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    OVALX ovalbumin-related protein X (SERPINB14C) [ Gallus gallus (chicken) ]

    Gene ID: 420898, updated on 10-Oct-2024

    Summary

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    Official Symbol
    OVALXprovided by CGNC
    Official Full Name
    ovalbumin-related protein X (SERPINB14C)provided by CGNC
    Primary source
    CGNC:51367
    See related
    Ensembl:ENSGALG00010011714
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    SERPINB11; SERPINB14C
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    Genomic context

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    See OVALX in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 2 NC_052533.1 (67456353..67463354, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 2 NC_052574.1 (67429566..67436588, complement)

    Chromosome 2 - NC_052533.1Genomic Context describing neighboring genes Neighboring gene ovalbumin (SERPINB14) Neighboring gene ovalbumin-related protein Y (SERPINB14B) Neighboring gene uncharacterized LOC107052628 Neighboring gene serpin family B member 12 Neighboring gene serpin family B member 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Migration of chicken egg-white protein ovalbumin-related protein X and its alteration in heparin-binding affinity during embryogenesis of fertilized egg. Akazawa T, et al. Poult Sci, 2019 Oct 1. PMID 31222360
    2. Ovalbumin-related protein X is a heparin-binding ov-serpin exhibiting antimicrobial activities. Réhault-Godbert S, et al. J Biol Chem, 2013 Jun 14. PMID 23615912, Free PMC Article
    3. Avian SERPINB11 gene: characteristics, tissue-specific expression, and regulation of expression by estrogen. Lim W, et al. Biol Reprod, 2011 Dec. PMID 21849706
    4. The ovalbumin gene family: structure of the X gene and evolution of duplicated split genes. Heilig R, et al. Cell, 1980 Jul. PMID 7418002
    5. The Family Secrets of Avian Egg-Specific Ovalbumin and Its Related Proteins Y and X. Da Silva M, et al. Biol Reprod, 2015 Sep. PMID 26157071

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Although heparin-binding ability of egg-white OVAX slightly decreases during embryogenesis, OVAX incorporated into embryo can retain heparin-binding affinity.
      Title: Migration of chicken egg-white protein ovalbumin-related protein X and its alteration in heparin-binding affinity during embryogenesis of fertilized egg.
    2. Considering the antibacterial activities of OVAX, this protein might play a role in egg defense
      Title: The Family Secrets of Avian Egg-Specific Ovalbumin and Its Related Proteins Y and X.
    3. OVAX and ovalbumin, although highly similar in sequence, have peculiar sequential and/or structural features that are likely to impact their respective biological functions.
      Title: Ovalbumin-related protein X is a heparin-binding ov-serpin exhibiting antimicrobial activities.
    4. expressed only in epithelial cells of the chicken oviduct, implicated in regulation of oviduct development
      Title: Avian SERPINB11 gene: characteristics, tissue-specific expression, and regulation of expression by estrogen.
    5. SERPINB11 has a role in ovarian endometrioid carcinoma in chickens and human
      Title: Avian SERPINB11 gene: a marker for ovarian endometrioid cancer in chickens.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ovalbumin-related protein X
    Names
    clade B (ovalbumin) pseudogene 1
    gene X protein
    serpin peptidase inhibitor, clade B (ovalbumin), member 11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001276386.2 → NP_001263315.2  ovalbumin-related protein X

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000040
      UniProtKB/TrEMBL
      A0A8V0Y614
      Related
      ENSGALP00010016079.1, ENSGALT00010028030.1

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      67456353..67463354 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015282174.3 → XP_015137660.2  ovalbumin-related protein X isoform X2

      UniProtKB/TrEMBL
      R9TNA6
      Conserved Domains (1) summary
      cl38926
      Location:11 → 402
      serpin; SERine Proteinase INhibitors (serpin) family

    2. XM_015282173.3 → XP_015137659.2  ovalbumin-related protein X isoform X1

      UniProtKB/TrEMBL
      A0A8V0YAS0
      Related
      ENSGALP00010016073.1, ENSGALT00010028022.1
      Conserved Domains (1) summary
      cl38926
      Location:70 → 456
      serpin; SERine Proteinase INhibitors (serpin) family

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052574.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      67429566..67436588 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046911434.1 → XP_046767390.1  ovalbumin-related protein X isoform X2

    2. XM_046911433.1 → XP_046767389.1  ovalbumin-related protein X isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P01013.1 GenPept UniProtKB/Swiss-Prot:P01013

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials