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    gad1.L glutamate decarboxylase 1 L homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 378551, updated on 4-Nov-2024

    Summary

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    Official Symbol
    gad1.L
    Official Full Name
    glutamate decarboxylase 1 L homeolog
    Primary source
    Xenbase:XB-GENE-1011702
    Locus tag
    XELAEV_18044679mg
    See related
    EnsemblRapid:ENSXLAG00005033740 AllianceGenome:Xenbase:XB-GENE-1011702
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    GAD; gad1; cpsq1; gad67; gad1-A; gad1.1; gad1.1.L
    Summary
    Predicted to enable glutamate decarboxylase activity and pyridoxal phosphate binding activity. Predicted to act upstream of or within gamma-aminobutyric acid biosynthetic process. Predicted to be located in cytoplasm and presynaptic active zone. Is expressed in ectoderm; nervous system; sensory system; and visual system. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; amphetamine abuse; developmental and epileptic encephalopathy 89; drug psychosis; and heroin dependence. Orthologous to human GAD1 (glutamate decarboxylase 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See gad1.L in Genome Data Viewer
    Location:
    chromosome: 9_10L
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 9_10L NC_054387.1 (75639346..75679737)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 9_10L NC_030740.1 (65135678..65175545)

    Chromosome 9_10L - NC_054387.1Genomic Context describing neighboring genes Neighboring gene myosin 3b L homeolog Neighboring gene Sp5 transcription factor L homeolog Neighboring gene golgi reassembly stacking protein 2 L homeolog Neighboring gene izumo sperm-egg fusion protein 3-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables carboxy-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutamate decarboxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within carboxylic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within gamma-aminobutyric acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in presynaptic active zone IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glutamate decarboxylase 1 L homeolog; glutamate decarboxylase 1
    Names
    glutamate decarboxylase 1 (brain, 67kDa), gene 1
    XP_018089468.2
    XP_041432056.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054387.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      75639346..75679737
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_018233979.2 → XP_018089468.2  glutamate decarboxylase 1 isoform X1

      UniProtKB/TrEMBL
      A0A8J0TQD9, A0A974BZG4, B7ZRR4
      Related
      ENSXLAP00005101466.1, ENSXLAT00005103443.1
      Conserved Domains (1) summary
      cd06450
      Location:183 → 586
      DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...

    2. XM_041576122.1 → XP_041432056.1  glutamate decarboxylase 1 isoform X2

      UniProtKB/TrEMBL
      A0A8J1LSK2, A0A974BZG4, B7ZRR4
      Related
      ENSXLAP00005101249.1, ENSXLAT00005103221.1
      Conserved Domains (1) summary
      cd06450
      Location:153 → 556
      DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001085801.1: Suppressed sequence

      Description
      NM_001085801.1: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version

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