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    dlt discs lost [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 46719, updated on 28-Oct-2024

    Summary

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    Official Symbol
    dltprovided by FlyBase
    Official Full Name
    discs lostprovided by FlyBase
    Primary source
    FLYBASE:FBgn0024510
    Locus tag
    Dmel_CG32315
    See related
    AllianceGenome:FB:FBgn0024510
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1977; CG32315; Discs lost; Dlt; DLT; Dmel\CG32315; dre1; l(3)04276; l(3)62Ba; l(3)dre1; Van
    Summary
    Involved in imaginal disc morphogenesis; olfactory behavior; and regulation of cell population proliferation. Located in cytoplasm. Is expressed in several structures, including ectoderm; embryonic/larval salivary gland; furrow canal; gut section; and spermatozoon. Human ortholog(s) of this gene implicated in congenital dyserythropoietic anemia and congenital dyserythropoietic anemia type Ia. Orthologous to human CDAN1 (codanin 1). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
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    Genomic context

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    See dlt in Genome Data Viewer
    Location:
    62B4-62B4; 3-1.0 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1789631..1795328, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1789631..1795328, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene alpha Spectrin Neighboring gene mitochondrial ribosomal protein L46 Neighboring gene antisense RNA:CR45834 Neighboring gene antisense RNA:CR45818 Neighboring gene Cell division cycle 37 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The genetic architecture of quantitative traits: lessons from Drosophila. Mackay TF. Curr Opin Genet Dev, 2004 Jun. PMID 15172667
    2. DPATJ plays a role in retinal morphogenesis and protects against light-dependent degeneration of photoreceptor cells in the Drosophila eye. Richard M, et al. Dev Dyn, 2006 Apr. PMID 16245332
    3. Discs-Large and Strabismus are functionally linked to plasma membrane formation. Lee OK, et al. Nat Cell Biol, 2003 Nov. PMID 14562058, Free PMC Article
    4. Vanaso is a candidate quantitative trait gene for Drosophila olfactory behavior. Fanara JJ, et al. Genetics, 2002 Nov. PMID 12454076, Free PMC Article
    5. Cell shape and interaction defects in alpha-spectrin mutants of Drosophila melanogaster. Lee JK, et al. J Cell Biol, 1993 Dec. PMID 8276898, Free PMC Article

    See all (64) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in chromatin organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in imaginal disc morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in morphogenesis of a polarized epithelium TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in olfactory behavior IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    discs lost
    Names
    CG32315-PA
    dlt-PA
    lethal(3)62Ba
    vanaso

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      1789631..1795328 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167916.3 → NP_728672.1  discs lost [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728672.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8T626, Q8T627, Q9W084
      Related
      FBpp0072673
      Conserved Domains (1) summary
      pfam15296
      Location:788 → 908
      Codanin-1_C; Codanin-1 C-terminus
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8T626.2 Q8T626

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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