lta4h leukotriene A4 hydrolase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: lta4hprovided by ZNC
Official Full Name: leukotriene A4 hydrolaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2477
See related: Ensembl:ENSDARG00000006029 AllianceGenome:ZFIN:ZDB-GENE-040426-2477
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:85809
Summary: Predicted to enable aminopeptidase activity; epoxide hydrolase activity; and leukotriene-A4 hydrolase activity. Acts upstream of or within several processes, including epiboly involved in gastrulation with mouth forming second; neutrophil chemotaxis; and response to bacterium. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. Is expressed in intestinal bulb; macrophage; and neutrophil. Orthologous to human LTA4H (leukotriene A4 hydrolase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	4	NC_007115.7 (7653612..7673131, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	4	NC_007115.6 (7644983..7664502, complement)

Chromosome 4 - NC_007115.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

lta4h mutations confer hypersusceptibility to mycobacterial infection by redirecting eicosanoid substrates to anti-inflammatory lipoxins.
Title: The lta4h locus modulates susceptibility to mycobacterial infection in zebrafish and humans.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables aminopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables epoxide hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables leukotriene-A4 hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables leukotriene-A4 hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within epiboly involved in gastrulation with mouth forming second	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in leukotriene biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within leukotriene biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neutrophil chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptide catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: leukotriene A-4 hydrolase

NP_998451.1

EC 3.3.2.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213286.1 → NP_998451.1 leukotriene A-4 hydrolase

See identical proteins and their annotated locations for NP_998451.1

Status: PROVISIONAL

Source sequence(s)

BC068394

UniProtKB/TrEMBL

Q6NUX4

Related

ENSDARP00000011882.6, ENSDART00000028171.7

Conserved Domains (3) summary

cd09599
Location:18 → 449

M1_LTA4H; Peptidase M1 family contains leukotriene A4 hydrolase

TIGR02411
Location:18 → 607

leuko_A4_hydro; leukotriene A-4 hydrolase/aminopeptidase

pfam09127
Location:467 → 606

Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal