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    POLY polyprotein [ Dengue virus type 4 ]

    Gene ID: 5075729, updated on 18-Nov-2023

    Summary

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    Gene symbol
    POLY
    Gene description
    polyprotein
    Locus tag
    DV4_gp1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Dengue virus type 4
    Lineage
    Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Flasuviricetes; Amarillovirales; Flaviviridae; Flavivirus; Dengue virus
    Also known as
    polyprotein gene
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    Genomic context

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    Location:
    clone: rDEN4
    Sequence:
    NC_002640.1 (102..10265)

    NC_002640.1Genomic Context describing neighboring genes

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002640.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Impact of bound ssRNA length on allostery in the Dengue Virus NS3 helicase. Amrein F, et al. Nucleic Acids Res, 2023 Nov 10. PMID 37823592, Free PMC Article
    2. NS3 helicase from dengue virus specifically recognizes viral RNA sequence to ensure optimal replication. Swarbrick CMD, et al. Nucleic Acids Res, 2017 Dec 15. PMID 29165589, Free PMC Article
    3. Secondary structure and membrane topology of dengue virus NS4A protein in micelles. Li Y, et al. Biochim Biophys Acta Biomembr, 2018 Feb. PMID 29055659
    4. The dengue virus non-structural protein 1 (NS1) is secreted from infected mosquito cells via a non-classical caveolin-1-dependent pathway. Alcalá AC, et al. J Gen Virol, 2017 Aug. PMID 28758625
    5. The helical domains of the stem region of dengue virus envelope protein are involved in both virus assembly and entry. Lin SR, et al. J Virol, 2011 May. PMID 21367896, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Impact of bound ssRNA length on allostery in the Dengue Virus NS3 helicase.
      Title: Impact of bound ssRNA length on allostery in the Dengue Virus NS3 helicase.
    2. Data indicate that NS4A contains six helices in dodecylphosphocholine (DPC) micelles, and the N-terminal three helices are amphipathic and interact with the membrane.
      Title: Secondary structure and membrane topology of dengue virus NS4A protein in micelles.
    3. Data indicate that the conformational flexibility around residue R538 of NS3 helicase is necessary for RNA translocation.
      Title: NS3 helicase from dengue virus specifically recognizes viral RNA sequence to ensure optimal replication.
    4. NS1 is released from mosquito cells via an unconventional secretory route that bypasses the Golgi complex, with the participation of CAV1.
      Title: The dengue virus non-structural protein 1 (NS1) is secreted from infected mosquito cells via a non-classical caveolin-1-dependent pathway.
    5. Data indicate that envelope (E) protein-specific IgM and IgG produced by antibody-secreting cells (ASC) were highly cross-reactive among the four virus serotypes.
      Title: Total and Envelope Protein-Specific Antibody-Secreting Cell Response in Pediatric Dengue Is Highly Modulated by Age and Subsequent Infections.
    6. The present study deals with the molecular modeling of the viral protein (NS3 of DENV1-4), the host protein (NRBP) and their interactions through protein-protein docking study.
      Title: Insight into structural organization and protein-protein interaction of non structural 3 (NS3) proteins from dengue serotypes.
    7. Collectively, these findings suggest that the EH1 and EH2 domains of E are involved in both assembly and entry steps of the dengue virus replication cycle
      Title: The helical domains of the stem region of dengue virus envelope protein are involved in both virus assembly and entry.
    8. We report that dengue virus (DENV) methyltransferase sequentially methylates the guanine N-7 and ribose 2'-O positions of viral RNA cap (GpppA-->m(7)GpppA-->m(7)GpppAm). [Methyltransferase]
      Title: Biochemical and genetic characterization of dengue virus methyltransferase.
    9. Flexibility between the protease and helicase domains of the dengue virus NS3 protein is conferred by the linker region
      Title: Flexibility between the protease and helicase domains of the dengue virus NS3 protein conferred by the linker region and its functional implications.
    10. RNA recognition by NS3 appears largely sequence independent in a way remarkably similar to eukaryotic DEAD box proteins Vasa and eIF4AIII.
      Title: Insights into RNA unwinding and ATP hydrolysis by the flavivirus NS3 protein.
    Submit: New GeneRIF Correction

    General gene information

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    regulatory

    • Loc: 136-146 regulatory_class = other

    stem_loop

    • Loc: 118-134

    General protein information

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    Preferred Names
    polyprotein
    Names
    capsid protein C
    anchored capsid protein ancC
    membrane glycoprotein precursor prM
    membrane glycoprotein M
    envelope protein E
    nonstructural protein NS1
    nonstructural protein NS2A
    nonstructural protein NS2B
    nonstructural protein NS3
    nonstructural protein NS4A
    protein 2K
    nonstructural protein NS4B
    RNA-dependent RNA polymerase NS5
    protein pr

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002640.1 Reference assembly

      Range
      102..10265
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_073286.1 polyprotein [Dengue virus type 4]

      See identical proteins and their annotated locations for NP_073286.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P09866, Q88661, Q88662, Q88663, Q88664, Q88665, Q88666, Q88667, Q88668, Q88669, Q88670, Q88671, Q99BK4, Q9DKQ5, Q9DKQ6, Q9DKQ7
      Conserved Domains (17) summary
      cd12149
      Location:584 → 673
      Flavi_E_C; Immunoglobulin-like domain III (C-terminal domain) of Flavivirus envelope glycoprotein E
      TIGR04240
      Location:678 → 774
      flavi_E_stem; flavivirus envelope glycoprotein E, stem/anchor domain
      smart00487
      Location:1656 → 1799
      DEXDc; DEAD-like helicases superfamily
      pfam01003
      Location:4 → 113
      Flavi_capsid; Flavivirus capsid protein C
      pfam00869
      Location:281 → 575
      Flavi_glycoprot; Flavivirus glycoprotein, central and dimerization domains
      pfam00948
      Location:777 → 1129
      Flavi_NS1; Flavivirus non-structural Protein NS1
      pfam00949
      Location:1493 → 1641
      Peptidase_S7; Peptidase S7, Flavivirus NS3 serine protease
      pfam00972
      Location:2738 → 3382
      Flavi_NS5; Flavivirus RNA-directed RNA polymerase
      pfam01002
      Location:1348 → 1474
      Flavi_NS2B; Flavivirus non-structural protein NS2B
      pfam01004
      Location:206 → 278
      Flavi_M; Flavivirus envelope glycoprotein M
      pfam01005
      Location:1137 → 1306
      Flavi_NS2A; Flavivirus non-structural protein NS2A
      pfam01349
      Location:2243 → 2480
      Flavi_NS4B; Flavivirus non-structural protein NS4B
      pfam01350
      Location:2097 → 2240
      Flavi_NS4A; Flavivirus non-structural protein NS4A
      pfam01570
      Location:119 → 203
      Flavi_propep; Flavivirus polyprotein propeptide
      pfam01728
      Location:2542 → 2709
      FtsJ; FtsJ-like methyltransferase
      pfam07652
      Location:1659 → 1804
      Flavi_DEAD; Flavivirus DEAD domain
      cl21455
      Location:1829 → 1938
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NP_740313.1 capsid protein C

      Conserved Domains (1) summary
      pfam01003
      Location:4 → 99
      Flavi_capsid; Flavivirus capsid protein C

    3. NP_740314.1 anchored capsid protein ancC

      Conserved Domains (1) summary
      pfam01003
      Location:4 → 113
      Flavi_capsid; Flavivirus capsid protein C

    4. NP_740315.1 membrane glycoprotein precursor prM

      UniProtKB/TrEMBL
      A4GV97
      Conserved Domains (2) summary
      pfam01004
      Location:93 → 165
      Flavi_M; Flavivirus envelope glycoprotein M
      pfam01570
      Location:6 → 90
      Flavi_propep; Flavivirus polyprotein propeptide

    5. NP_740316.1 membrane glycoprotein M

      Conserved Domains (1) summary
      pfam01004
      Location:2 → 74
      Flavi_M; Flavivirus envelope glycoprotein M

    6. NP_740317.1 envelope protein E

      UniProtKB/TrEMBL
      D0TZ11, D0TZ12, Q0QJV3, Q0QJV4, Q0QJV5, Q0QJV6, Q66439
      Conserved Domains (3) summary
      cd12149
      Location:305 → 394
      Flavi_E_C; Immunoglobulin-like domain III (C-terminal domain) of Flavivirus envelope glycoprotein E
      TIGR04240
      Location:399 → 495
      flavi_E_stem; flavivirus envelope glycoprotein E, stem/anchor domain
      pfam00869
      Location:2 → 296
      Flavi_glycoprot; Flavivirus glycoprotein, central and dimerization domains

    7. NP_740318.1 nonstructural protein NS1

      UniProtKB/TrEMBL
      A0A2H4ZCQ3, W8FN28, W8FRI1
      Conserved Domains (1) summary
      pfam00948
      Location:3 → 352
      Flavi_NS1; Flavivirus non-structural Protein NS1

    8. NP_740319.1 nonstructural protein NS2A

      Conserved Domains (1) summary
      pfam01005
      Location:11 → 180
      Flavi_NS2A; Flavivirus non-structural protein NS2A

    9. NP_740320.1 nonstructural protein NS2B

      UniProtKB/TrEMBL
      A0A1L2BPD5
      Conserved Domains (1) summary
      pfam01002
      Location:4 → 130
      Flavi_NS2B; Flavivirus non-structural protein NS2B

    10. NP_740321.1 nonstructural protein NS3

      Conserved Domains (4) summary
      smart00487
      Location:182 → 325
      DEXDc; DEAD-like helicases superfamily
      pfam00949
      Location:19 → 167
      Peptidase_S7; Peptidase S7, Flavivirus NS3 serine protease
      pfam07652
      Location:185 → 330
      Flavi_DEAD; Flavivirus DEAD domain
      cl21455
      Location:355 → 464
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    11. NP_740322.1 nonstructural protein NS4A

      Conserved Domains (1) summary
      pfam01350
      Location:5 → 127
      Flavi_NS4A; Flavivirus non-structural protein NS4A

    12. NP_740323.1 protein 2K

    13. NP_740324.1 nonstructural protein NS4B

      Conserved Domains (1) summary
      pfam01349
      Location:1 → 238
      Flavi_NS4B; Flavivirus non-structural protein NS4B

    14. NP_740325.1 RNA-dependent RNA polymerase NS5

      Conserved Domains (2) summary
      pfam00972
      Location:251 → 895
      Flavi_NS5; Flavivirus RNA-directed RNA polymerase
      pfam01728
      Location:55 → 222
      FtsJ; FtsJ-like methyltransferase

    15. YP_009164957.1 protein pr

      Conserved Domains (1) summary
      pfam01570
      Location:6 → 90
      Flavi_propep; Flavivirus polyprotein propeptide
    Nucleotide Protein
    Heading Accession and Version

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