FAS Fas cell surface death receptor [Felis catus (domestic cat)] - Gene

Summary

Gene symbol: FAS
Gene description: Fas cell surface death receptor
See related: EnsemblRapid:ENSFCTG00005004474
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Felis catus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis
Also known as: TNFRSF6
Orthologs: human mouse all
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Genomic context

Location:: chromosome: D2

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
105	current	F.catus_Fca126_mat1.0 (GCF_018350175.1)	D2	NC_058378.1 (8460783..8487080)
104	previous assembly	Felis_catus_9.0 (GCF_000181335.3)	D2	NC_018733.3 (8634382..8660988)

Chromosome D2 - NC_058378.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The whole genomes of two affected kittens were sequenced and compared to 82 existing cat genomes. Both BSH kittens had homozygous insertions of an adenine within exon 3 of the FAS-ligand gene. The resultant frameshift and premature stop codon were predicted to result in a severely truncated protein that is unlikely to be able to activate FAS
Title: A FAS-ligand variant associated with autoimmune lymphoproliferative syndrome in cats.
alternatively spliced Fas variants may be associated with the pathogenesis of feline lymphoma.
Title: Alternatively spliced transcripts of Fas mRNAs in feline lymphoid cells.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed
enables tumor necrosis factor receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in activation-induced cell death of T cells	IEA Inferred from Electronic Annotation more info	PubMed
involved_in extrinsic apoptotic signaling pathway in absence of ligand	IEA Inferred from Electronic Annotation more info	PubMed
involved_in immune response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in motor neuron apoptotic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in necroptotic signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of stress-activated MAPK cascade	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of CD95 death-inducing signaling complex	IEA Inferred from Electronic Annotation more info	PubMed
located_in external side of plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in membrane raft	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: tumor necrosis factor receptor superfamily member 6

Names: Fas (TNF receptor superfamily, member 6); Fas antigen; tumor necrosis factor receptor superfamily, member 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001009314.1 → NP_001009314.1 tumor necrosis factor receptor superfamily member 6 precursor

See identical proteins and their annotated locations for NP_001009314.1

Status: PROVISIONAL

Source sequence(s)

AB009279

UniProtKB/TrEMBL

A0A2I2U2C0, Q861W6

Related

ENSFCTP00005007772.1, ENSFCTT00005012117.1

Conserved Domains (2) summary

cd08316
Location:220 → 312

Death_FAS_TNFRSF6; Death domain of FAS or TNF receptor superfamily member 6

cd10579
Location:39 → 167

TNFRSF6; Tumor necrosis factor receptor superfamily member 6 (TNFRSF6), also known as fas cell surface death receptor (Fas)