esr1.S estrogen receptor 1 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: esr1.S
Official Full Name: estrogen receptor 1 S homeolog
Primary source: Xenbase:XB-GENE-6255445
Locus tag: XELAEV_18029000mg
See related: EnsemblRapid:ENSXLAG00005007807 AllianceGenome:Xenbase:XB-GENE-6255445
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: XER; esr1; esr1b; nr3a1; xesr1; ERbeta; esr1-a; esr1-b; xesr-1; ERalpha; xlERalpha1; xlERalpha2
Summary: Predicted to enable several functions, including estrogen response element binding activity; nuclear estrogen receptor activity; and zinc ion binding activity. Predicted to act upstream of or within cellular response to estrogen stimulus; estrogen receptor signaling pathway; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); bone disease (multiple); breast cancer (multiple); type 2 diabetes mellitus; and vitiligo. Orthologous to human ESR1 (estrogen receptor 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 5S

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	5S	NC_054380.1 (40136271..40247358, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	5S	NC_030733.1 (39990039..40101342, complement)

Chromosome 5S - NC_054380.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables estrogen response element binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclear estrogen receptor activity	IEA Inferred from Electronic Annotation more info
enables nuclear receptor activity	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables steroid binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to estrogen stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within estrogen receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within steroid hormone receptor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: estrogen receptor 1 S homeolog

Names: bER alpha1; brain estrogen receptor alpha1; estrogen receptor 1 b; estrogen receptor alpha 2; gER alpha1; gonad estrogen receptor alpha1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001089615.2 → NP_001083084.2 estrogen receptor 1 S homeolog

See identical proteins and their annotated locations for NP_001083084.2

Status: PROVISIONAL

Source sequence(s)

AB435403

UniProtKB/TrEMBL

A0A974CQT9, B2NIY0

Conserved Domains (4) summary

cd06949
Location:301 → 538

NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)

cd07171
Location:174 → 255

NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers

pfam02159
Location:42 → 175

Oest_recep; Oestrogen receptor

pfam12743
Location:551 → 585

ESR1_C; Oestrogen-type nuclear receptor final C-terminal

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054380.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

40136271..40247358 complement

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GenBank, FASTA, Sequence Viewer (Graphics)