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    TNC tenascin C [ Sus scrofa (pig) ]

    Gene ID: 397460, updated on 17-Aug-2024

    Summary

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    Official Symbol
    TNCprovided by VGNC
    Official Full Name
    tenascin Cprovided by VGNC
    Primary source
    VGNC:VGNC:103192
    See related
    Ensembl:ENSSSCG00000005494
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Also known as
    JI; TN; HXB; GMEM; P230
    Expression
    Broad expression in lung (RPKM 36.2), spleen (RPKM 25.1) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See TNC in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 1 NC_010443.5 (255533235..255630381, complement)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 1 NC_010443.4 (286732751..286813962, complement)

    Chromosome 1 - NC_010443.5Genomic Context describing neighboring genes Neighboring gene TNF superfamily member 15 Neighboring gene TNF superfamily member 8 Neighboring gene uncharacterized LOC102161373 Neighboring gene ubiquitin-40S ribosomal protein S27a pseudogene Neighboring gene 60S acidic ribosomal protein P1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. Isolation and characterization of a 230 kDa protein (p230) specifically expressed in fetal brains: its involvement in neurite outgrowth from rat cerebral cortex neurons grown on monolayer of astrocytes. Wakatsuki S, et al. J Biochem, 1997 Dec. PMID 9498558
    2. Localization of the tenascin-C gene to pig chromosome 1. Garrido JJ, et al. Mamm Genome, 1995 Mar. PMID 7538362
    3. Assignment of the tenascin gene (HXB) to swine chromosome 1q21.1-->q21.3 by fluorescence in situ hybridization. Awata T, et al. Cytogenet Cell Genet, 1995. PMID 7530615
    4. Complete primary structure of porcine tenascin. Detection of tenascin transcripts in adult submaxillary glands. Nishi T, et al. Eur J Biochem, 1991 Dec 5. PMID 1722152
    5. Localization of a cryptic binding site for tenascin on fibronectin. Ingham KC, et al. J Biol Chem, 2004 Jul 2. PMID 15123658

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TNC does not appear to contribute directly to outflow resistance in the eye.
      Title: The effects of tenascin C knockdown on trabecular meshwork outflow resistance.
    2. TNC could be a potential candidate gene for meat quality traits in pigs.
      Title: Polymorphism and expression of the porcine Tenascin C gene associated with meat and carcass quality.
    3. tenascin binds to fibronectin at a cryptic binding site
      Title: Localization of a cryptic binding site for tenascin on fibronectin.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tenascin
    Names
    GP 150-225
    cytotactin
    glioma-associated-extracellular matrix antigen
    hexabrachion
    myotendinous antigen
    neuronectin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_214230.2 → NP_999395.2  tenascin precursor

      Status: VALIDATED

      Source sequence(s)
      AEMK02000005
      UniProtKB/Swiss-Prot
      P98142, Q29116
      Conserved Domains (5) summary
      cd00063
      Location:624 → 710
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00147
      Location:1525 → 1734
      Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
      pfam00041
      Location:1433 → 1505
      fn3; Fibronectin type III domain
      pfam01414
      Location:515 → 558
      DSL; Delta serrate ligand
      pfam18720
      Location:408 → 435
      EGF_Tenascin; Tenascin EGF domain

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010443.5 Reference Sscrofa11.1 Primary Assembly

      Range
      255533235..255630381 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021083193.1 → XP_020938852.1  tenascin isoform X18

      UniProtKB/TrEMBL
      A0A8D1J3Q8
      Conserved Domains (4) summary
      cd00063
      Location:751 → 837
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00147
      Location:1561 → 1770
      Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
      pfam07974
      Location:600 → 623
      EGF_2; EGF-like domain
      pfam00041
      Location:1469 → 1548
      fn3; Fibronectin type III domain

    2. XM_021083146.1 → XP_020938805.1  tenascin isoform X8

      UniProtKB/TrEMBL
      A0A8D0ZSZ7
      Related
      ENSSSCP00000005891.5, ENSSSCT00000006041.5
      Conserved Domains (4) summary
      cd00063
      Location:751 → 837
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00147
      Location:2016 → 2225
      Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
      pfam07974
      Location:600 → 623
      EGF_2; EGF-like domain
      pfam00041
      Location:1924 → 2003
      fn3; Fibronectin type III domain

    3. XM_021083130.1 → XP_020938789.1  tenascin isoform X5

      UniProtKB/TrEMBL
      A0A287AKU7, A0A8D0ZT49
      Related
      ENSSSCP00000044523.1, ENSSSCT00000036896.3
      Conserved Domains (4) summary
      cd00063
      Location:751 → 837
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00147
      Location:2107 → 2316
      Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
      pfam07974
      Location:600 → 623
      EGF_2; EGF-like domain
      pfam00041
      Location:2015 → 2094
      fn3; Fibronectin type III domain

    4. XM_021083107.1 → XP_020938766.1  tenascin isoform X2

      UniProtKB/TrEMBL
      A0A8D0ZYS3
      Related
      ENSSSCP00000027784.3, ENSSSCT00000026819.4
      Conserved Domains (4) summary
      cd00063
      Location:751 → 837
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00147
      Location:2199 → 2408
      Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
      pfam07974
      Location:597 → 623
      EGF_2; EGF-like domain
      pfam00041
      Location:2107 → 2186
      fn3; Fibronectin type III domain

    5. XM_021083096.1 → XP_020938755.1  tenascin isoform X1

      UniProtKB/TrEMBL
      A0A8D0ZYS3
      Conserved Domains (4) summary
      cd00063
      Location:780 → 866
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00147
      Location:2228 → 2437
      Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
      pfam07974
      Location:626 → 652
      EGF_2; EGF-like domain
      pfam00041
      Location:2136 → 2215
      fn3; Fibronectin type III domain

    6. XM_021083117.1 → XP_020938776.1  tenascin isoform X3

      UniProtKB/TrEMBL
      A0A8D1LTU4
      Related
      ENSSSCP00000059023.2, ENSSSCT00000058254.3
      Conserved Domains (4) summary
      cd00063
      Location:780 → 866
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00147
      Location:2137 → 2346
      Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
      pfam07974
      Location:629 → 652
      EGF_2; EGF-like domain
      pfam00041
      Location:2045 → 2124
      fn3; Fibronectin type III domain

    7. XM_021083120.1 → XP_020938779.1  tenascin isoform X4

      UniProtKB/TrEMBL
      A0A8D0ZT49
      Conserved Domains (4) summary
      cd00063
      Location:780 → 866
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00147
      Location:2136 → 2345
      Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
      pfam07974
      Location:629 → 652
      EGF_2; EGF-like domain
      pfam00041
      Location:2044 → 2123
      fn3; Fibronectin type III domain

    8. XM_021083154.1 → XP_020938813.1  tenascin isoform X9

      UniProtKB/TrEMBL
      A0A8D0ZT49
      Conserved Domains (4) summary
      cd00063
      Location:751 → 837
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00147
      Location:2016 → 2225
      Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
      pfam07974
      Location:600 → 623
      EGF_2; EGF-like domain
      pfam00041
      Location:1924 → 2003
      fn3; Fibronectin type III domain

    9. XM_021083143.1 → XP_020938802.1  tenascin isoform X7

      UniProtKB/TrEMBL
      A0A8D0ZT49
      Conserved Domains (4) summary
      cd00063
      Location:780 → 866
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00147
      Location:2045 → 2254
      Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
      pfam07974
      Location:629 → 652
      EGF_2; EGF-like domain
      pfam00041
      Location:1953 → 2032
      fn3; Fibronectin type III domain

    10. XM_021083159.1 → XP_020938818.1  tenascin isoform X10

      UniProtKB/TrEMBL
      A0A8D1IVJ0
      Related
      ENSSSCP00000043968.3, ENSSSCT00000037550.3
      Conserved Domains (4) summary
      cd00063
      Location:780 → 866
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00147
      Location:1955 → 2164
      Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
      pfam07974
      Location:629 → 652
      EGF_2; EGF-like domain
      pfam00041
      Location:1863 → 1942
      fn3; Fibronectin type III domain

    11. XM_021083140.1 → XP_020938799.1  tenascin isoform X6

      UniProtKB/TrEMBL
      A0A8D0ZSZ7
      Conserved Domains (4) summary
      cd00063
      Location:780 → 866
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00147
      Location:2045 → 2254
      Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
      pfam07974
      Location:629 → 652
      EGF_2; EGF-like domain
      pfam00041
      Location:1953 → 2032
      fn3; Fibronectin type III domain

    12. XM_021083172.1 → XP_020938831.1  tenascin isoform X13

      UniProtKB/TrEMBL
      A0A8D1L6G9
      Related
      ENSSSCP00000022200.4, ENSSSCT00000032138.4
      Conserved Domains (4) summary
      cd00063
      Location:751 → 837
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00147
      Location:1925 → 2134
      Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
      pfam07974
      Location:600 → 623
      EGF_2; EGF-like domain
      pfam00041
      Location:1833 → 1912
      fn3; Fibronectin type III domain

    13. XM_021083182.1 → XP_020938841.1  tenascin isoform X16

      UniProtKB/TrEMBL
      A0A287AVF2
      Related
      ENSSSCP00000047909.2, ENSSSCT00000041382.3
      Conserved Domains (4) summary
      cd00063
      Location:780 → 866
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00147
      Location:1863 → 2072
      Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
      pfam07974
      Location:629 → 652
      EGF_2; EGF-like domain
      pfam00041
      Location:1771 → 1850
      fn3; Fibronectin type III domain

    14. XM_021083166.1 → XP_020938825.1  tenascin isoform X11

      UniProtKB/TrEMBL
      A0A8D1L6G9
      Conserved Domains (4) summary
      cd00063
      Location:780 → 866
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00147
      Location:1954 → 2163
      Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
      pfam07974
      Location:629 → 652
      EGF_2; EGF-like domain
      pfam00041
      Location:1862 → 1941
      fn3; Fibronectin type III domain

    15. XM_021083176.1 → XP_020938835.1  tenascin isoform X14

      UniProtKB/TrEMBL
      A0A8D1J5G6
      Conserved Domains (4) summary
      cd00063
      Location:751 → 837
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00147
      Location:1925 → 2134
      Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
      pfam07974
      Location:600 → 623
      EGF_2; EGF-like domain
      pfam00041
      Location:1833 → 1912
      fn3; Fibronectin type III domain

    16. XM_021083169.1 → XP_020938828.1  tenascin isoform X12

      UniProtKB/TrEMBL
      A0A8D1J5G6
      Conserved Domains (4) summary
      cd00063
      Location:780 → 866
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00147
      Location:1954 → 2163
      Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
      pfam07974
      Location:629 → 652
      EGF_2; EGF-like domain
      pfam00041
      Location:1862 → 1941
      fn3; Fibronectin type III domain

    17. XM_021083179.1 → XP_020938838.1  tenascin isoform X15

      UniProtKB/TrEMBL
      A0A8D1ITS2
      Conserved Domains (4) summary
      cd00063
      Location:780 → 866
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00147
      Location:1863 → 2072
      Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
      pfam07974
      Location:629 → 652
      EGF_2; EGF-like domain
      pfam00041
      Location:1771 → 1850
      fn3; Fibronectin type III domain

    18. XM_021083188.1 → XP_020938847.1  tenascin isoform X17

      UniProtKB/TrEMBL
      A0A8D1J3Q8
      Conserved Domains (4) summary
      cd00063
      Location:780 → 866
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00147
      Location:1590 → 1799
      Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
      pfam07974
      Location:629 → 652
      EGF_2; EGF-like domain
      pfam00041
      Location:1498 → 1577
      fn3; Fibronectin type III domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q29116.1 GenPept UniProtKB/Swiss-Prot:Q29116

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