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    pnp4b purine nucleoside phosphorylase 4b [ Danio rerio (zebrafish) ]

    Gene ID: 402940, updated on 2-Nov-2024

    Summary

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    Official Symbol
    pnp4bprovided by ZNC
    Official Full Name
    purine nucleoside phosphorylase 4bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1887
    See related
    Ensembl:ENSDARG00000029230 AllianceGenome:ZFIN:ZDB-GENE-040426-1887
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:77825
    Summary
    Predicted to enable purine-nucleoside phosphorylase activity. Predicted to act upstream of or within nucleoside metabolic process. Predicted to be active in cytoplasm. Is expressed in intestinal bulb and liver. Human ortholog(s) of this gene implicated in purine nucleoside phosphorylase deficiency and purine-pyrimidine metabolic disorder. Orthologous to human PNP (purine nucleoside phosphorylase). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See pnp4b in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (36807924..36834517, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (36854040..36880633, complement)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene phosphoinositide-3-kinase, regulatory subunit 4 Neighboring gene 2,4-dienoyl CoA reductase 1, mitochondrial Neighboring gene calbindin 1 Neighboring gene tyrosyl-DNA phosphodiesterase 2 Neighboring gene KIAA0319

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Interplay between Foxd3 and Mitf regulates cell fate plasticity in the zebrafish neural crest. Curran K, et al. Dev Biol, 2010 Aug 1. PMID 20460180, Free PMC Article
    2. pnp4a Is the Causal Gene of the Medaka Iridophore Mutant guanineless. Kimura T, et al. G3 (Bethesda), 2017 Apr 3. PMID 28258112, Free PMC Article
    3. Identification of estrogen target genes during zebrafish embryonic development through transcriptomic analysis. Hao R, et al. PLoS One, 2013. PMID 24223173, Free PMC Article
    4. Enhanced transcription of complement and coagulation genes in the absence of adaptive immunity. Jima DD, et al. Mol Immunol, 2009 Apr. PMID 19200601, Free PMC Article
    5. HNF factors form a network to regulate liver-enriched genes in zebrafish. Cheng W, et al. Dev Biol, 2006 Jun 15. PMID 16631158

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC77825, MGC103595

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables purine-nucleoside phosphorylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables purine-nucleoside phosphorylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within nucleobase-containing compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within nucleoside metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    purine nucleoside phosphorylase 4b
    NP_991206.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_205643.1 → NP_991206.1  purine nucleoside phosphorylase 4b

      See identical proteins and their annotated locations for NP_991206.1

      Status: PROVISIONAL

      Source sequence(s)
      BC065875
      UniProtKB/TrEMBL
      A0A8M1PJX9, Q6P016
      Related
      ENSDARP00000041992.5, ENSDART00000041993.7
      Conserved Domains (2) summary
      COG0005
      Location:25 → 286
      XapA; Purine nucleoside phosphorylase [Nucleotide transport and metabolism]
      PRK08202
      Location:18 → 286
      PRK08202; purine nucleoside phosphorylase; Provisional

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      36807924..36834517 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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