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    BCHE butyrylcholinesterase [ Canis lupus familiaris (dog) ]

    Gene ID: 488143, updated on 17-Aug-2024

    Summary

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    Official Symbol
    BCHEprovided by VGNC
    Official Full Name
    butyrylcholinesteraseprovided by VGNC
    Primary source
    VGNC:VGNC:38405
    See related
    Ensembl:ENSCAFG00845018401
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See BCHE in Genome Data Viewer
    Location:
    chromosome: 34
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 34 NC_051838.1 (30973335..31038334, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 34 NC_006616.4 (39973463..40038402, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 34 NC_049255.1 (31141049..31206522, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 34 NC_049294.1 (30917722..30976598, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 34 NC_049775.1 (30878067..30943017, complement)

    Chromosome 34 - NC_051838.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119867517 Neighboring gene uncharacterized LOC119867518 Neighboring gene uncharacterized LOC111093825 Neighboring gene uncharacterized LOC119867519 Neighboring gene uncharacterized LOC102156697 Neighboring gene small VCP/p97-interacting protein-like Neighboring gene uncharacterized LOC111093895

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Butyrylcholinesterase as a marker of inflammation and liver injury in the acute and subclinical phases of canine ehrlichiosis. do Carmo GM, et al. Comp Immunol Microbiol Infect Dis, 2015 Dec. PMID 26616656
    2. Serum butyrylcholinesterase activity in dogs with diabetes mellitus. Tvarijonaviciute A, et al. Vet J, 2012 Jun. PMID 21820337
    3. The diagnostic and prognostic value of paraoxonase-1 and butyrylcholinesterase activities compared with acute-phase proteins in septic dogs and stratified by the acute patient physiologic and laboratory evaluation score. Torrente C, et al. Vet Clin Pathol, 2019 Dec. PMID 31789474
    4. Use of the polymerase chain reaction for homology probing of butyrylcholinesterase from several vertebrates. Arpagaus M, et al. J Biol Chem, 1991 Apr 15. PMID 2016308

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the diagnostic and prognostic value of PON-1 and BChE in septic dogs
      Title: The diagnostic and prognostic value of paraoxonase-1 and butyrylcholinesterase activities compared with acute-phase proteins in septic dogs and stratified by the acute patient physiologic and laboratory evaluation score.
    2. Acute infection caused by Ehrlichia canis in dogs leads to an increase on seric BChE activity and some inflammatory mediators.
      Title: Butyrylcholinesterase as a marker of inflammation and liver injury in the acute and subclinical phases of canine ehrlichiosis.
    3. A statistically significant increase in BChE activity was found in the diabetic dogs compared with the clinically normal animals, and with the dogs with other diseases.
      Title: Serum butyrylcholinesterase activity in dogs with diabetes mellitus.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables acetylcholinesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in acetylcholine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in choline metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cholinesterase
    Names
    acylcholine acylhydrolase
    butylcholinesterase
    butyrylcholine esterase
    choline esterase II
    pseudocholinesterase
    NP_001300790.1
    XP_038301325.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313861.2 → NP_001300790.1  cholinesterase precursor

      Status: PROVISIONAL

      Source sequence(s)
      JAAUVH010000363
      UniProtKB/TrEMBL
      A0A8C0L952, A0A8C0NAH8, A0A8I3PBA0
      Related
      ENSCAFP00845025442.1, ENSCAFT00845032535.1
      Conserved Domains (3) summary
      COG0657
      Location:128 → 250
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam00135
      Location:26 → 550
      COesterase; Carboxylesterase family
      pfam08674
      Location:565 → 599
      AChE_tetra; Acetylcholinesterase tetramerization domain

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051838.1 Reference ROS_Cfam_1.0

      Range
      30973335..31038334 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038445397.1 → XP_038301325.1  cholinesterase isoform X1

      UniProtKB/TrEMBL
      A0A8C0L952
      Conserved Domains (1) summary
      pfam00135
      Location:30 → 509
      COesterase; Carboxylesterase family

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049294.1 Alternate UMICH_Zoey_3.1

      Range
      30917722..30976598 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049775.1 Alternate UNSW_CanFamBas_1.0

      Range
      30878067..30943017 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049255.1 Alternate UU_Cfam_GSD_1.0

      Range
      31141049..31206522 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006616.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      39973463..40038402 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32750.1 GenPept UniProtKB/Swiss-Prot:P32750

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.