Adh Alcohol dehydrogenase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Adhprovided by FlyBase
Official Full Name: Alcohol dehydrogenaseprovided by FlyBase
Primary source: FLYBASE:FBgn0000055
Locus tag: Dmel_CG3481
See related: AllianceGenome:FB:FBgn0000055
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: adh; ADH; Adh3; BG:DS01486.8; CG32954; CG3481; dADH; DM-ADH; DmADH; Dmel\CG3481; Dreg-1; Reg-1; T16
Summary: Enables acetaldehyde dehydrogenase (acetylating) activity; alcohol dehydrogenase (NAD+) activity; and protein homodimerization activity. Involved in several processes, including acetaldehyde metabolic process; behavioral response to ethanol; and ethanol oxidation. Located in cytosol. Part of protein-containing complex. Is expressed in several structures, including circulatory system; digestive system; extended germ band embryo; fat body; and reproductive system. Human ortholog(s) of this gene implicated in colon carcinoma and primary hypertrophic osteoarthropathy. Orthologous to human HPGD (15-hydroxyprostaglandin dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 35B3-35B3; 2-50 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (14615552..14618902)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (14615552..14618902)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The effect of a change in environment on the expression of ADH in D. melanogaser larvae is reported.
Title: Phenotypic plasticity facilitates initial colonization of a novel environment.
The authors found no evidence of a temperature-mediated trade-off in the two major Adh variants, named Fast and Slow: The Fast protein is not less stable or active at high temperatures, and Fast alleles increase ethanol tolerance and survivorship at all temperatures tested.
Title: Fitness effects but no temperature-mediated balancing selection at the polymorphic Adh gene of Drosophila melanogaster.
The introduction of optimal leucine codons led to an increase in ADH activity in third-instar larvae, consistent with translational selection for codon bias being stronger in the larval stage.
Title: Experimentally increased codon bias in the Drosophila Adh gene leads to an increase in larval, but not adult, alcohol dehydrogenase activity.
The translation mechanism of the dicistronic Adh-Adhr mRNA of Drosophila melanogaster, was investigated.
Title: The intergenic spacer of the Drosophila Adh-Adhr dicistronic mRNA stimulates internal translation initiation.
disruption of a conserved short-range pairing within Adh exon 2 has an effect on Adh expression
Title: Pleiotropic effect of disrupting a conserved sequence involved in a long-range compensatory interaction in the Drosophila Adh gene.
defects of mutations on intron splicing efficiency and alcohol dehydrogenase production
Title: Compensatory evolution of a precursor messenger RNA secondary structure in the Drosophila melanogaster Adh gene.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables acetaldehyde dehydrogenase (acetylating) activity	IDA Inferred from Direct Assay more info
enables alcohol dehydrogenase (NAD+) activity	IDA Inferred from Direct Assay more info	PubMed
enables alcohol dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info
enables alcohol dehydrogenase (NAD+) activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in NADH metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in acetaldehyde metabolic process	IMP Inferred from Mutant Phenotype more info
involved_in acetyl-CoA biosynthetic process from ethanol	IDA Inferred from Direct Assay more info
involved_in alcohol catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in alcohol metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in alcohol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in behavioral response to ethanol	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ethanol metabolic process	IMP Inferred from Mutant Phenotype more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: alcohol dehydrogenase

Names: ADH; Adh-PC; Adh-PE; Adh-PF; Adh-PH; Adh-PI; CG3481-PC; CG3481-PE; CG3481-PF; CG3481-PH; CG3481-PI; alcohol dehyrdrogenase; alcoholdehydrogenase; drosophila rhythmically expressed gene 1