U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    MITF melanocyte inducing transcription factor [ Canis lupus familiaris (dog) ]

    Gene ID: 415126, updated on 17-Aug-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    MITFprovided by VGNC
    Official Full Name
    melanocyte inducing transcription factorprovided by VGNC
    Primary source
    VGNC:VGNC:43248
    See related
    Ensembl:ENSCAFG00845009666
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Also known as
    MITF-H; MITF-M
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See MITF in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 20 NC_051824.1 (21883312..22101930, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 20 NC_006602.4 (21826585..21857697, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 20 NC_049241.1 (21991588..22022704, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 20 NC_049280.1 (21572611..21603715, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 20 NC_049761.1 (21921161..21952266, complement)

    Chromosome 20 - NC_051824.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119864576 Neighboring gene uncharacterized LOC102155999 Neighboring gene uncharacterized LOC119864577 Neighboring gene uncharacterized LOC119864578

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Sequence variants of the canine melanocyte inducing transcription factor (MITF) locus reveal a common MITF-A processed pseudogene. Brancalion L, et al. Anim Genet, 2021 Oct. PMID 34165209
    2. TGF-β Negatively Regulates Mitf-E Expression and Canine Osteoclastogenesis. Asai K, et al. Biochem Genet, 2018 Oct. PMID 29680988
    3. A role of the microphthalmia-associated transcription factor in congenital sensorineural deafness and eye pigmentation in Dalmatian dogs. Stritzel S, et al. J Anim Breed Genet, 2009 Feb. PMID 19207931
    4. Association of MITF with white spotting in Beagle crosses and Newfoundland dogs. Rothschild MF, et al. Anim Genet, 2006 Dec. PMID 17121617
    5. Genomic Regions Associated with Variation in Pigmentation Loss in Saddle Tan Beagles. Nord ME, et al. Genes (Basel), 2021 Feb 23. PMID 33672409, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sequence variants of the canine melanocyte inducing transcription factor (MITF) locus reveal a common MITF-A processed pseudogene.
      Title: Sequence variants of the canine melanocyte inducing transcription factor (MITF) locus reveal a common MITF-A processed pseudogene.
    2. Genomic Regions Associated with Variation in Pigmentation Loss in Saddle Tan Beagles.
      Title: Genomic Regions Associated with Variation in Pigmentation Loss in Saddle Tan Beagles.
    3. Results show that Mitf-E but not Mitf-A isoform expression is induced during osteoclastogenesis.
      Title: TGF-β Negatively Regulates Mitf-E Expression and Canine Osteoclastogenesis.
    4. MITF might play a role in congenital sensorineural deafness and blue eye colour in Dalmatian dogs.
      Title: A role of the microphthalmia-associated transcription factor in congenital sensorineural deafness and eye pigmentation in Dalmatian dogs.
    5. MITF on dog chromosome 20 shows association with white spotting (inherited recessively) in Beagle and Newfoundland dogs.
      Title: Association of MITF with white spotting in Beagle crosses and Newfoundland dogs.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in melanocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    microphthalmia-associated transcription factor
    Names
    melanogenesis associated transcription factor

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003337.1 → NP_001003337.1  microphthalmia-associated transcription factor

      See identical proteins and their annotated locations for NP_001003337.1

      Status: PROVISIONAL

      Source sequence(s)
      AY240952
      UniProtKB/TrEMBL
      A0A8C0YSP0, F1PY12, Q6UUT7, Q864F3
      Related
      ENSCAFP00845013465.1, ENSCAFT00845017276.1
      Conserved Domains (3) summary
      cd00083
      Location:202 → 262
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      pfam11851
      Location:290 → 403
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:11 → 87
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051824.1 Reference ROS_Cfam_1.0

      Range
      21883312..22101930 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038426380.1 → XP_038282308.1  microphthalmia-associated transcription factor isoform X4

      UniProtKB/TrEMBL
      A0A8C0S2P6, A0A8P0PS65
      Conserved Domains (3) summary
      cd18926
      Location:293 → 396
      bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins
      pfam11851
      Location:390 → 509
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:55 → 193
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

    2. XM_038426378.1 → XP_038282306.1  microphthalmia-associated transcription factor isoform X2

      UniProtKB/TrEMBL
      A0A8C0S2P6, A0A8P0PS65
      Conserved Domains (3) summary
      cd18926
      Location:299 → 402
      bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins
      pfam11851
      Location:396 → 515
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:55 → 193
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

    3. XM_038426385.1 → XP_038282313.1  microphthalmia-associated transcription factor isoform X9

      UniProtKB/TrEMBL
      A0A8I3NE18, A0A8P0NY70
      Related
      ENSCAFP00845013398.1, ENSCAFT00845017193.1
      Conserved Domains (3) summary
      cd18926
      Location:224 → 327
      bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins
      pfam11851
      Location:321 → 440
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:56 → 118
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

    4. XM_038426379.1 → XP_038282307.1  microphthalmia-associated transcription factor isoform X3

      UniProtKB/TrEMBL
      A0A8C0KDQ1, A0A8C0S2P6, A0A8I3N265, A0A8P0PS65
      Related
      ENSCAFP00845013351.1, ENSCAFT00845017138.1
      Conserved Domains (3) summary
      cd18926
      Location:294 → 397
      bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins
      pfam11851
      Location:391 → 510
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:56 → 194
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

    5. XM_038426377.1 → XP_038282305.1  microphthalmia-associated transcription factor isoform X1

      UniProtKB/TrEMBL
      A0A8C0MLN0, A0A8C0S2P6, A0A8P0PS65, A0A8P0SRD5
      Conserved Domains (3) summary
      cd18926
      Location:300 → 403
      bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins
      pfam11851
      Location:397 → 516
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:56 → 194
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

    6. XM_038426384.1 → XP_038282312.1  microphthalmia-associated transcription factor isoform X8

      UniProtKB/TrEMBL
      A0A8C0S2Z1
      Conserved Domains (3) summary
      cd18926
      Location:268 → 371
      bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins
      pfam11851
      Location:365 → 484
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:24 → 162
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

    7. XM_038426383.1 → XP_038282311.1  microphthalmia-associated transcription factor isoform X7

      UniProtKB/TrEMBL
      A0A8C0S2Z1
      Conserved Domains (3) summary
      cd18926
      Location:278 → 381
      bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins
      pfam11851
      Location:375 → 494
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:40 → 178
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

    8. XM_038426381.1 → XP_038282309.1  microphthalmia-associated transcription factor isoform X5

      UniProtKB/TrEMBL
      A0A8C0MRU3, A0A8C0S2Z1, A0A8I3ND12
      Related
      ENSCAFP00845013307.1, ENSCAFT00845017088.1
      Conserved Domains (3) summary
      cd18926
      Location:284 → 387
      bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins
      pfam11851
      Location:381 → 500
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:40 → 178
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

    9. XM_038426382.1 → XP_038282310.1  microphthalmia-associated transcription factor isoform X6

      UniProtKB/TrEMBL
      A0A8C0S2Z1
      Conserved Domains (3) summary
      cd18926
      Location:283 → 386
      bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins
      pfam11851
      Location:380 → 499
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:39 → 177
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

    10. XM_038426386.1 → XP_038282314.1  microphthalmia-associated transcription factor isoform X10

      UniProtKB/TrEMBL
      Q6UUT7
      Conserved Domains (3) summary
      cd18926
      Location:187 → 290
      bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins
      pfam11851
      Location:284 → 403
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:11 → 87
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049280.1 Alternate UMICH_Zoey_3.1

      Range
      21572611..21603715 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049761.1 Alternate UNSW_CanFamBas_1.0

      Range
      21921161..21952266 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049241.1 Alternate UU_Cfam_GSD_1.0

      Range
      21991588..22022704 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006602.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      21826585..21857697 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials