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    Lrrn1 leucine rich repeat neuronal 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500280, updated on 2-Nov-2024

    Summary

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    Symbol
    Lrrn1provided by RGD
    Full Name
    leucine rich repeat neuronal 1provided by RGD
    Primary source
    RGD:1564145
    See related
    EnsemblRapid:ENSRNOG00000006802 AllianceGenome:RGD:1564145
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to act upstream of or within positive regulation of synapse assembly. Predicted to be located in membrane. Predicted to be active in extracellular matrix and extracellular space. Orthologous to human LRRN1 (leucine rich repeat neuronal 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 71.0), Lung (RPKM 16.4) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lrrn1 in Genome Data Viewer
    Location:
    4q41
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (142032805..142072320)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (140476752..140520210)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (139633310..139679730)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene ALG11, alpha-1,2-mannosyltransferase, pseudogene 1 Neighboring gene ribosomal protein S7, pseudogene 6 Neighboring gene uncharacterized LOC134486828 Neighboring gene uncharacterized LOC134486829

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of a prognostic 5-Gene expression signature for gastric cancer. Hou JY, et al. J Cancer Res Clin Oncol, 2017 Apr. PMID 28035468
    2. Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins. Um JW, et al. Cell Rep, 2014 Mar 27. PMID 24613359, Free PMC Article
    3. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC124972

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of synapse assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat neuronal protein 1
    Names
    NLRR-1
    neuronal leucine-rich repeat protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037363.1 → NP_001032440.1  leucine-rich repeat neuronal protein 1 precursor

      See identical proteins and their annotated locations for NP_001032440.1

      Status: PROVISIONAL

      Source sequence(s)
      BC107902
      UniProtKB/Swiss-Prot
      Q32Q07
      UniProtKB/TrEMBL
      A6IBK4
      Conserved Domains (7) summary
      smart00060
      Location:531 → 600
      FN3; Fibronectin type 3 domain
      smart00082
      Location:371 → 419
      LRRCT; Leucine rich repeat C-terminal domain
      COG4886
      Location:68 → 372
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:339 → 362
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:97 → 120
      LRR_RI; leucine-rich repeat [structural motif]
      pfam07679
      Location:429 → 516
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:433 → 438
      Ig; Ig strand A' [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      142032805..142072320
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006236984.5 → XP_006237046.1  leucine-rich repeat neuronal protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006237046.1

      UniProtKB/Swiss-Prot
      Q32Q07
      UniProtKB/TrEMBL
      A6IBK4
      Related
      ENSRNOP00000008879.4, ENSRNOT00000008879.7
      Conserved Domains (7) summary
      smart00060
      Location:531 → 600
      FN3; Fibronectin type 3 domain
      smart00082
      Location:371 → 419
      LRRCT; Leucine rich repeat C-terminal domain
      COG4886
      Location:68 → 372
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:339 → 362
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:97 → 120
      LRR_RI; leucine-rich repeat [structural motif]
      pfam07679
      Location:429 → 516
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:433 → 438
      Ig; Ig strand A' [structural motif]

    2. XM_017592833.3 → XP_017448322.1  leucine-rich repeat neuronal protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q32Q07
      UniProtKB/TrEMBL
      A6IBK4
      Related
      ENSRNOP00000082837.1, ENSRNOT00000114168.2
      Conserved Domains (7) summary
      smart00060
      Location:531 → 600
      FN3; Fibronectin type 3 domain
      smart00082
      Location:371 → 419
      LRRCT; Leucine rich repeat C-terminal domain
      COG4886
      Location:68 → 372
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:339 → 362
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:97 → 120
      LRR_RI; leucine-rich repeat [structural motif]
      pfam07679
      Location:429 → 516
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:433 → 438
      Ig; Ig strand A' [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q32Q07.1 GenPept UniProtKB/Swiss-Prot:Q32Q07

    Gene LinkOut

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