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    dusp6.S dual specificity phosphatase 6 S homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 495060, updated on 4-Nov-2024

    Summary

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    Official Symbol
    dusp6.S
    Official Full Name
    dual specificity phosphatase 6 S homeolog
    Primary source
    Xenbase:XB-GENE-17333168
    Locus tag
    XELAEV_18021247mg
    See related
    EnsemblRapid:ENSXLAG00005021163 AllianceGenome:Xenbase:XB-GENE-17333168
    Gene type
    protein coding
    RefSeq status
    PREDICTED
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    X17C; mkp3; pyst1
    Summary
    Predicted to enable phosphoprotein phosphatase activity. Predicted to act upstream of or within several processes, including negative regulation of ERK1 and ERK2 cascade; protein dephosphorylation; and regulation of heart growth. Predicted to be located in cytosol. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 19 with or without anosmia. Orthologous to human DUSP6 (dual specificity phosphatase 6). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See dusp6.S in Genome Data Viewer
    Location:
    chromosome: 3S
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 3S NC_054376.1 (92643743..92649716)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 3S NC_030729.1 (90816807..90822780)

    Chromosome 3S - NC_054376.1Genomic Context describing neighboring genes Neighboring gene epiphycan S homeolog Neighboring gene ATPase, Ca++ transporting, plasma membrane 1 S homeolog Neighboring gene solute carrier family 23 member 1-like Neighboring gene KIT ligand S homeolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables MAP kinase tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase tyrosine/serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of heart growth IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein LOC495060
    Names
    MAP kinase phosphatase

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001094761.2 → NP_001088230.1  uncharacterized protein LOC495060

      See identical proteins and their annotated locations for NP_001088230.1

      Status: PREDICTED

      Source sequence(s)
      BC084215
      UniProtKB/TrEMBL
      A0A974DAQ8, Q5XH58
      Related
      ENSXLAP00005062090.1, ENSXLAT00005063543.1
      Conserved Domains (3) summary
      COG2453
      Location:202 → 354
      CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
      cd00127
      Location:205 → 342
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
      cd01446
      Location:20 → 147
      DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054376.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      92643743..92649716
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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