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    rps6ka1.L ribosomal protein S6 kinase A1 L homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 445821, updated on 4-Nov-2024

    Summary

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    Official Symbol
    rps6ka1.L
    Official Full Name
    ribosomal protein S6 kinase A1 L homeolog
    Primary source
    Xenbase:XB-GENE-479500
    Locus tag
    XELAEV_18012109mg
    See related
    EnsemblRapid:ENSXLAG00005029551 AllianceGenome:Xenbase:XB-GENE-479500
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    rsk; hu-1; rsk1; rps6ka1; mapkapk1a
    Summary
    Predicted to enable ATP binding activity; magnesium ion binding activity; and protein kinase activity. Predicted to act upstream of or within intracellular signal transduction; peptidyl-serine phosphorylation; and positive regulation of DNA-templated transcription. Orthologous to human RPS6KA1 (ribosomal protein S6 kinase A1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See rps6ka1.L in Genome Data Viewer
    Location:
    chromosome: 2L
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 2L NC_054373.1 (61202706..61266587, complement)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 2L NC_030726.1 (58681267..58745147, complement)

    Chromosome 2L - NC_054373.1Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol glycan anchor biosynthesis class V S homeolog Neighboring gene AT-rich interaction domain 1A L homeolog Neighboring gene high mobility group nucleosomal binding domain 2 L homeolog Neighboring gene dehydrodolichyl diphosphate synthase subunit L homeolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Xenopus ribosomal protein S6 kinase has two apparent kinase domains that are each similar to distinct protein kinases. Jones SW, et al. Proc Natl Acad Sci U S A, 1988 May. PMID 3368449, Free PMC Article
    2. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC81220

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within peptidyl-serine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal protein S6 kinase 2 beta
    Names
    P90-RSK
    S6 kinase II beta
    S6KII-beta
    ribosomal protein S6 kinase II beta
    ribosomal protein S6 kinase, 90kDa, polypeptide 1 L homeolog
    NP_001086421.1
    XP_018100584.1
    XP_018100585.1
    XP_041436948.1
    XP_041436949.1
    XP_041436950.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001092952.1 → NP_001086421.1  ribosomal protein S6 kinase 2 beta

      See identical proteins and their annotated locations for NP_001086421.1

      Status: PROVISIONAL

      Source sequence(s)
      BC071102
      UniProtKB/Swiss-Prot
      P10666
      UniProtKB/TrEMBL
      A0A974DM47, Q6GR32
      Related
      ENSXLAP00005088975.1, ENSXLAT00005090644.1
      Conserved Domains (4) summary
      smart00220
      Location:62 → 321
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05582
      Location:66 → 382
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      pfam00069
      Location:416 → 673
      Pkinase; Protein kinase domain
      cl21453
      Location:414 → 704
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054373.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      61202706..61266587 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_041581014.1 → XP_041436948.1  ribosomal protein S6 kinase 2 beta isoform X1

      UniProtKB/Swiss-Prot
      P10666
      UniProtKB/TrEMBL
      A0A8J1M5I6
      Related
      ENSXLAP00005089556.1, ENSXLAT00005091225.1
      Conserved Domains (2) summary
      cd05582
      Location:106 → 422
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cl21453
      Location:454 → 744
      PKc_like; Protein Kinases, catalytic domain

    2. XM_018245095.2 → XP_018100584.1  ribosomal protein S6 kinase 2 beta isoform X4

      UniProtKB/Swiss-Prot
      P10666
      UniProtKB/TrEMBL
      A0A8J0UC46
      Related
      ENSXLAP00005089721.1, ENSXLAT00005091392.1

    3. XM_041581015.1 → XP_041436949.1  ribosomal protein S6 kinase 2 beta isoform X2

      UniProtKB/Swiss-Prot
      P10666
      UniProtKB/TrEMBL
      A0A8J1M5I8
      Conserved Domains (2) summary
      cd05582
      Location:100 → 416
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cl21453
      Location:448 → 738
      PKc_like; Protein Kinases, catalytic domain

    4. XM_018245096.2 → XP_018100585.1  ribosomal protein S6 kinase 2 beta isoform X5

      UniProtKB/Swiss-Prot
      P10666
      UniProtKB/TrEMBL
      A0A8J0U3Y1
      Related
      ENSXLAP00005089406.1, ENSXLAT00005091075.1

    5. XM_041581016.1 → XP_041436950.1  ribosomal protein S6 kinase 2 beta isoform X3

      UniProtKB/Swiss-Prot
      P10666
      UniProtKB/TrEMBL
      A0A8J1M7C9
      Related
      ENSXLAP00005088426.1, ENSXLAT00005090087.1
      Conserved Domains (2) summary
      cd05582
      Location:67 → 383
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cl21453
      Location:415 → 705
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P10666.1 GenPept UniProtKB/Swiss-Prot:P10666

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