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    HHV8GK18_gp82 ORF72 [ Human gammaherpesvirus 8 ]

    Gene ID: 4961471, updated on 18-Aug-2023

    Summary

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    Gene symbol
    HHV8GK18_gp82
    Gene description
    ORF72
    Locus tag
    HHV8GK18_gp82
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Human gammaherpesvirus 8 (strain: GK18, type: P, common: Kaposi's sarcoma-associated herpesvirus, acronym: HHV-8, acronym: KSHV, nat-host: Homo sapiens)
    Lineage
    Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Gammaherpesvirinae; Rhadinovirus
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    Genomic context

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    Sequence:
    NC_009333.1 (123010..123815, complement)

    NC_009333.1Genomic Context describing neighboring genes Neighboring gene ORF71 Neighboring gene miscRNA Neighboring gene ORF73 Neighboring gene K14 Neighboring gene ORF74 Neighboring gene ORF75 Neighboring gene K15

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_009333.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. KSHV vCyclin counters the senescence/G1 arrest response triggered by NF-κB hyperactivation. Zhi H, et al. Oncogene, 2015 Jan 22. PMID 24469036, Free PMC Article
    2. Kaposi's sarcoma-associated herpesvirus K-cyclin interacts with Cdk9 and stimulates Cdk9-mediated phosphorylation of p53 tumor suppressor. Chang PC, et al. J Virol, 2008 Jan. PMID 17942552, Free PMC Article
    3. Kaposi's sarcoma-associated herpesvirus immune modulation: an overview. Rezaee SAR, et al. J Gen Virol, 2006 Jul. PMID 16760382
    4. Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes. Davis ZH, et al. Mol Cell, 2015 Jan 22. PMID 25544563, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. deregulation of the G1 cyclin-dependent kinase can facilitate chronic I-kappaB kinases/NF-kappaB activation
      Title: KSHV vCyclin counters the senescence/G1 arrest response triggered by NF-κB hyperactivation.
    2. K-cyclin/Cdk9 interaction greatly enhanced the kinase activity of Cdk9 toward p53.
      Title: Kaposi's sarcoma-associated herpesvirus K-cyclin interacts with Cdk9 and stimulates Cdk9-mediated phosphorylation of p53 tumor suppressor.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    regulatory

    • Loc: c123015-123010 regulatory_class = polyA_signal_sequence

    General protein information

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    Preferred Names
    ORF72
    Names
    vCyclin
    YP_001129430.1
    • contains two cyclin-like domains

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_009333.1 Reference assembly

      Range
      123010..123815 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_001129430.1 ORF72 [Human gammaherpesvirus 8]

      See identical proteins and their annotated locations for YP_001129430.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      D0UZU0, Q77Q36
      UniProtKB/TrEMBL
      A0A0N9SEN2, A0A7D3QG58, A0A7D5KAR4, E5LC00, F5HC81, O40946, P88962, Q98147
      Conserved Domains (2) summary
      pfam09080
      Location:148 → 251
      K-cyclin_vir_C; K cyclin, C terminal
      cl40454
      Location:46 → 144
      CYCLIN_SF; Cyclin box fold superfamily
    Nucleotide Protein
    Heading Accession and Version

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