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    STAR steroidogenic acute regulatory protein [ Gallus gallus (chicken) ]

    Gene ID: 395421, updated on 17-Aug-2024

    Summary

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    Symbol
    STARprovided by CGNC
    Full Name
    steroidogenic acute regulatory proteinprovided by CGNC
    Primary source
    CGNC:2354
    See related
    Ensembl:ENSGALG00010017783
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See STAR in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 22 NC_052553.1 (2436633..2439887, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 22 NC_052594.1 (2483973..2487227, complement)

    Chromosome 22 - NC_052553.1Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 4E binding protein 1 Neighboring gene nodal growth differentiation factor Neighboring gene ASH2 like histone lysine methyltransferase complex subunit Neighboring gene LSM1 homolog, mRNA degradation associated Neighboring gene uncharacterized LOC121107412 Neighboring gene BCL2 associated athanogene 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on secretion of steroids and STAR, HSD3B and CYP19A1 mRNA expression in chicken ovarian follicles. Sechman A, et al. Toxicol Lett, 2014 Mar 3. PMID 24398026
    2. Effect of 3,3',5-triiodothyronine and 3,5-diiodothyronine on progesterone production, cAMP synthesis, and mRNA expression of STAR, CYP11A1, and HSD3B genes in granulosa layer of chicken preovulatory follicles. Sechman A, et al. Domest Anim Endocrinol, 2011 Oct. PMID 21798688
    3. Testosterone stimulates progesterone production and STAR, P450 cholesterol side-chain cleavage and LH receptor mRNAs expression in hen (Gallus domesticus) granulosa cells. Rangel PL, et al. Reproduction, 2009 Dec. PMID 19710202
    4. Conservation of steroidogenic acute regulatory (StAR) protein structure and expression in vertebrates. Bauer MP, et al. Mol Cell Endocrinol, 2000 Oct 25. PMID 11064158
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TCDD inhibits steroidogenesis by influencing STAR, HSD3B and CYP19A1 mRNA expression.
      Title: Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on secretion of steroids and STAR, HSD3B and CYP19A1 mRNA expression in chicken ovarian follicles.
    2. This study showed that the effects of iodothyronines depend on follicle maturation and are associated with modulation of cAMP synthesis and STAR, CYP11A1, and HSD3B mRNA expression.
      Title: Effect of 3,3',5-triiodothyronine and 3,5-diiodothyronine on progesterone production, cAMP synthesis, and mRNA expression of STAR, CYP11A1, and HSD3B genes in granulosa layer of chicken preovulatory follicles.
    3. Testosterone (10 or 100 ng/ml) increased STAR, P450scc, and LHCGR mRNAs, when added to 3 h cultures of F1 granulosa cells.
      Title: Testosterone stimulates progesterone production and STAR, P450 cholesterol side-chain cleavage and LH receptor mRNAs expression in hen (Gallus domesticus) granulosa cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cholesterol binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables cholesterol transfer activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular cholesterol transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of steroid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in steroid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial intermembrane space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    steroidogenic acute regulatory protein, mitochondrial
    Names
    START domain-containing protein 1
    stARD1
    steroidogenic acute regulator

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_204686.3 → NP_990017.1  steroidogenic acute regulatory protein, mitochondrial precursor

      See identical proteins and their annotated locations for NP_990017.1

      Status: PROVISIONAL

      Source sequence(s)
      JAENSK010000332
      UniProtKB/Swiss-Prot
      Q9DG09
      UniProtKB/TrEMBL
      A0A8V0Z306
      Related
      ENSGALP00010025464.1, ENSGALT00010042974.1
      Conserved Domains (1) summary
      cd08905
      Location:70 → 278
      START_STARD1-like; Cholesterol-binding START domain of mammalian STARD1 and related proteins

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052553.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      2436633..2439887 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052594.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      2483973..2487227 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DG09.1 GenPept UniProtKB/Swiss-Prot:Q9DG09

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.