HP haptoglobin [Sus scrofa (pig)] - Gene

Summary

Gene symbol: HP
Gene description: haptoglobin
See related: Ensembl:ENSSSCG00000002749
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression: Biased expression in liver (RPKM 10246.7) and mixtures (RPKM 3844.5) See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	6	NC_010448.4 (14980382..14985245)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	6	NC_010448.3 (14643378..14648241)

Chromosome 6 - NC_010448.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Evidence of haptoglobin in the porcine female genital tract during oestrous cycle and its effect on in vitro embryo production.
Title: Evidence of haptoglobin in the porcine female genital tract during oestrous cycle and its effect on in vitro embryo production.
crystal structure of the dimeric porcine haptoglobin-haemoglobin complex determined at 2.9 A resolution
Title: Structure of the haptoglobin-haemoglobin complex.
Presence of haptoglobin alpha 1S subunit is a reponse to respiratory syndrome virus infection.
Title: Presence of free haptoglobin alpha 1S-subunit in acute porcine reproductive and respiratory syndrome virus infection.
The haptoglobin was down-regulated with SNPs
Title: Detection of SNPs in porcine haptoglobin and apolipoprotein genes.
This study suggested closer links between the release of haptoglobin, Pig-MAP and monocytes compared to the release of AGP, SAA and transthyretin.
Title: The association between plasma levels of acute phase proteins, haptoglobin, alpha-1 acid glycoprotein (AGP), pig-MAP, transthyretin and serum amyloid A (SAA) in Large White and Meishan pigs.
haptoglobin has a role in oxidative status in piglets undergoing weaning-induced stress
Title: The acute phase protein haptoglobin and its relation to oxidative status in piglets undergoing weaning-induced stress.
This protein is elevated in porcine postweaning multisystemic wasting syndrome.
Title: Haptoglobin and pig-major acute protein are increased in pigs with postweaning multisystemic wasting syndrome (PMWS).

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables hemoglobin binding	IEA Inferred from Electronic Annotation more info	PubMed
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in acute inflammatory response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: haptoglobin

Names: haptoglobin alpha 1S; zonulin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_214000.2 → NP_999165.1 haptoglobin precursor

See identical proteins and their annotated locations for NP_999165.1

Status: VALIDATED

Source sequence(s)

AK232478, CJ004687

UniProtKB/Swiss-Prot

Q8SPS7

UniProtKB/TrEMBL

B3GQZ2

Related

ENSSSCP00000002967.3, ENSSSCT00000003046.4

Conserved Domains (2) summary

cd00033
Location:33 → 87

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

cd00190
Location:103 → 343

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

NC_010448.4 Reference Sscrofa11.1 Primary Assembly

Range

14980382..14985245

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005664359.2 → XP_005664416.1 haptoglobin isoform X1

UniProtKB/TrEMBL

A0A8D0LMR0

Conserved Domains (2) summary

smart00020
Location:56 → 294

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:57 → 297

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...