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    Keap1 kelch-like ECH-associated protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 50868, updated on 28-Oct-2024

    Summary

    Official Symbol
    Keap1provided by MGI
    Official Full Name
    kelch-like ECH-associated protein 1provided by MGI
    Primary source
    MGI:MGI:1858732
    See related
    Ensembl:ENSMUSG00000003308 AllianceGenome:MGI:1858732
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    INRF2; mKIAA0132
    Summary
    Enables disordered domain specific binding activity and identical protein binding activity. Involved in several processes, including cellular response to oxidative stress; protein ubiquitination; and ubiquitin-dependent protein catabolic process. Acts upstream of or within several processes, including cellular response to interleukin-4; in utero embryonic development; and regulation of epidermal cell differentiation. Located in actin filament; endoplasmic reticulum; and inclusion body. Part of Cul3-RING ubiquitin ligase complex. Is expressed in eye and limb mesenchyme. Human ortholog(s) of this gene implicated in gallbladder cancer. Orthologous to human KEAP1 (kelch like ECH associated protein 1). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 41.2), adrenal adult (RPKM 36.0) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Keap1 in Genome Data Viewer
    Location:
    9 A3; 9 7.74 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (21141026..21150628, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (21229730..21239332, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36118 Neighboring gene predicted gene, 35977 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:20966019-20966202 Neighboring gene predicted gene, 39301 Neighboring gene phosphodiesterase 4A, cAMP specific Neighboring gene STARR-positive B cell enhancer ABC_E1781 Neighboring gene STARR-seq mESC enhancer starr_23485 Neighboring gene predicted gene, 16754 Neighboring gene STARR-seq mESC enhancer starr_23486 Neighboring gene STARR-positive B cell enhancer ABC_E8278 Neighboring gene sphingosine-1-phosphate receptor 5 Neighboring gene STARR-positive B cell enhancer mm9_chr9:21069491-21069792 Neighboring gene autophagy related 4D, cysteine peptidase Neighboring gene KRI1 homolog

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in cellular response to carbohydrate stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to interleukin-4 IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to oxidative stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of autophagy IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of epidermal cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of Cul3-RING ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of Cul3-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Cul3-RING ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in actin filament IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in adherens junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centriolar satellite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in inclusion body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in inclusion body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in midbody IEA
    Inferred from Electronic Annotation
    more info
     
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    kelch-like ECH-associated protein 1
    Names
    NRF2 cytosolic inhibitor
    cytosolic inhibitor of Nrf2
    ring canal protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110305.1NP_001103775.1  kelch-like ECH-associated protein 1

      See identical proteins and their annotated locations for NP_001103775.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses a different splice site in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 all encode the same protein.
      Source sequence(s)
      AC163637, AK150485, AK159858, BY586021
      Consensus CDS
      CCDS22897.1
      UniProtKB/Swiss-Prot
      Q3U243, Q3U8N7, Q547S3, Q6ZQI6, Q8BQY3, Q9Z2X8
      Related
      ENSMUSP00000062467.5, ENSMUST00000049567.10
      Conserved Domains (5) summary
      smart00612
      Location:471517
      Kelch; Kelch domain
      PHA03098
      Location:95596
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:460503
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:67176
      BTB; BTB/POZ domain
      pfam07707
      Location:184286
      BACK; BTB And C-terminal Kelch
    2. NM_001110306.1NP_001103776.1  kelch-like ECH-associated protein 1

      See identical proteins and their annotated locations for NP_001103776.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses a different splice site in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 all encode the same protein.
      Source sequence(s)
      AC163637, AK004738, BY586021, CJ179527
      Consensus CDS
      CCDS22897.1
      UniProtKB/Swiss-Prot
      Q3U243, Q3U8N7, Q547S3, Q6ZQI6, Q8BQY3, Q9Z2X8
      Related
      ENSMUSP00000141840.2, ENSMUST00000193982.2
      Conserved Domains (5) summary
      smart00612
      Location:471517
      Kelch; Kelch domain
      PHA03098
      Location:95596
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:460503
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:67176
      BTB; BTB/POZ domain
      pfam07707
      Location:184286
      BACK; BTB And C-terminal Kelch
    3. NM_001110307.1NP_001103777.1  kelch-like ECH-associated protein 1

      See identical proteins and their annotated locations for NP_001103777.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses a different splice site in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 all encode the same protein.
      Source sequence(s)
      AK004738, BY586021
      Consensus CDS
      CCDS22897.1
      UniProtKB/Swiss-Prot
      Q3U243, Q3U8N7, Q547S3, Q6ZQI6, Q8BQY3, Q9Z2X8
      Related
      ENSMUSP00000141807.2, ENSMUST00000194542.6
      Conserved Domains (5) summary
      smart00612
      Location:471517
      Kelch; Kelch domain
      PHA03098
      Location:95596
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:460503
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:67176
      BTB; BTB/POZ domain
      pfam07707
      Location:184286
      BACK; BTB And C-terminal Kelch
    4. NM_016679.4NP_057888.1  kelch-like ECH-associated protein 1

      See identical proteins and their annotated locations for NP_057888.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1, 2, 3, and 4 all encode the same protein.
      Source sequence(s)
      AC163637, AK076234, BY586021
      Consensus CDS
      CCDS22897.1
      UniProtKB/Swiss-Prot
      Q3U243, Q3U8N7, Q547S3, Q6ZQI6, Q8BQY3, Q9Z2X8
      Related
      ENSMUSP00000131029.2, ENSMUST00000164812.8
      Conserved Domains (5) summary
      smart00612
      Location:471517
      Kelch; Kelch domain
      PHA03098
      Location:95596
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:460503
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:67176
      BTB; BTB/POZ domain
      pfam07707
      Location:184286
      BACK; BTB And C-terminal Kelch

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      21141026..21150628 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)