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    COL12A1 collagen type XII alpha 1 chain [ Gallus gallus (chicken) ]

    Gene ID: 395875, updated on 10-Oct-2024

    Summary

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    Official Symbol
    COL12A1provided by CGNC
    Official Full Name
    collagen type XII alpha 1 chainprovided by CGNC
    Primary source
    CGNC:49526
    See related
    Ensembl:ENSGALG00010004096
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See COL12A1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    70
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 3 NC_052534.1 (80494177..80599905)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 3 NC_052575.1 (80285904..80391612)

    Chromosome 3 - NC_052534.1Genomic Context describing neighboring genes Neighboring gene uncharacterized protein FLJ37310-like Neighboring gene transmembrane protein 30A Neighboring gene cytochrome c oxidase subunit 7A2 Neighboring gene CD109 molecule Neighboring gene uncharacterized LOC124417884

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Large and small splice variants of collagen XII: differential expression and ligand binding. Koch M, et al. J Cell Biol, 1995 Aug. PMID 7642694, Free PMC Article
    2. Type XII collagen: distinct extracellular matrix component discovered by cDNA cloning. Gordon MK, et al. Proc Natl Acad Sci U S A, 1987 Sep. PMID 3476925, Free PMC Article
    3. Type XII collagen. A large multidomain molecule with partial homology to type IX collagen. Gordon MK, et al. J Biol Chem, 1989 Nov 25. PMID 2584192
    4. The complete primary structure of type XII collagen shows a chimeric molecule with reiterated fibronectin type III motifs, von Willebrand factor A motifs, a domain homologous to a noncollagenous region of type IX collagen, and short collagenous domains with an Arg-Gly-Asp site. Yamagata M, et al. J Cell Biol, 1991 Oct. PMID 1918137, Free PMC Article
    5. The two splice variants of collagen XII share a common 5' end. Trueb J, et al. Biochim Biophys Acta, 1992 Nov 15. PMID 1420368

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Collagen XII interacts with avian tenascin-X through its NC3 domain
      Title: Collagen XII interacts with avian tenascin-X through its NC3 domain.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    collagen alpha-1(XII) chain
    Names
    collagen XII
    collagen, type XII, alpha 1
    fibrochimerin
    type XII collagen

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_205021.4 → NP_990352.2  collagen alpha-1(XII) chain precursor

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000065
      UniProtKB/Swiss-Prot
      P13944, Q04509
      UniProtKB/TrEMBL
      A0A1L1RPW4
      Related
      ENSGALP00010005636.1, ENSGALT00010009597.1
      Conserved Domains (5) summary
      smart00210
      Location:2522 → 2714
      TSPN; Thrombospondin N-terminal -like domains
      cd00063
      Location:2120 → 2199
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd01482
      Location:1196 → 1359
      vWA_collagen_alphaI-XII-like; Collagen: The extracellular matrix represents a complex alloy of variable members of diverse protein families defining structural integrity and various physiological functions. The most abundant family is the collagens with more than 20 different ...
      pfam00041
      Location:723 → 800
      fn3; Fibronectin type III domain
      pfam01391
      Location:2763 → 2825
      Collagen; Collagen triple helix repeat (20 copies)

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052534.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      80494177..80599905
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040696832.2 → XP_040552766.1  collagen alpha-1(XII) chain isoform X1

      UniProtKB/Swiss-Prot
      P13944, Q04509
      UniProtKB/TrEMBL
      A0A1L1RPW4
      Related
      ENSGALP00010005629.1, ENSGALT00010009577.1
      Conserved Domains (5) summary
      smart00210
      Location:2522 → 2714
      TSPN; Thrombospondin N-terminal -like domains
      cd00063
      Location:2120 → 2199
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd01482
      Location:1196 → 1359
      vWA_collagen_alphaI-XII-like; Collagen: The extracellular matrix represents a complex alloy of variable members of diverse protein families defining structural integrity and various physiological functions. The most abundant family is the collagens with more than 20 different ...
      pfam00041
      Location:723 → 800
      fn3; Fibronectin type III domain
      pfam01391
      Location:2763 → 2825
      Collagen; Collagen triple helix repeat (20 copies)

    2. XM_015284739.4 → XP_015140225.1  collagen alpha-1(XII) chain isoform X1

      UniProtKB/Swiss-Prot
      P13944, Q04509
      UniProtKB/TrEMBL
      A0A1L1RPW4
      Conserved Domains (5) summary
      smart00210
      Location:2522 → 2714
      TSPN; Thrombospondin N-terminal -like domains
      cd00063
      Location:2120 → 2199
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd01482
      Location:1196 → 1359
      vWA_collagen_alphaI-XII-like; Collagen: The extracellular matrix represents a complex alloy of variable members of diverse protein families defining structural integrity and various physiological functions. The most abundant family is the collagens with more than 20 different ...
      pfam00041
      Location:723 → 800
      fn3; Fibronectin type III domain
      pfam01391
      Location:2763 → 2825
      Collagen; Collagen triple helix repeat (20 copies)

    3. XM_046938509.1 → XP_046794465.1  collagen alpha-1(XII) chain isoform X5

    4. XM_046938506.1 → XP_046794462.1  collagen alpha-1(XII) chain isoform X1

      UniProtKB/TrEMBL
      A0A1L1RPW4

    5. XM_046938508.1 → XP_046794464.1  collagen alpha-1(XII) chain isoform X1

      UniProtKB/TrEMBL
      A0A1L1RPW4

    6. XM_046938511.1 → XP_046794467.1  collagen alpha-1(XII) chain isoform X5

    7. XM_046938507.1 → XP_046794463.1  collagen alpha-1(XII) chain isoform X1

      UniProtKB/TrEMBL
      A0A1L1RPW4

    8. XM_015284742.4 → XP_015140228.1  collagen alpha-1(XII) chain isoform X3

      UniProtKB/Swiss-Prot
      P13944, Q04509
      UniProtKB/TrEMBL
      A0A1D5P8I8
      Related
      ENSGALP00010005635.1, ENSGALT00010009589.1
      Conserved Domains (5) summary
      pfam01391
      Location:2767 → 2893
      Collagen; Collagen triple helix repeat (20 copies)
      smart00210
      Location:2522 → 2714
      TSPN; Thrombospondin N-terminal -like domains
      cd00063
      Location:2120 → 2199
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd01482
      Location:1196 → 1359
      vWA_collagen_alphaI-XII-like; Collagen: The extracellular matrix represents a complex alloy of variable members of diverse protein families defining structural integrity and various physiological functions. The most abundant family is the collagens with more than 20 different ...
      pfam00041
      Location:723 → 800
      fn3; Fibronectin type III domain

    9. XM_015284744.4 → XP_015140230.1  collagen alpha-1(XII) chain isoform X5

      Conserved Domains (5) summary
      pfam01391
      Location:1605 → 1731
      Collagen; Collagen triple helix repeat (20 copies)
      smart00210
      Location:1360 → 1552
      TSPN; Thrombospondin N-terminal -like domains
      cd00063
      Location:958 → 1037
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd01482
      Location:34 → 197
      vWA_collagen_alphaI-XII-like; Collagen: The extracellular matrix represents a complex alloy of variable members of diverse protein families defining structural integrity and various physiological functions. The most abundant family is the collagens with more than 20 different ...
      pfam00041
      Location:222 → 301
      fn3; Fibronectin type III domain

    10. XM_015284743.3 → XP_015140229.1  collagen alpha-1(XII) chain isoform X4

      UniProtKB/Swiss-Prot
      P13944, Q04509
      UniProtKB/TrEMBL
      F1NX22
      Related
      ENSGALP00010005631.1, ENSGALT00010009585.1
      Conserved Domains (5) summary
      pfam01391
      Location:2767 → 2893
      Collagen; Collagen triple helix repeat (20 copies)
      smart00210
      Location:2522 → 2714
      TSPN; Thrombospondin N-terminal -like domains
      cd00063
      Location:2120 → 2199
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd01482
      Location:1196 → 1359
      vWA_collagen_alphaI-XII-like; Collagen: The extracellular matrix represents a complex alloy of variable members of diverse protein families defining structural integrity and various physiological functions. The most abundant family is the collagens with more than 20 different ...
      pfam00041
      Location:723 → 800
      fn3; Fibronectin type III domain

    11. XM_040696833.2 → XP_040552767.1  collagen alpha-1(XII) chain isoform X2

      UniProtKB/TrEMBL
      A0A8V0XG00
      Conserved Domains (4) summary
      smart00060
      Location:1432 → 1501
      FN3; Fibronectin type 3 domain
      smart00210
      Location:2480 → 2672
      TSPN; Thrombospondin N-terminal -like domains
      cd00063
      Location:681 → 758
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd01482
      Location:1154 → 1317
      vWA_collagen_alphaI-XII-like; Collagen: The extracellular matrix represents a complex alloy of variable members of diverse protein families defining structural integrity and various physiological functions. The most abundant family is the collagens with more than 20 different ...

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052575.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      80285904..80391612
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046913161.1 → XP_046769117.1  collagen alpha-1(XII) chain isoform X1

      UniProtKB/TrEMBL
      A0A1L1RPW4

    2. XM_046913162.1 → XP_046769118.1  collagen alpha-1(XII) chain isoform X1

      UniProtKB/TrEMBL
      A0A1L1RPW4

    3. XM_046913169.1 → XP_046769125.1  collagen alpha-1(XII) chain isoform X5

    4. XM_046913160.1 → XP_046769116.1  collagen alpha-1(XII) chain isoform X1

      UniProtKB/TrEMBL
      A0A1L1RPW4

    5. XM_046913164.1 → XP_046769120.1  collagen alpha-1(XII) chain isoform X1

      UniProtKB/TrEMBL
      A0A1L1RPW4

    6. XM_046913170.1 → XP_046769126.1  collagen alpha-1(XII) chain isoform X5

    7. XM_046913163.1 → XP_046769119.1  collagen alpha-1(XII) chain isoform X1

      UniProtKB/TrEMBL
      A0A1L1RPW4

    8. XM_046913166.1 → XP_046769122.1  collagen alpha-1(XII) chain isoform X3

      UniProtKB/TrEMBL
      A0A1D5P8I8

    9. XM_046913168.1 → XP_046769124.1  collagen alpha-1(XII) chain isoform X5

    10. XM_046913167.1 → XP_046769123.1  collagen alpha-1(XII) chain isoform X4

      UniProtKB/TrEMBL
      F1NX22

    11. XM_046913165.1 → XP_046769121.1  collagen alpha-1(XII) chain isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P13944.3 GenPept UniProtKB/Swiss-Prot:P13944

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