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    BXLF2 envelope glycoprotein H [ Human gammaherpesvirus 4 (Epstein-Barr virus) ]

    Gene ID: 3783742, updated on 20-Nov-2023

    Summary

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    Gene symbol
    BXLF2
    Gene description
    envelope glycoprotein H
    Locus tag
    HHV4_BXLF2
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Human gammaherpesvirus 4 (strain: B95-8, strain: Raji, type: 1, common: Epstein-Barr virus, acronym: EBV, acronym: HHV-4, nat-host: Homo sapiens)
    Lineage
    Viruses; Herpesvirales; Herpesviridae; Gammaherpesvirinae; Lymphocryptovirus
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    Genomic context

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    Sequence:
    NC_007605.1 (128608..131021, complement)

    NC_007605.1Genomic Context describing neighboring genes Neighboring gene envelope glycoprotein 150 Neighboring gene envelope glycoprotein 48 Neighboring gene capsid triplex subunit 2 Neighboring gene major capsid protein Neighboring gene protein UL87 Neighboring gene tegument protein UL88 Neighboring gene thymidine kinase Neighboring gene nuclear protein UL24 Neighboring gene DNA packaging tegument protein UL25 Neighboring gene protein UL79 Neighboring gene capsid maturation protease Neighboring gene capsid scaffold protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_007605.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Epstein-Barr virus glycoprotein gH/gL antibodies complement IgA-viral capsid antigen for diagnosis of nasopharyngeal carcinoma. Li RC, et al. Oncotarget, 2016 Mar 29. PMID 27093005, Free PMC Article
    2. Comparative Mutagenesis of Pseudorabies Virus and Epstein-Barr Virus gH Identifies a Structural Determinant within Domain III of gH Required for Surface Expression and Entry Function. Möhl BS, et al. J Virol, 2015 Dec 9. PMID 26656711, Free PMC Article
    3. Crystal structure of the Epstein-Barr virus (EBV) glycoprotein H/glycoprotein L (gH/gL) complex. Matsuura H, et al. Proc Natl Acad Sci U S A, 2010 Dec 28. PMID 21149717, Free PMC Article
    4. Epstein-Barr Virus gH/gL and Kaposi's Sarcoma-Associated Herpesvirus gH/gL Bind to Different Sites on EphA2 To Trigger Fusion. Chen J, et al. J Virol, 2020 Oct 14. PMID 32847853, Free PMC Article
    5. Structural basis for Epstein-Barr virus host cell tropism mediated by gp42 and gHgL entry glycoproteins. Sathiyamoorthy K, et al. Nat Commun, 2016 Dec 8. PMID 27929061, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Epstein-Barr Virus gH/gL and Kaposi's Sarcoma-Associated Herpesvirus gH/gL Bind to Different Sites on EphA2 To Trigger Fusion.
      Title: Epstein-Barr Virus gH/gL and Kaposi's Sarcoma-Associated Herpesvirus gH/gL Bind to Different Sites on EphA2 To Trigger Fusion.
    2. The critical regulator of EBV tropism is the gp42 N-terminal domain, which tethers the HLA-binding domain to gHgL by wrapping around the exterior of three gH domains.
      Title: Structural basis for Epstein-Barr virus host cell tropism mediated by gp42 and gHgL entry glycoproteins.
    3. Findings suggest that EBV gH/gL detection complements viral capsid antigen (VCA) detection in the diagnosis of nasopharyngeal carcinoma (NPC) and aids in the identification of patients with VCA-negative NPC.
      Title: Epstein-Barr virus glycoprotein gH/gL antibodies complement IgA-viral capsid antigen for diagnosis of nasopharyngeal carcinoma.
    4. The present study verified that the conserved disulfide bond and several contacting amino acids in domain-III modulate cell surface expression and thereby contribute to glycoprotein H function.
      Title: Comparative Mutagenesis of Pseudorabies Virus and Epstein-Barr Virus gH Identifies a Structural Determinant within Domain III of gH Required for Surface Expression and Entry Function.
    5. Data show that the gL subunit and N-terminal residues of gH form a globular domain at one end of the structure.
      Title: Crystal structure of the Epstein-Barr virus (EBV) glycoprotein H/glycoprotein L (gH/gL) complex.
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    General gene information

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    regulatory

    • Loc: c128613-128608 regulatory_class = polyA_signal_sequence
    • Loc: c131021-131016 regulatory_class = TATA_box

    General protein information

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    Preferred Names
    envelope glycoprotein H

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_007605.1 Reference assembly

      Range
      128608..131021 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_401700.1 envelope glycoprotein H [Human gammaherpesvirus 4]

      See identical proteins and their annotated locations for YP_401700.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P03231, Q6LBU6, Q777C0
      UniProtKB/TrEMBL
      A0A0C7T4Q0, A0A0C7T7G6, A0A0C7TH35, A0A0C7TL89, A0A0C7TP05, A0A0C7TVV8, A0A2S1MSI3, A0A385J8N2, A0A385J9E1, V5KU72
      Conserved Domains (2) summary
      pfam02489
      Location:32 → 523
      Herpes_glycop_H; Herpesvirus glycoprotein H main domain
      pfam17488
      Location:531 → 672
      Herpes_glycoH_C; Herpesvirus glycoprotein H C-terminal domain
    Nucleotide Protein
    Heading Accession and Version

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