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    tbxt.L T-box transcription factor Tr L homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 432248, updated on 4-Nov-2024

    Summary

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    Official Symbol
    tbxt.L
    Official Full Name
    T-box transcription factor Tr L homeolog
    Primary source
    Xenbase:XB-GENE-6255736
    Locus tag
    XELAEV_18026860mg
    See related
    EnsemblRapid:ENSXLAG00005028934 AllianceGenome:Xenbase:XB-GENE-6255736
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    bu; tb; bra; ntl; t-a; t-b; t.L; t.S; Xbra; X-bra; Xbra2; brachyury; Xbrachyury
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to act upstream of or within several processes, including mesoderm formation; regulation of DNA-templated transcription; and somitogenesis. Predicted to be located in nucleus. Is expressed in ectoderm; mesoderm; and nervous system. Human ortholog(s) of this gene implicated in neural tube defect. Orthologous to human TBXT (T-box transcription factor T). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See tbxt.L in Genome Data Viewer
    Location:
    chromosome: 5L
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 5L NC_054379.1 (57442347..57449535, complement)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 5L NC_030732.1 (56206032..56213226, complement)

    Chromosome 5L - NC_054379.1Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 10A L homeolog Neighboring gene T, brachyury homolog, gene 2 S homeolog Neighboring gene proline rich 18 L homeolog Neighboring gene SFT2 domain containing 1 L homeolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell fate specification IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within heart morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mesoderm formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within somitogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    T-box transcription factor Tr L homeolog
    Names
    T brachyury transcription factor L homeolog
    T brachyury transcription factor S homeolog
    T, brachyury homolog b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001091696.1 → NP_001085165.1  T-box transcription factor Tr L homeolog

      See identical proteins and their annotated locations for NP_001085165.1

      Status: PROVISIONAL

      Source sequence(s)
      BC072224
      UniProtKB/TrEMBL
      A0A974HJR2, Q6INQ0
      Related
      ENSXLAP00005086271.1, ENSXLAT00005087934.1
      Conserved Domains (2) summary
      cd00182
      Location:40 → 221
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
      pfam10267
      Location:320 → 412
      Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054379.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      57442347..57449535 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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