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    Fbxl17 F-box and leucine-rich repeat protein 17 [ Mus musculus (house mouse) ]

    Gene ID: 50758, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Fbxl17provided by MGI
    Official Full Name
    F-box and leucine-rich repeat protein 17provided by MGI
    Primary source
    MGI:MGI:1354704
    See related
    Ensembl:ENSMUSG00000023965 AllianceGenome:MGI:1354704
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fbx13; Fbxo13; 6330576B01Rik; C130023C01Rik
    Summary
    Predicted to be involved in several processes, including entrainment of circadian clock by photoperiod; proteolysis involved in protein catabolic process; and regulation of smoothened signaling pathway. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytosol and nucleus. Is expressed in inferior colliculus; midbrain ventricular layer; and ventral grey horn. Orthologous to human FBXL17 (F-box and leucine rich repeat protein 17). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in frontal lobe adult (RPKM 2.9), cortex adult (RPKM 2.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fbxl17 in Genome Data Viewer
    Location:
    17 E1.1; 17 32.68 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (63352944..63811179, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (63045949..63504184, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene ephrin A5 Neighboring gene predicted gene, 52303 Neighboring gene predicted gene, 46583 Neighboring gene VISTA enhancer mm1538 Neighboring gene STARR-seq mESC enhancer starr_42966 Neighboring gene predicted gene, 34179 Neighboring gene STARR-seq mESC enhancer starr_42967 Neighboring gene predicted gene, 34324 Neighboring gene STARR-seq mESC enhancer starr_42968 Neighboring gene STARR-seq mESC enhancer starr_42969 Neighboring gene predicted gene, 53980 Neighboring gene predicted gene, 24730 Neighboring gene RIKEN cDNA 4930405O22 gene Neighboring gene predicted gene, 41607 Neighboring gene STARR-positive B cell enhancer ABC_E7551 Neighboring gene predicted gene 17228 Neighboring gene predicted gene, 18418 Neighboring gene STARR-seq mESC enhancer starr_42972 Neighboring gene STARR-seq mESC enhancer starr_42973 Neighboring gene peptidylprolyl isomerase A pseudogene 17_1026.1 Neighboring gene mitochondrial pyruvate carrier 2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development. Raducu M, et al. EMBO J, 2016 Jul 1. PMID 27234298, Free PMC Article
    2. A family of mammalian F-box proteins. Winston JT, et al. Curr Biol, 1999 Oct 21. PMID 10531037
    3. Systematic analysis and nomenclature of mammalian F-box proteins. Jin J, et al. Genes Dev, 2004 Nov 1. PMID 15520277, Free PMC Article
    4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    5. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in entrainment of circadian clock by photoperiod IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nervous system development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in neural crest cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein polyubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein quality control for misfolded or incompletely synthesized proteins ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein quality control for misfolded or incompletely synthesized proteins ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of smoothened signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of smoothened signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SCF ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of SCF ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    F-box/LRR-repeat protein 17
    Names
    F-box only protein 13

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015794.1 → NP_056609.1  F-box/LRR-repeat protein 17

      See identical proteins and their annotated locations for NP_056609.1

      Status: VALIDATED

      Source sequence(s)
      AC154192, AF176529, BX515367, CJ179644, CT025670
      Consensus CDS
      CCDS50162.1
      UniProtKB/Swiss-Prot
      B2RRC1, Q8BTC3, Q9QZN1
      Related
      ENSMUSP00000024761.7, ENSMUST00000024761.13
      Conserved Domains (3) summary
      cd09293
      Location:411 → 573
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:362 → 387
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:321 → 368
      F-box-like; F-box-like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      63352944..63811179 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160679.1 → XP_036016572.1  F-box/LRR-repeat protein 17 isoform X1

      Conserved Domains (3) summary
      cd09293
      Location:411 → 573
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:362 → 387
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:321 → 366
      F-box-like

    2. XM_006524600.4 → XP_006524663.1  F-box/LRR-repeat protein 17 isoform X2

      Conserved Domains (3) summary
      cd09293
      Location:363 → 456
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:362 → 387
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:321 → 366
      F-box-like

    RNA

    1. XR_385343.5 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_177143.2: Suppressed sequence

      Description
      NM_177143.2: This RefSeq was permanently suppressed because it contains the wrong CDS.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QZN1.3 GenPept UniProtKB/Swiss-Prot:Q9QZN1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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