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    TBCE tubulin folding cofactor E [ Bos taurus (cattle) ]

    Gene ID: 505066, updated on 6-Jun-2024

    Summary

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    Official Symbol
    TBCEprovided by VGNC
    Official Full Name
    tubulin folding cofactor Eprovided by VGNC
    Primary source
    VGNC:VGNC:35653
    See related
    BGD:BT27598; Ensembl:ENSBTAG00000013735
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See TBCE in Genome Data Viewer
    Location:
    chromosome: 28
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 28 NC_037355.1 (8099447..8188439)

    Chromosome 28 - NC_037355.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132344122 Neighboring gene AT-rich interaction domain 4B Neighboring gene geranylgeranyl diphosphate synthase 1 Neighboring gene beta-1,3-N-acetylgalactosaminyltransferase 2 Neighboring gene transfer RNA glycine (anticodon CCC) Neighboring gene transfer RNA tryptophan (anticodon CCA)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037355.1 Chromosome 28 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The alpha- and beta-tubulin folding pathways. Lewis SA, et al. Trends Cell Biol, 1997 Dec. PMID 17709011
    2. Tubulin subunits exist in an activated conformational state generated and maintained by protein cofactors. Tian G, et al. J Cell Biol, 1997 Aug 25. PMID 9265649, Free PMC Article
    3. Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Smith TP, et al. Genome Res, 2001 Apr. PMID 11282978, Free PMC Article
    4. Characterization of 954 bovine full-CDS cDNA sequences. Harhay GP, et al. BMC Genomics, 2005 Nov 23. PMID 16305752, Free PMC Article
    5. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC133938

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables alpha-tubulin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tubulin-specific chaperone E
    Names
    beta-tubulin cofactor E

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001038032.2 → NP_001033121.1  tubulin-specific chaperone E

      See identical proteins and their annotated locations for NP_001033121.1

      Status: PROVISIONAL

      Source sequence(s)
      BC109955
      UniProtKB/Swiss-Prot
      Q0V8R2, Q32KS0
      UniProtKB/TrEMBL
      A0A3Q1LP21
      Related
      ENSBTAP00000061803.2, ENSBTAT00000078439.2
      Conserved Domains (7) summary
      cd01769
      Location:457 → 526
      UBL; Ubiquitin-like domain of UBL
      smart01052
      Location:10 → 75
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd00116
      Location:124 → 212
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      pfam14580
      Location:234 → 396
      LRR_9; Leucine-rich repeat
      sd00033
      Location:129 → 154
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:153 → 192
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:153 → 242
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037355.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      8099447..8188439
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005226206.5 → XP_005226263.1  tubulin-specific chaperone E isoform X1

      See identical proteins and their annotated locations for XP_005226263.1

      UniProtKB/Swiss-Prot
      Q0V8R2, Q32KS0
      UniProtKB/TrEMBL
      A0A3Q1LP21
      Related
      ENSBTAP00000018249.4, ENSBTAT00000018249.5
      Conserved Domains (7) summary
      cd01769
      Location:457 → 526
      UBL; Ubiquitin-like domain of UBL
      smart01052
      Location:10 → 75
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd00116
      Location:124 → 212
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      pfam14580
      Location:234 → 396
      LRR_9; Leucine-rich repeat
      sd00033
      Location:129 → 154
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:153 → 192
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:153 → 242
      LRR_8; Leucine rich repeat

    2. XM_015460927.3 → XP_015316413.1  tubulin-specific chaperone E isoform X1

      UniProtKB/Swiss-Prot
      Q0V8R2, Q32KS0
      UniProtKB/TrEMBL
      A0A3Q1LP21
      Conserved Domains (7) summary
      cd01769
      Location:457 → 526
      UBL; Ubiquitin-like domain of UBL
      smart01052
      Location:10 → 75
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd00116
      Location:124 → 212
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      pfam14580
      Location:234 → 396
      LRR_9; Leucine-rich repeat
      sd00033
      Location:129 → 154
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:153 → 192
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:153 → 242
      LRR_8; Leucine rich repeat

    3. XM_010820420.3 → XP_010818722.1  tubulin-specific chaperone E isoform X2

      See identical proteins and their annotated locations for XP_010818722.1

      Conserved Domains (5) summary
      cd01769
      Location:339 → 408
      UBL; Ubiquitin-like domain of UBL
      COG4886
      Location:35 → 335
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      cd00116
      Location:6 → 94
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:11 → 36
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:35 → 74
      LRR_4; Leucine Rich repeats (2 copies)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q32KS0.1 GenPept UniProtKB/Swiss-Prot:Q32KS0

    Gene LinkOut

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