Rfk riboflavin kinase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rfkprovided by RGD
Official Full Name: riboflavin kinaseprovided by RGD
Primary source: RGD:1549748
See related: AllianceGenome:RGD:1549748
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable riboflavin kinase activity. Predicted to be involved in FMN biosynthetic process; flavin adenine dinucleotide biosynthetic process; and riboflavin metabolic process. Predicted to act upstream of or within apoptotic process; positive regulation of NAD(P)H oxidase activity; and reactive oxygen species metabolic process. Predicted to be active in cytosol and mitochondrion. Orthologous to human RFK (riboflavin kinase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 859.7), Liver (RPKM 426.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q43

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (224226632..224234185)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (214799880..214807440)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (236494221..236501733, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

RH128027 (e-PCR)
- UniSTS:211336

RH129140 (e-PCR)
- UniSTS:212448

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables riboflavin kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables riboflavin kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in FMN biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in FMN biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in flavin adenine dinucleotide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of NAD(P)H oxidase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
involved_in riboflavin biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in riboflavin metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in riboflavin metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: riboflavin kinase

NP_001014128.1

EC 2.7.1.26

XP_038943862.1

EC 2.7.1.26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.