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    tpm1 tropomyosin 1 (alpha) [ Danio rerio (zebrafish) ]

    Gene ID: 393908, updated on 14-Nov-2024

    Summary

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    Official Symbol
    tpm1provided by ZNC
    Official Full Name
    tropomyosin 1 (alpha)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-854
    See related
    Ensembl:ENSDARG00000087402 AllianceGenome:ZFIN:ZDB-GENE-040426-854
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    Tm1; TPM1-1; zgc:55951; zgc:77009; zgc:171719
    Summary
    Predicted to enable actin filament binding activity. Predicted to be involved in actin filament organization and muscle contraction. Predicted to be active in actin filament. Is expressed in adaxial cell; heart; and musculature system. Human ortholog(s) of this gene implicated in congenital myopathy 4A; dilated cardiomyopathy 1Y; familial hypertrophic cardiomyopathy; hypertrophic cardiomyopathy 3; and nemaline myopathy 1. Orthologous to several human genes including TPM1 (tropomyosin 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See tpm1 in Genome Data Viewer
    Location:
    chromosome: 25
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (33192796..33250323)
    105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (32707311..32764896)

    Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene C2 calcium dependent domain containing 4A Neighboring gene talin 2b Neighboring gene microRNA 190 Neighboring gene proepiregulin-like Neighboring gene lactamase, beta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Identification, characterization, and expression of sarcomeric tropomyosin isoforms in zebrafish. Dube DK, et al. Cytoskeleton (Hoboken), 2017 Mar. PMID 27998020, Free PMC Article
    2. A role for DNA methylation in gastrulation and somite patterning. Martin CC, et al. Dev Biol, 1999 Feb 15. PMID 9986732
    3. ErbB4 tyrosine kinase inhibition impairs neuromuscular development in zebrafish embryos. Paatero I, et al. Mol Biol Cell, 2019 Jan 15. PMID 30462579, Free PMC Article
    4. Ibuprofen and diclofenac impair the cardiovascular development of zebrafish (Danio rerio) at low concentrations. Zhang K, et al. Environ Pollut, 2020 Mar. PMID 31838392
    5. Differential gene expression associated with dietary methylmercury (MeHg) exposure in rainbow trout (Oncorhynchus mykiss) and zebrafish (Danio rerio). Liu Q, et al. Ecotoxicology, 2013 May. PMID 23529582, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC55951, MGC171719

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cardiac muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tropomyosin alpha-1 chain
    Names
    tropomyosin 1-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001102629.2 → NP_001096099.1  tropomyosin alpha-1 chain isoform 3

      See identical proteins and their annotated locations for NP_001096099.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate downstream promoter and has additional differences in the coding region compared to variant 1. The resulting protein (isoform 3) is shorter and has a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      CABZ01046954, CABZ01046957, EH542593
      UniProtKB/TrEMBL
      A0A8M1NDZ4, A7E2K1
      Related
      ENSDARP00000108795.1, ENSDART00000131098.3
      Conserved Domains (2) summary
      pfam00261
      Location:11 → 245
      Tropomyosin; Tropomyosin
      pfam07851
      Location:143 → 240
      TMPIT; TMPIT-like protein

    2. NM_001293168.1 → NP_001280097.1  tropomyosin alpha-1 chain isoform 2

      See identical proteins and their annotated locations for NP_001280097.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR compare to variant 1. The resulting protein (isoform 2) has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      EH433771, EH462147, EH467172
      UniProtKB/TrEMBL
      A0A8M1P687, F6NVA3, Q7ZVK9
      Related
      ENSDARP00000111203.3, ENSDART00000125892.3
      Conserved Domains (1) summary
      pfam00261
      Location:48 → 282
      Tropomyosin

    3. NM_200934.3 → NP_957228.2  tropomyosin alpha-1 chain isoform 1

      See identical proteins and their annotated locations for NP_957228.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
      Source sequence(s)
      CABZ01046954, CABZ01046957, CABZ01046958, CABZ01046959
      UniProtKB/TrEMBL
      A0A8M1PFA6, F6P435, Q6NYQ0
      Related
      ENSDARP00000112368.3, ENSDART00000121680.3
      Conserved Domains (2) summary
      pfam00261
      Location:48 → 282
      Tropomyosin; Tropomyosin
      pfam07851
      Location:180 → 277
      TMPIT; TMPIT-like protein

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007136.7 Reference GRCz11 Primary Assembly

      Range
      33192796..33250323
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068217345.1 → XP_068073446.1  tropomyosin alpha-1 chain isoform X16

    2. XM_068217344.1 → XP_068073445.1  tropomyosin alpha-1 chain isoform X10

    3. XM_009298155.4 → XP_009296430.1  tropomyosin alpha-1 chain isoform X6

      UniProtKB/TrEMBL
      A0A8M3APV7
      Conserved Domains (2) summary
      pfam00261
      Location:48 → 282
      Tropomyosin; Tropomyosin
      pfam07851
      Location:180 → 277
      TMPIT; TMPIT-like protein

    4. XM_068217342.1 → XP_068073443.1  tropomyosin alpha-1 chain isoform X8

    5. XM_068217343.1 → XP_068073444.1  tropomyosin alpha-1 chain isoform X9

    6. XM_005174377.5 → XP_005174434.1  tropomyosin alpha-1 chain isoform X4

      UniProtKB/TrEMBL
      A0A8M2BLM4
      Conserved Domains (2) summary
      pfam00261
      Location:48 → 282
      Tropomyosin; Tropomyosin
      pfam07851
      Location:180 → 277
      TMPIT; TMPIT-like protein

    7. XM_017354064.3 → XP_017209553.1  tropomyosin alpha-1 chain isoform X7

      UniProtKB/TrEMBL
      A0A8M6Z4C1
      Conserved Domains (1) summary
      pfam00261
      Location:48 → 280
      Tropomyosin

    8. XM_005174371.5 → XP_005174428.1  tropomyosin alpha-1 chain isoform X2

      UniProtKB/TrEMBL
      A0A8M2BLW8
      Conserved Domains (1) summary
      pfam00261
      Location:48 → 282
      Tropomyosin

    9. XM_005174375.5 → XP_005174432.2  tropomyosin alpha-1 chain isoform X1

      UniProtKB/TrEMBL
      A0A1L6UW63, E7FBZ3
      Related
      ENSDARP00000002483.9, ENSDART00000014851.9
      Conserved Domains (1) summary
      pfam00261
      Location:48 → 282
      Tropomyosin

    10. XM_021470465.2 → XP_021326140.1  tropomyosin alpha-1 chain isoform X3

      UniProtKB/TrEMBL
      A0A8M9PYA8
      Conserved Domains (1) summary
      pfam00261
      Location:48 → 282
      Tropomyosin

    11. XM_068217346.1 → XP_068073447.1  tropomyosin alpha-1 chain isoform X17

    12. XM_068217347.1 → XP_068073448.1  tropomyosin alpha-1 chain isoform X18

    13. XM_068217341.1 → XP_068073442.1  tropomyosin alpha-1 chain isoform X5

    14. XM_021470467.2 → XP_021326142.1  tropomyosin alpha-1 chain isoform X15

      UniProtKB/TrEMBL
      A0A8M9P6D8
      Conserved Domains (1) summary
      pfam00261
      Location:11 → 243
      Tropomyosin

    15. XM_005174385.5 → XP_005174442.1  tropomyosin alpha-1 chain isoform X14

      UniProtKB/TrEMBL
      A0A8M2BLW9
      Conserved Domains (1) summary
      pfam00261
      Location:11 → 243
      Tropomyosin; Tropomyosin

    16. XM_009298156.4 → XP_009296431.1  tropomyosin alpha-1 chain isoform X12

      UniProtKB/TrEMBL
      A0A8M3AZU4
      Conserved Domains (2) summary
      pfam00261
      Location:11 → 245
      Tropomyosin; Tropomyosin
      pfam07851
      Location:143 → 240
      TMPIT; TMPIT-like protein

    17. XM_021470466.2 → XP_021326141.1  tropomyosin alpha-1 chain isoform X13

      UniProtKB/TrEMBL
      A0A8M9PUV7
      Conserved Domains (1) summary
      pfam00261
      Location:11 → 245
      Tropomyosin

    18. XM_005174381.5 → XP_005174438.1  tropomyosin alpha-1 chain isoform X11

      UniProtKB/TrEMBL
      A0A2R8RQ88, A0A8M2BLN3
      Related
      ENSDARP00000150453.1, ENSDART00000192378.1
      Conserved Domains (2) summary
      pfam00261
      Location:11 → 245
      Tropomyosin; Tropomyosin
      pfam07851
      Location:143 → 237
      TMPIT; TMPIT-like protein
    Nucleotide Protein Strain
    Heading Accession and Version

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