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    l(2)dtl lethal-(2)-denticleless [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 46326, updated on 2-Nov-2024

    Summary

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    Official Symbol
    l(2)dtlprovided by FlyBase
    Official Full Name
    lethal-(2)-denticlelessprovided by FlyBase
    Primary source
    FLYBASE:FBgn0013548
    Locus tag
    Dmel_CG11295
    See related
    AllianceGenome:FB:FBgn0013548
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cdt2; Cdt2; CG11295; Dmel\CG11295; DTL83; L2DTL
    Summary
    Predicted to enable protein-macromolecule adaptor activity. Predicted to be involved in mitotic G2 DNA damage checkpoint signaling and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in nucleus. Is expressed in organism. Orthologous to human DTL (denticleless E3 ubiquitin protein ligase homolog). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See l(2)dtl in Genome Data Viewer
    Location:
    59F6-59F6; 2-104 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23702477..23705403)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19590000..19592926)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene angel Neighboring gene mitochondrial ribosomal protein L43 Neighboring gene salivary glands marred Neighboring gene ALG3, alpha-1,3- mannosyltransferase Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45326

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of null and hypomorphic alleles of the Drosophila l(2)dtl/cdt2 gene: Larval lethality and male fertility. Sloan RS, et al. Fly (Austin), 2012 Jul-Sep. PMID 22722696
    2. Identification of a novel Drosophila melanogaster heat-shock gene, lethal(2)denticleless [l(2)dtl], coding for an 83-kDa protein. Kurzik-Dumke U, et al. Gene, 1996 Jun 1. PMID 8666267
    3. Identification of a novel Drosophila melanogaster gene, angel, a member of a nested gene cluster at locus 59F4,5. Kurzik-Dumke U, et al. Biochim Biophys Acta, 1996 Sep 11. PMID 8809105
    4. The Drosophila TIPE family member Sigmar interacts with the Ste20-like kinase Misshapen and modulates JNK signaling, cytoskeletal remodeling and autophagy. Chittaranjan S, et al. Biol Open, 2015 Apr 2. PMID 25836674, Free PMC Article
    5. Intrinsic negative cell cycle regulation provided by PIP box- and Cul4Cdt2-mediated destruction of E2f1 during S phase. Shibutani ST, et al. Dev Cell, 2008 Dec. PMID 19081076, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. L(2)dtl is essential for Drosophila development.
      Title: Characterization of null and hypomorphic alleles of the Drosophila l(2)dtl/cdt2 gene: Larval lethality and male fertility.
    2. L2DTL and PCNA interact with CUL4/DDB1 complexes and are involved in CDT1 degradation after DNA damage.
      Title: L2DTL/CDT2 interacts with the CUL4/DDB1 complex and PCNA and regulates CDT1 proteolysis in response to DNA damage.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein-macromolecule adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitotic G2 DNA damage checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    lethal-(2)-denticleless
    Names
    CG11295-PA
    l(2)dtl-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      23702477..23705403
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080132.3 → NP_524871.1  lethal-(2)-denticleless [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524871.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24371, Q9W1K9
      Related
      FBpp0071994
      Conserved Domains (3) summary
      COG2319
      Location:27 → 442
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:53 → 99
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:52 → 393
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q24371.2 Q24371

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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