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    LINC00114 long intergenic non-protein coding RNA 114 [ Homo sapiens (human) ]

    Gene ID: 400866, updated on 17-Sep-2024

    Summary

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    Official Symbol
    LINC00114provided by HGNC
    Official Full Name
    long intergenic non-protein coding RNA 114provided by HGNC
    Primary source
    HGNC:HGNC:1265
    See related
    Ensembl:ENSG00000223806 MIM:611723; AllianceGenome:HGNC:1265
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C21orf24; NCRNA00114
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See LINC00114 in Genome Data Viewer
    Location:
    21q22.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (38739021..38773477, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (37122806..37157258, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (40110945..40145401, complement)

    Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene ETS transcription factor ERG Neighboring gene ERG, ETS transcription factor breakpoint cluster recombination region Neighboring gene uncharacterized LOC105372802 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr21:39879001-39879501 Neighboring gene small nuclear ribonucleoprotein polypeptide G pseudogene 13 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr21:40051342-40052541 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr21:40055463-40056662 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18458 Neighboring gene uncharacterized LOC107985480 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr21:40159061-40160260 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:40176652-40177152 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13312 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13313 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13314 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13315 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13316 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr21:40182837-40184036 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr21:40185951-40187150 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:40194325-40194862 Neighboring gene ETS proto-oncogene 2, transcription factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. LINC00114 stimulates growth and glycolysis of esophageal cancer cells by recruiting EZH2 to enhance H3K27me3 of DLC1. Qin J, et al. Clin Epigenetics, 2022 Apr 12. PMID 35414117, Free PMC Article
    2. LINC00114 promoted nasopharyngeal carcinoma progression and radioresistance in vitro and in vivo through regulating ERK/JNK signaling pathway via targeting miR-203. Han YY, et al. Eur Rev Med Pharmacol Sci, 2020 Mar. PMID 32196600
    3. Identification of the 3-lncRNA Signature as a Prognostic Biomarker for Colorectal Cancer. Liu S, et al. Int J Mol Sci, 2020 Dec 8. PMID 33302562, Free PMC Article
    4. Detailed mapping of the ERG-ETS2 interval of human chromosome 21 and comparison with the region of conserved synteny on mouse chromosome 16. Owczarek CM, et al. Gene, 2004 Jan 7. PMID 14693372
    5. The DNA sequence of human chromosome 21. Hattori M, et al. Nature, 2000 May 18. PMID 10830953

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LINC00114 stimulates growth and glycolysis of esophageal cancer cells by recruiting EZH2 to enhance H3K27me3 of DLC1.
      Title: LINC00114 stimulates growth and glycolysis of esophageal cancer cells by recruiting EZH2 to enhance H3K27me3 of DLC1.
    2. LINC00114 promoted nasopharyngeal carcinoma progression and radioresistance in vitro and in vivo through regulating ERK/JNK signaling pathway via targeting miR-203.
      Title: LINC00114 promoted nasopharyngeal carcinoma progression and radioresistance in vitro and in vivo through regulating ERK/JNK signaling pathway via targeting miR-203.
    3. Identification of the 3-lncRNA Signature as a Prognostic Biomarker for Colorectal Cancer.
      Title: Identification of the 3-lncRNA Signature as a Prognostic Biomarker for Colorectal Cancer.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Markers

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_027065.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP001038, AY204746, BF063573
      Related
      ENST00000429621.1

    2. NR_027066.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP001038, AP001039, AY204745, BF063573

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

      Range
      38739021..38773477 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060945.1 Alternate T2T-CHM13v2.0

      Range
      37122806..37157258 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001001789.2: Suppressed sequence

      Description
      NM_001001789.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

    2. NR_027067.1: Suppressed sequence

      Description
      NR_027067.1: This RefSeq was removed because currently there is insufficient support for this transcript.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6XXX2.1 GenPept UniProtKB/Swiss-Prot:Q6XXX2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials