specificity phosphatases encoded in alternative open reading frames of a single gene located on human chromosome 10q22.2.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ32450

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables MAP kinase phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine/serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in dephosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in meiotic cell cycle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatogenesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    dual specificity protein phosphatase 13B
    Names
    Testis- and skeletal muscle-specific DUSP
    dual specificity phosphatase 13
    testis- and skeletal-muscle-specific DSP
    NP_001007273.1
    NP_001007274.1
    NP_001307771.1
    NP_001307772.1
    NP_001350443.1
    NP_001399156.1
    NP_057448.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033976.1 RefSeqGene

      Range
      14701..19777
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001007272.2 → NP_001007273.1  dual specificity protein phosphatase 13B isoform 2

      See identical proteins and their annotated locations for NP_001007273.1

      Status: REVIEWED

      Description
      Transcript Variant: TThis variant (2) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region, compared to variant 9. The encoded isoform (2, also called TMDP-L2) has an alternate N-terminus, compared to isoform 9. Efforts to detect expression of isoform 2 were unsuccessful.
      Source sequence(s)
      AI971328, AK127886, AY674051
      Consensus CDS
      CCDS31224.1
      UniProtKB/TrEMBL
      U3KQA1
      Conserved Domains (1) summary
      cd00127
      Location:95 → 238
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

    2. NM_001007273.2 → NP_001007274.1  dual specificity protein phosphatase 13B isoform 3 precursor

      See identical proteins and their annotated locations for NP_001007274.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region, compared to variant 9. The encoded isoform (3, also called TMDP-L1) has an alternate N-terminus, compared to isoform 9. Efforts to detect expression of isoform 3 were unsuccessful. Both variants 3 and 7 encode the same isoform (3).
      Source sequence(s)
      AI971328, AK127886, AY674051, BU580940
      UniProtKB/TrEMBL
      A0A9L9PXN7
      Related
      ENSP00000516748.1, ENST00000707120.1
      Conserved Domains (1) summary
      cd00127
      Location:138 → 281
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

    3. NM_001320842.2 → NP_001307771.1  dual specificity protein phosphatase 13B isoform 3 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region, compared to variant 9. The encoded isoform (3, also known as TMDP-L1) has an alternate N-terminus, compared to isoform 9. Both variants 3 and 7 encode the same isoform (3).
      Source sequence(s)
      AI971328, AK127886, AY674051
      UniProtKB/TrEMBL
      A0A9L9PXN7
      Conserved Domains (1) summary
      cd00127
      Location:138 → 281
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

    4. NM_001320843.2 → NP_001307772.1  dual specificity protein phosphatase 13B isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region, compared to variant 9. The encoded isoform (6, also known as TMDP) has a shorter N-terminus, compared to isoform 9. Both variants 6 and 8 encode the same isoform (6).
      Source sequence(s)
      AI971328, AK057012, AY674051, DA898973
      Consensus CDS
      CCDS7346.1
      UniProtKB/Swiss-Prot
      A0A024QZR6, A8K776, A8K782, B3KPY1, B3KXT0, B4DUK0, Q5JSC6, Q6IAR0, Q96GC2, Q9UII6, U3KQ82
      UniProtKB/TrEMBL
      U3KQA1
      Related
      ENSP00000516749.1, ENST00000707121.1
      Conserved Domains (1) summary
      cd14577
      Location:28 → 191
      DUSP13B; dual specificity protein phosphatase 13 isoform B

    5. NM_001363514.2 → NP_001350443.1  dual specificity protein phosphatase 13B isoform 9

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) represents the allele encoded by the GRCh38 reference genome and encodes isoform 9.
      Source sequence(s)
      AL392111
      Consensus CDS
      CCDS86105.1
      Related
      ENSP00000475626.1, ENST00000478873.7
      Conserved Domains (1) summary
      cd00127
      Location:181 → 324
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

    6. NM_001412227.1 → NP_001399156.1  dual specificity protein phosphatase 13B isoform 10

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) uses the same exon combination as variant 9 but represents the allele encoded by the T2T-CHM13v2.0 genome assembly. The encoded isoform (10) has a shorter N-terminus due to translation initiation at a downstream start codon, compared to isoform 9.
      Source sequence(s)
      CP068268

    7. NM_016364.3 → NP_057448.3  dual specificity protein phosphatase 13B isoform 6

      See identical proteins and their annotated locations for NP_057448.3

      Status: REVIEWED

      Description
      Transcript Variant: TThis variant (6) uses a downstream in-frame start codon, compared to variant 9. The encoded isoform (6, also called TMDP) has a shorter N-terminus, compared to isoform 9. Both variants 6 and 8 encode the same isoform (6).
      Source sequence(s)
      AB027004
      Consensus CDS
      CCDS7346.1
      UniProtKB/Swiss-Prot
      A0A024QZR6, A8K776, A8K782, B3KPY1, B3KXT0, B4DUK0, Q5JSC6, Q6IAR0, Q96GC2, Q9UII6, U3KQ82
      UniProtKB/TrEMBL
      U3KQA1
      Related
      ENSP00000444580.1, ENST00000472493.6
      Conserved Domains (1) summary
      cd14577
      Location:28 → 191
      DUSP13B; dual specificity protein phosphatase 13 isoform B

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      75094434..75109191 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      75967932..75982690 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001007274.1: Suppressed sequence

      Description
      NM_001007274.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

    2. NM_001007275.1: Suppressed sequence

      Description
      NM_001007275.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UII6.3 GenPept UniProtKB/Swiss-Prot:Q9UII6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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