sp3 spermathreecae [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: sp3provided by FlyBase
Official Full Name: spermathreecaeprovided by FlyBase
Primary source: FLYBASE:FBgn0038890
Locus tag: Dmel_CG7956
See related: AllianceGenome:FB:FBgn0038890
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG7956; Dmel\CG7956; INPP5F
Summary: Predicted to enable phosphatidylinositol-4-phosphate phosphatase activity. Predicted to be involved in phosphatidylinositol dephosphorylation and regulation of endocytic recycling. Predicted to be active in clathrin-coated endocytic vesicle and early endosome. Is expressed in adult head. Orthologous to human INPP5F (inositol polyphosphate-5-phosphatase F). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: 93E4-93E4; 3-72 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (21520928..21528598)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (17346650..17354320)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-4-phosphate phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in phosphatidylinositol dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of endocytic recycling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of spermathecum morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in clathrin-coated endocytic vesicle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in early endosome	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: spermathreecae

Names: CG7956-PA; CG7956-PD; CG7956-PE; CG7956-PF; CG7956-PG; sp3-PA; sp3-PD; sp3-PE; sp3-PF; sp3-PG

NP_001014644.3

EC 3.1.3.-

NP_001036740.2

EC 3.1.3.-

NP_001163675.1

EC 3.1.3.-

NP_001163676.1

EC 3.1.3.-

NP_650972.2

EC 3.1.3.-

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

21520928..21528598

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001170204.2 → NP_001163675.1 spermathreecae, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163675.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JIS1, Q8MRH8

Conserved Domains (3) summary

COG5329
Location:197 → 565

COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]

pfam02383
Location:174 → 413

Syja_N; SacI homology domain

pfam12456
Location:591 → 696

hSac2; Inositol phosphatase
NM_001170205.2 → NP_001163676.1 spermathreecae, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163676.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JIS2

Conserved Domains (2) summary

COG5329
Location:197 → 586

COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]

pfam02383
Location:174 → 413

Syja_N; SacI homology domain
NM_001043275.2 → NP_001036740.2 spermathreecae, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001036740.2

Status: REVIEWED

UniProtKB/TrEMBL

Q0KI33, Q8MRH8

Conserved Domains (3) summary

COG5329
Location:197 → 586

COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]

pfam02383
Location:174 → 413

Syja_N; SacI homology domain

pfam12456
Location:663 → 768

hSac2; Inositol phosphatase
NM_001014644.3 → NP_001014644.3 spermathreecae, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014644.3

Status: REVIEWED

UniProtKB/TrEMBL

Q59DV6, Q8MRH8

Conserved Domains (3) summary

COG5329
Location:197 → 565

COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]

pfam02383
Location:174 → 413

Syja_N; SacI homology domain

pfam12456
Location:591 → 696

hSac2; Inositol phosphatase
NM_142715.3 → NP_650972.2 spermathreecae, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_650972.2

Status: REVIEWED

UniProtKB/TrEMBL

Q8MRH8, Q9VD98

Conserved Domains (3) summary

COG5329
Location:197 → 565

COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]

pfam02383
Location:174 → 413

Syja_N; SacI homology domain

pfam12456
Location:591 → 696

hSac2; Inositol phosphatase