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    Or85b Odorant receptor 85b [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41007, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Or85bprovided by FlyBase
    Official Full Name
    Odorant receptor 85bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037590
    Locus tag
    Dmel_CG11735
    See related
    AllianceGenome:FB:FBgn0037590
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    85A.1; 85b; CG11735; Dmel\CG11735; DmOr85b; DmOR85b; DOR115; OR85b
    Summary
    Enables ionotropic olfactory receptor activity and odorant binding activity. Involved in detection of chemical stimulus involved in sensory perception of smell. Part of cation channel complex. Is active in plasma membrane. Is expressed in adult olfactory receptor neuron Or85b/98b and antennal basiconic sensillum ab3. [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
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    Genomic context

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    See Or85b in Genome Data Viewer
    Location:
    85A2-85A2; 3-48 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (8510077..8511358, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (4335799..4337080, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Odorant-binding protein 85a Neighboring gene long non-coding RNA:CR46125 Neighboring gene long non-coding RNA:CR46228 Neighboring gene Odorant receptor 85c

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transmembrane segment 3 of Drosophila melanogaster odorant receptor subunit 85b contributes to ligand-receptor interactions. Nichols AS, et al. J Biol Chem, 2010 Apr 16. PMID 20147286, Free PMC Article
    2. Cell-free expression, purification, and ligand-binding analysis of Drosophila melanogaster olfactory receptors DmOR67a, DmOR85b and DmORCO. Tegler LT, et al. Sci Rep, 2015 Jan 19. PMID 25597985, Free PMC Article
    3. Short-term memory trace mediated by termination kinetics of olfactory receptor. Boyle SM, et al. Sci Rep, 2016 Feb 1. PMID 26830661, Free PMC Article
    4. What reaches the antenna? How to calibrate odor flux and ligand-receptor affinities. Andersson MN, et al. Chem Senses, 2012 Jun. PMID 22362868
    5. Intensity invariant dynamics and odor-specific latencies in olfactory receptor neuron response. Martelli C, et al. J Neurosci, 2013 Apr 10. PMID 23575828, Free PMC Article

    See all (70) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. we show that insect ORs(DmOR67a, DmOR85b and DmORCO) and their co-receptor can be expressed in an E. coli cell-free system
      Title: Cell-free expression, purification, and ligand-binding analysis of Drosophila melanogaster olfactory receptors DmOR67a, DmOR85b and DmORCO.
    2. Using the substituted cysteine accessibility method, we identified residues 146-150 of OR85b, located at the predicted interface between transmembrane segment 3 and extracellular loop 2, as playing a role in odorant (2-heptanone) activation.
      Title: Transmembrane segment 3 of Drosophila melanogaster odorant receptor subunit 85b contributes to ligand-receptor interactions.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ionotropic olfactory receptor activity HDA PubMed 
    enables ionotropic olfactory receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables odorant binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables odorant binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables odorant binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables odorant binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables olfactory receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables olfactory receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in detection of chemical stimulus involved in sensory perception of smell HDA PubMed 
    involved_in detection of chemical stimulus involved in sensory perception of smell IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in detection of chemical stimulus involved in sensory perception of smell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sensory perception of smell IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of cation channel complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in dendrite membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    odorant receptor 85b
    Names
    CG11735-PA
    Or85b-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      8510077..8511358 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079555.2 → NP_524279.2  odorant receptor 85b [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524279.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VHQ7
      Related
      FBpp0081383, FBtr0081900
      Conserved Domains (1) summary
      pfam02949
      Location:64 → 378
      7tm_6; 7tm Odorant receptor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VHQ7.2 Q9VHQ7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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