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    Kaz1-ORFB Kaz1-ORFB [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3772691, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Kaz1-ORFBprovided by FlyBase
    Official Full Name
    Kaz1-ORFBprovided by FlyBase
    Primary source
    FLYBASE:FBgn0063923
    Locus tag
    Dmel_CG1220
    See related
    AllianceGenome:FB:FBgn0063923
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1220; CG33045; Dmel\CG1220; Kaz1; ORF B; ORF C; ORF D; ORF E
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Located in extracellular region. Is expressed in several structures, including dorsal pharyngeal muscle cell; embryonic/larval midgut; embryonic/larval midgut primordium; gastric caecum; and larval muscle system. [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
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    Genomic context

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    See Kaz1-ORFB in Genome Data Viewer
    Location:
    61B2-61B2; 3-1 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (216625..218058)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (216625..218058)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene thoc7 Neighboring gene Dis3 like 3'-5' exoribonuclease 2 Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene pyrexia Neighboring gene long non-coding RNA:CR42862 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Drosophila gene encoding multiple splice variants of Kazal-type serine protease inhibitor-like proteins with potential destinations of mitochondria, cytosol and the secretory pathway. Niimi T, et al. Eur J Biochem, 1999 Nov. PMID 10542076
    2. Identifying new players in structural synaptic plasticity through dArc1 interrogation. Xiao C, et al. iScience, 2023 Nov 17. PMID 37876812, Free PMC Article
    3. Development of fly tolerance to consuming a high-protein diet requires physiological, metabolic and transcriptional changes. Yurkevych IS, et al. Biogerontology, 2020 Oct. PMID 32468146
    4. The tobacco phosphatidylethanolamine-binding protein NtFT4 increases the lifespan of Drosophila melanogaster by interacting with the proteostasis network. Känel P, et al. Aging (Albany NY), 2022 Apr 8. PMID 35396341, Free PMC Article
    5. Notch and Ras signaling pathway effector genes expressed in fusion competent and founder cells during Drosophila myogenesis. Artero R, et al. Development, 2003 Dec. PMID 14602676

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Kaz1-ORFB
    Names
    CG1220-PA
    CG1220-PE
    CG1220-PF
    CG1220-PH
    KAZ1 type C1
    KAZ1 type C2
    KAZ1 type C3
    KAZ1 type D
    KAZ1 type E
    KAZ1 type beta
    Kaz1-ORFB-PA
    Kaz1-ORFB-PE
    Kaz1-ORFB-PF
    Kaz1-ORFB-PH

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      216625..218058
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167809.4 → NP_728495.1  Kaz1-ORFB, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728495.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KYD6, Q8IRJ6
      Conserved Domains (1) summary
      cl00097
      Location:69 → 112
      KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

    2. NM_167810.3 → NP_728496.2  Kaz1-ORFB, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728496.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KYD6, Q8IRJ6
      Conserved Domains (1) summary
      cl00097
      Location:69 → 112
      KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

    3. NM_001031920.3 → NP_001027091.1  Kaz1-ORFB, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001027091.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O97042, Q7YZA1
      Conserved Domains (1) summary
      cl00097
      Location:69 → 99
      KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

    4. NM_138169.5 → NP_612013.3  Kaz1-ORFB, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_612013.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KYD6, Q8IRJ6
      Conserved Domains (1) summary
      cl00097
      Location:69 → 112
      KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O97042 O97042
    Q7KYD6 Q7KYD6
    Q7YZA1 Q7YZA1
    Q8IRJ6 Q8IRJ6

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