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    gna11.S guanine nucleotide binding protein (G protein), alpha 11 (Gq class) S homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 380535, updated on 4-Nov-2024

    Summary

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    Official Symbol
    gna11.S
    Official Full Name
    guanine nucleotide binding protein (G protein), alpha 11 (Gq class) S homeolog
    Primary source
    Xenbase:XB-GENE-944503
    Locus tag
    XELAEV_18001137mg
    See related
    EnsemblRapid:ENSXLAG00005026227 AllianceGenome:Xenbase:XB-GENE-944503
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    gna11
    Summary
    Predicted to enable several functions, including G-protein beta/gamma-subunit complex binding activity; GTP binding activity; and GTPase activity. Predicted to act upstream of or within action potential; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; and phospholipase C-activating dopamine receptor signaling pathway. Predicted to be located in membrane and photoreceptor outer segment. Predicted to be part of heterotrimeric G-protein complex. Is expressed in nervous system and urinary system. Human ortholog(s) of this gene implicated in autosomal dominant hypocalcemia 2 and familial hypocalciuric hypercalcemia 2. Orthologous to human GNA11 (G protein subunit alpha 11). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See gna11.S in Genome Data Viewer
    Location:
    chromosome: 1S
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 1S NC_054372.1 (103910754..103973131)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) Unplaced Scaffold NW_016694812.1 (992229..1024562, complement)

    Chromosome 1S - NC_054372.1Genomic Context describing neighboring genes Neighboring gene transducin like enhancer of split 1 S homeolog Neighboring gene TLE family member 5, transcriptional modulator homeolog Neighboring gene lamina-associated polypeptide 2-like Neighboring gene protein kinase C delta type-like Neighboring gene protein kinase C delta type-like Neighboring gene protein kinase C delta type-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC53492

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables G-protein beta/gamma-subunit complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within action potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within adenylate cyclase-modulating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phospholipase C-activating dopamine receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of heterotrimeric G-protein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in photoreceptor outer segment ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    guanine nucleotide binding protein (G protein), alpha 11 (Gq class) S homeolog
    Names
    guanine nucleotide binding protein, alpha 11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001087372.1 → NP_001080841.1  guanine nucleotide binding protein (G protein), alpha 11 (Gq class) S homeolog

      See identical proteins and their annotated locations for NP_001080841.1

      Status: PROVISIONAL

      Source sequence(s)
      BC042284
      UniProtKB/TrEMBL
      Q8AVH0
      Related
      ENSXLAP00005078041.1, ENSXLAT00005079629.1
      Conserved Domains (1) summary
      cd00066
      Location:40 → 353
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054372.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      103910754..103973131
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_041573344.1 → XP_041429278.1  guanine nucleotide binding protein (G protein), alpha 11 (Gq class) S homeolog isoform X1

      UniProtKB/TrEMBL
      Q8AVH0
      Conserved Domains (1) summary
      cd00066
      Location:40 → 353
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

    2. XM_018239814.2 → XP_018095303.1  guanine nucleotide binding protein (G protein), alpha 11 (Gq class) S homeolog isoform X2

      UniProtKB/TrEMBL
      A0A8J0U288, A0A974I115
      Related
      ENSXLAP00005077952.1, ENSXLAT00005079543.1
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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