OVGP1 oviductal glycoprotein 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: OVGP1provided by HGNC
Official Full Name: oviductal glycoprotein 1provided by HGNC
Primary source: HGNC:HGNC:8524
See related: Ensembl:ENSG00000085465 MIM:603578; AllianceGenome:HGNC:8524
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: EGP; OGP; MUC9; CHIT5
Summary: This gene encodes a large, carbohydrate-rich, epithelial glycoprotein with numerous O-glycosylation sites located within threonine, serine, and proline-rich tandem repeats. The gene is similar to members of the mucin and the glycosyl hydrolase 18 gene families. Regulation of expression may be estrogen-dependent. Gene expression and protein secretion occur during late follicular development through early cleavage-stage embryonic development. The protein is secreted from non-ciliated oviductal epithelial cells and associates with ovulated oocytes, blastomeres, and spermatozoan acrosomal regions. [provided by RefSeq, Jul 2008]
Expression: Broad expression in endometrium (RPKM 11.4), testis (RPKM 3.0) and 16 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1p13.2

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (111414319..111427735, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (111429011..111442427, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (111956941..111970357, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The present study revealed that one of the major rHuOVGP1-enhanced pY proteins could be AKAP3 of the FS and that rHuOVGP1 is capable of binding to human ZP and its presence in the medium results in an increase in sperm-zona binding. Supplement of rHuOVGP1 in in vitro fertilization media could be beneficial for enhancement of the fertilizing ability of human sperm.
Title: Human OVGP1 enhances tyrosine phosphorylation of proteins in the fibrous sheath involving AKAP3 and increases sperm-zona binding.
OVGP1 is specifically induced in the luminal epithelium at the time of embryo implantation where it regulates receptivity-related genes and aids in trophoblast adhesion.
Title: Oviductal glycoprotein 1 (OVGP1) is expressed by endometrial epithelium that regulates receptivity and trophoblast adhesion.
Decreased gene expression of MUC9 was found from colonic biopsies in patients with active and remission ulcerative colitis.
Title: Reduced expression of mucin 9 (MUC9) in patients with ulcerative colitis.
Observational study of gene-disease association. (HuGE Navigator)
Title: Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.
OVGP1 seems to detect a different spectrum of ovarian epithelial cancers than other markers and thus should be a useful adjunct for more accurate detection, particularly of early serous ovarian cancers and mucinous carcinomas.
Title: Oviductal glycoprotein (OVGP1, MUC9): a differentiation-based mucin present in serum of women with ovarian cancer.
Reflux laryngitis is associated with down-regulation of mucin gene expression.
Title: Mucin gene expression in human laryngeal epithelia: effect of laryngopharyngeal reflux.
Gain of oviduct-specific glycoprotein is associated with the development of endometrial hyperplasia and endometrial cancer
Title: Gain of OGP, an estrogen-regulated oviduct-specific glycoprotein, is associated with the development of endometrial hyperplasia and endometrial cancer.
The presence of oviductin mRNA and protein has been determined in OE-E6/E7, an immortalized human oviductal epithelial cell line.
Title: Expression of human oviductin in an immortalized human oviductal cell line.
The production and function of oviductin at different stages of human reproductive cycle is not well known. Its highest expression at the time of ovulation is consistent with a supportive role in fertilization and early embryo development.
Title: Variable expression of oviductin mRNA at different stages of human reproductive cycle.
Results suggests the binding of OGP to human sperm mediates through MYH9.
Title: Identification and characterization of oviductal glycoprotein-binding protein partner on gametes: epitopic similarity to non-muscle myosin IIA, MYH 9.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

OVGP1_1686 (e-PCR)
- UniSTS:277548

D1S3210 (e-PCR)
- UniSTS:3675

RH70550 (e-PCR)
- UniSTS:73900

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables chitin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chitinase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in chitin catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in female pregnancy	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of binding of sperm to zona pellucida	IEA Inferred from Electronic Annotation more info
involved_in single fertilization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	TAS Traceable Author Statement more info
located_in egg coat	IEA Inferred from Electronic Annotation more info
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info
located_in microtubule cytoskeleton	IDA Inferred from Direct Assay more info
located_in perivitelline space	IEA Inferred from Electronic Annotation more info
located_in transport vesicle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: oviduct-specific glycoprotein

Names: estrogen-dependent oviduct protein; mucin 9; oviduct glycoprotein; oviductal glycoprotein 1, 120kDa; oviductin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_052675.1 RefSeqGene

Range

5043..18459

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_002557.4 → NP_002548.3 oviduct-specific glycoprotein precursor

See identical proteins and their annotated locations for NP_002548.3

Status: REVIEWED

Source sequence(s)

AY189737, U09550

Consensus CDS

CCDS834.1

UniProtKB/Swiss-Prot

A0AV19, B9EGE1, Q12889, Q15841

UniProtKB/TrEMBL

Q86YN0

Related

ENSP00000358747.3, ENST00000369732.4

Conserved Domains (2) summary

cd02872
Location:24 → 382

GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...

COG3889
Location:368 → 557

COG3889; Predicted periplasmic protein [Function unknown]