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    HHV8GK18_gp84 ORF74 [ Human gammaherpesvirus 8 ]

    Gene ID: 4961460, updated on 18-Aug-2023

    Summary

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    Gene symbol
    HHV8GK18_gp84
    Gene description
    ORF74
    Locus tag
    HHV8GK18_gp84
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Human gammaherpesvirus 8 (strain: GK18, type: P, common: Kaposi's sarcoma-associated herpesvirus, acronym: HHV-8, acronym: KSHV, nat-host: Homo sapiens)
    Lineage
    Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Gammaherpesvirinae; Rhadinovirus
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    Genomic context

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    Sequence:
    NC_009333.1 (129520..130671)

    NC_009333.1Genomic Context describing neighboring genes Neighboring gene ORF71 Neighboring gene ORF72 Neighboring gene ORF73 Neighboring gene K14 Neighboring gene ORF75 Neighboring gene K15

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_009333.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The viral G protein-coupled receptor ORF74 unmasks phospholipase C signaling of the receptor tyrosine kinase IGF-1R. de Munnik SM, et al. Cell Signal, 2016 Jun. PMID 26931381
    2. The Viral G Protein-Coupled Receptor ORF74 Hijacks β-Arrestins for Endocytic Trafficking in Response to Human Chemokines. de Munnik SM, et al. PLoS One, 2015. PMID 25894435, Free PMC Article
    3. Glycosylation of KSHV encoded vGPCR functions in its signaling and tumorigenicity. Wu H, et al. Viruses, 2015 Mar 31. PMID 25835533, Free PMC Article
    4. YGLF motif in the Kaposi sarcoma herpes virus G-protein-coupled receptor adjusts NF-κB activation and paracrine actions. Azzi S, et al. Oncogene, 2014 Dec 4. PMID 24292677
    5. Endolysosomal trafficking of viral G protein-coupled receptor functions in innate immunity and control of viral oncogenesis. Dong X, et al. Proc Natl Acad Sci U S A, 2016 Mar 15. PMID 26929373, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Unmasking IGF-1R signaling to PLC in response to IGF-1 is a previously unrecognized action of ORF74.
      Title: The viral G protein-coupled receptor ORF74 unmasks phospholipase C signaling of the receptor tyrosine kinase IGF-1R.
    2. Beclin 2, interacts with KSHV GPCR, encoded by ORF74, facilitates its endolysosomal degradation, and inhibits vGPCR-driven oncogenic signaling.
      Title: Endolysosomal trafficking of viral G protein-coupled receptor functions in innate immunity and control of viral oncogenesis.
    3. ORF74 recruits beta-arrestins and subsequently internalizes in response to human chemokines
      Title: The Viral G Protein-Coupled Receptor ORF74 Hijacks β-Arrestins for Endocytic Trafficking in Response to Human Chemokines.
    4. These findings support the conclusion that glycosylation is critical for viral G protein-coupled receptor (vGPCR) tumorigenesis and imply that chemokine regulation at the plasma membrane is crucial for vGPCR mediated signaling.
      Title: Glycosylation of KSHV encoded vGPCR functions in its signaling and tumorigenicity.
    5. the YGLF motif in the Kaposi sarcoma herpes virus G-protein-coupled receptor adjusts NF-kappaB activation and paracrine actions
      Title: YGLF motif in the Kaposi sarcoma herpes virus G-protein-coupled receptor adjusts NF-κB activation and paracrine actions.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    regulatory

    • Loc: 130666-130671 regulatory_class = polyA_signal_sequence

    General protein information

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    Preferred Names
    ORF74
    Names
    vGPCR
    YP_001129433.1
    • similar to IL-8 receptor; transforming protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_009333.1 Reference assembly

      Range
      129520..130671
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_001129433.1 ORF74 [Human gammaherpesvirus 8]

      See identical proteins and their annotated locations for YP_001129433.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O12573, P88966, Q77Q35, Q98146
      UniProtKB/TrEMBL
      A0A7D5UH77, O90387, Q76SF8, Q9QEV2
      Conserved Domains (2) summary
      cd14964
      Location:53 → 75
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:53 → 325
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    Nucleotide Protein
    Heading Accession and Version

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