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    CYP39A1 cytochrome P450 family 39 subfamily A member 1 [ Canis lupus familiaris (dog) ]

    Gene ID: 481825, updated on 17-Aug-2024

    Summary

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    Official Symbol
    CYP39A1provided by VGNC
    Official Full Name
    cytochrome P450 family 39 subfamily A member 1provided by VGNC
    Primary source
    VGNC:VGNC:50359
    See related
    Ensembl:ENSCAFG00845012904
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See CYP39A1 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 12 NC_051816.1 (15228042..15318048, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 12 NC_006594.4 (14759739..14849550, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 12 NC_049233.1 (14929415..15019242, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 12 NC_049272.1 (14744051..14833700, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 12 NC_049753.1 (14832622..14922602, complement)

    Chromosome 12 - NC_051816.1Genomic Context describing neighboring genes Neighboring gene regulator of calcineurin 2 Neighboring gene uncharacterized LOC119874173 Neighboring gene heat shock cognate 71 kDa protein-like Neighboring gene U6 spliceosomal RNA Neighboring gene solute carrier family 25 member 27 Neighboring gene tudor domain containing 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables steroid hydroxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in bile acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cholesterol homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    24-hydroxycholesterol 7-alpha-hydroxylase
    Names
    cytochrome P450, family 39, subfamily A, polypeptide 1
    XP_005627475.1
    XP_005627476.1
    XP_013973965.1
    XP_013973966.1
    XP_022281830.1
    XP_038347909.1
    XP_038347910.1
    XP_038347911.1
    XP_038347912.1
    XP_038347913.1
    XP_038347914.1
    XP_038410170.1
    XP_038410171.1
    XP_038410172.1
    XP_038410173.1
    XP_038410174.1
    XP_038410175.1
    XP_038474038.1
    XP_038474039.1
    XP_038474040.1
    XP_038474041.1
    XP_038474042.1
    XP_038474044.1
    XP_038539626.1
    XP_038539627.1
    XP_038539628.1
    XP_038539629.1
    XP_038539630.1
    XP_038539631.1
    XP_538946.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051816.1 Reference ROS_Cfam_1.0

      Range
      15228042..15318048 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038683703.1 → XP_038539631.1  24-hydroxycholesterol 7-alpha-hydroxylase isoform X6

      Conserved Domains (1) summary
      cl41757
      Location:1 → 292
      cytochrome_P450; cytochrome P450 (CYP) superfamily

    2. XM_038683700.1 → XP_038539628.1  24-hydroxycholesterol 7-alpha-hydroxylase isoform X3

      UniProtKB/TrEMBL
      A0A8C0SF75
      Conserved Domains (1) summary
      cl41757
      Location:1 → 439
      cytochrome_P450; cytochrome P450 (CYP) superfamily

    3. XM_038683698.1 → XP_038539626.1  24-hydroxycholesterol 7-alpha-hydroxylase isoform X1

      UniProtKB/TrEMBL
      A0A8C0SF29, A0A8C0SF75, A0A8I3RX90
      Related
      ENSCAFP00845017996.1, ENSCAFT00845022957.1
      Conserved Domains (1) summary
      cd20635
      Location:49 → 507
      CYP39A1; cytochrome P450 family 39, subfamily A, polypeptide 1

    4. XM_038683699.1 → XP_038539627.1  24-hydroxycholesterol 7-alpha-hydroxylase isoform X2

      UniProtKB/TrEMBL
      A0A8C0MF94, A0A8C0R040, A0A8I3NQ76, A0A8P0S869
      Related
      ENSCAFP00845018033.1, ENSCAFT00845023004.1
      Conserved Domains (1) summary
      cd20635
      Location:49 → 462
      CYP39A1; cytochrome P450 family 39, subfamily A, polypeptide 1

    5. XM_038683702.1 → XP_038539630.1  24-hydroxycholesterol 7-alpha-hydroxylase isoform X5

      Conserved Domains (1) summary
      cl41757
      Location:1 → 341
      cytochrome_P450; cytochrome P450 (CYP) superfamily

    6. XM_038683701.1 → XP_038539629.1  24-hydroxycholesterol 7-alpha-hydroxylase isoform X4

      Conserved Domains (1) summary
      cl41757
      Location:1 → 386
      cytochrome_P450; cytochrome P450 (CYP) superfamily

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049272.1 Alternate UMICH_Zoey_3.1

      Range
      14744051..14833700 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038491986.1 → XP_038347914.1  24-hydroxycholesterol 7-alpha-hydroxylase isoform X6

      Conserved Domains (1) summary
      cl41757
      Location:1 → 292
      cytochrome_P450; cytochrome P450 (CYP) superfamily

    2. XM_038491983.1 → XP_038347911.1  24-hydroxycholesterol 7-alpha-hydroxylase isoform X3

      Conserved Domains (1) summary
      cl41757
      Location:1 → 439
      cytochrome_P450; cytochrome P450 (CYP) superfamily

    3. XM_038491981.1 → XP_038347909.1  24-hydroxycholesterol 7-alpha-hydroxylase isoform X1

      Conserved Domains (1) summary
      cd20635
      Location:49 → 507
      CYP39A1; cytochrome P450 family 39, subfamily A, polypeptide 1

    4. XM_038491982.1 → XP_038347910.1  24-hydroxycholesterol 7-alpha-hydroxylase isoform X2

      Conserved Domains (1) summary
      cd20635
      Location:49 → 462
      CYP39A1; cytochrome P450 family 39, subfamily A, polypeptide 1

    5. XM_038491985.1 → XP_038347913.1  24-hydroxycholesterol 7-alpha-hydroxylase isoform X5

      Conserved Domains (1) summary
      cl41757
      Location:1 → 341
      cytochrome_P450; cytochrome P450 (CYP) superfamily

    6. XM_038491984.1 → XP_038347912.1  24-hydroxycholesterol 7-alpha-hydroxylase isoform X4

      Conserved Domains (1) summary
      cl41757
      Location:1 → 386
      cytochrome_P450; cytochrome P450 (CYP) superfamily

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049753.1 Alternate UNSW_CanFamBas_1.0

      Range
      14832622..14922602 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038618116.1 → XP_038474044.1  24-hydroxycholesterol 7-alpha-hydroxylase isoform X6

      Conserved Domains (1) summary
      cl41757
      Location:1 → 292
      cytochrome_P450; cytochrome P450 (CYP) superfamily

    2. XM_038618112.1 → XP_038474040.1  24-hydroxycholesterol 7-alpha-hydroxylase isoform X3

      Conserved Domains (1) summary
      cl41757
      Location:1 → 439
      cytochrome_P450; cytochrome P450 (CYP) superfamily

    3. XM_038618110.1 → XP_038474038.1  24-hydroxycholesterol 7-alpha-hydroxylase isoform X1

      Conserved Domains (1) summary
      cd20635
      Location:49 → 507
      CYP39A1; cytochrome P450 family 39, subfamily A, polypeptide 1

    4. XM_038618111.1 → XP_038474039.1  24-hydroxycholesterol 7-alpha-hydroxylase isoform X2

      Conserved Domains (1) summary
      cd20635
      Location:49 → 462
      CYP39A1; cytochrome P450 family 39, subfamily A, polypeptide 1

    5. XM_038618114.1 → XP_038474042.1  24-hydroxycholesterol 7-alpha-hydroxylase isoform X5

      Conserved Domains (1) summary
      cl41757
      Location:1 → 341
      cytochrome_P450; cytochrome P450 (CYP) superfamily

    6. XM_038618113.1 → XP_038474041.1  24-hydroxycholesterol 7-alpha-hydroxylase isoform X4

      Conserved Domains (1) summary
      cl41757
      Location:1 → 386
      cytochrome_P450; cytochrome P450 (CYP) superfamily

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049233.1 Alternate UU_Cfam_GSD_1.0

      Range
      14929415..15019242 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038554247.1 → XP_038410175.1  24-hydroxycholesterol 7-alpha-hydroxylase isoform X6

      Conserved Domains (1) summary
      cl41757
      Location:1 → 292
      cytochrome_P450; cytochrome P450 (CYP) superfamily

    2. XM_038554244.1 → XP_038410172.1  24-hydroxycholesterol 7-alpha-hydroxylase isoform X3

      UniProtKB/TrEMBL
      A0A8C0SF75
      Conserved Domains (1) summary
      cl41757
      Location:1 → 439
      cytochrome_P450; cytochrome P450 (CYP) superfamily

    3. XM_038554242.1 → XP_038410170.1  24-hydroxycholesterol 7-alpha-hydroxylase isoform X1

      UniProtKB/TrEMBL
      A0A8C0SF29, A0A8C0SF75, A0A8I3RX90
      Conserved Domains (1) summary
      cd20635
      Location:49 → 507
      CYP39A1; cytochrome P450 family 39, subfamily A, polypeptide 1

    4. XM_038554243.1 → XP_038410171.1  24-hydroxycholesterol 7-alpha-hydroxylase isoform X2

      UniProtKB/TrEMBL
      A0A8C0MF94, A0A8C0R040, A0A8I3NQ76, A0A8P0S869
      Conserved Domains (1) summary
      cd20635
      Location:49 → 462
      CYP39A1; cytochrome P450 family 39, subfamily A, polypeptide 1

    5. XM_038554246.1 → XP_038410174.1  24-hydroxycholesterol 7-alpha-hydroxylase isoform X5

      Conserved Domains (1) summary
      cl41757
      Location:1 → 341
      cytochrome_P450; cytochrome P450 (CYP) superfamily

    6. XM_038554245.1 → XP_038410173.1  24-hydroxycholesterol 7-alpha-hydroxylase isoform X4

      Conserved Domains (1) summary
      cl41757
      Location:1 → 386
      cytochrome_P450; cytochrome P450 (CYP) superfamily

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006594.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      14759739..14849550 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_022426122.2 → XP_022281830.1  24-hydroxycholesterol 7-alpha-hydroxylase isoform X6

      Conserved Domains (1) summary
      cl41757
      Location:1 → 292
      cytochrome_P450; cytochrome P450 (CYP) superfamily

    2. XM_005627419.3 → XP_005627476.1  24-hydroxycholesterol 7-alpha-hydroxylase isoform X3

      UniProtKB/TrEMBL
      A0A8C0SF75
      Conserved Domains (1) summary
      cl41757
      Location:1 → 439
      cytochrome_P450; cytochrome P450 (CYP) superfamily

    3. XM_005627418.4 → XP_005627475.1  24-hydroxycholesterol 7-alpha-hydroxylase isoform X1

      UniProtKB/TrEMBL
      A0A8C0SF29, A0A8C0SF75, A0A8I3RX90
      Conserved Domains (1) summary
      cd20635
      Location:49 → 507
      CYP39A1; cytochrome P450 family 39, subfamily A, polypeptide 1

    4. XM_538946.7 → XP_538946.2  24-hydroxycholesterol 7-alpha-hydroxylase isoform X2

      UniProtKB/TrEMBL
      A0A8C0MF94, A0A8C0R040, A0A8I3NQ76, A0A8P0S869
      Conserved Domains (1) summary
      cd20635
      Location:49 → 462
      CYP39A1; cytochrome P450 family 39, subfamily A, polypeptide 1

    5. XM_014118491.1 → XP_013973966.1  24-hydroxycholesterol 7-alpha-hydroxylase isoform X5

      Conserved Domains (1) summary
      cl41757
      Location:1 → 341
      cytochrome_P450; cytochrome P450 (CYP) superfamily

    6. XM_014118490.2 → XP_013973965.1  24-hydroxycholesterol 7-alpha-hydroxylase isoform X4

      Conserved Domains (1) summary
      cl41757
      Location:1 → 386
      cytochrome_P450; cytochrome P450 (CYP) superfamily
    Nucleotide Protein
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