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    cbfa2t2.L CBFA2/RUNX1 translocation partner 2 L homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 379213, updated on 17-Aug-2024

    Summary

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    Official Symbol
    cbfa2t2.L
    Official Full Name
    CBFA2/RUNX1 translocation partner 2 L homeolog
    Primary source
    Xenbase:XB-GENE-950038
    Locus tag
    XELAEV_18043980mg
    See related
    EnsemblRapid:ENSXLAG00005023186
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    MTGR1; XETOR; cbfa2t2; cbfa2t2-a
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    Genomic context

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    See cbfa2t2.L in Genome Data Viewer
    Location:
    chromosome: 9_10L
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 9_10L NC_054387.1 (45255805..45281233)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 9_10L NC_030740.1 (34934381..34959921)

    Chromosome 9_10L - NC_054387.1Genomic Context describing neighboring genes Neighboring gene traf2 and NCK-interacting protein kinase-like Neighboring gene phosphatidylinositol glycan anchor biosynthesis class T L homeolog Neighboring gene interleukin-17D Neighboring gene N-terminal EF-hand calcium binding protein 3 L homeolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. XETOR regulates the size of the proneural domain during primary neurogenesis in Xenopus laevis. Cao Y, et al. Mech Dev, 2002 Nov. PMID 12385752
    2. The expression and function of MTG/ETO family proteins during neurogenesis. Koyano-Nakagawa N, et al. Dev Biol, 2005 Feb 1. PMID 15649458
    3. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC53378

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription corepressor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of neurogenesis IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of neuron projection development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein CBFA2T2
    Names
    MTG8-like protein
    MTG8-related protein 1
    a subunit 2; translocated to, 2
    core-binding factor, runt domain, alpha subunit 2; translocated to, 2 L homeolog
    expressed during neurogenesis

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001086057.1 → NP_001079526.1  protein CBFA2T2

      See identical proteins and their annotated locations for NP_001079526.1

      Status: PROVISIONAL

      Source sequence(s)
      BC044006
      UniProtKB/TrEMBL
      Q5IJ69, Q7ZY26
      Related
      ENSXLAP00005068650.1, ENSXLAT00005070184.1
      Conserved Domains (4) summary
      pfam01753
      Location:497 → 533
      zf-MYND; MYND finger
      pfam07531
      Location:104 → 190
      TAFH; NHR1 homology to TAF
      pfam08788
      Location:322 → 388
      NHR2; NHR2 domain like
      cl23750
      Location:423 → 478
      vATP-synt_E; ATP synthase (E/31 kDa) subunit

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054387.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      45255805..45281233
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_041575479.1 → XP_041431413.1  protein CBFA2T2 isoform X2

      UniProtKB/TrEMBL
      A0A8J1LPB5, A0A974BXW6, Q5IJ69
      Related
      ENSXLAP00005068728.1, ENSXLAT00005070262.1
      Conserved Domains (3) summary
      smart00549
      Location:56 → 146
      TAFH; TAF homology
      COG1390
      Location:375 → 448
      NtpE; Archaeal/vacuolar-type H+-ATPase subunit E/Vma4 [Energy production and conversion]
      pfam08788
      Location:274 → 340
      NHR2; NHR2 domain like

    2. XM_041575478.1 → XP_041431412.1  protein CBFA2T2 isoform X1

      UniProtKB/TrEMBL
      A0A8J1LPE2, A0A974BXW6
      Related
      ENSXLAP00005068690.1, ENSXLAT00005070224.1
      Conserved Domains (3) summary
      smart00549
      Location:120 → 210
      TAFH; TAF homology
      COG1390
      Location:439 → 512
      NtpE; Archaeal/vacuolar-type H+-ATPase subunit E/Vma4 [Energy production and conversion]
      pfam08788
      Location:338 → 404
      NHR2; NHR2 domain like
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9IAB2.2 GenPept UniProtKB/Swiss-Prot:Q9IAB2

    Gene LinkOut

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