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    TP63 tumor protein p63 [ Gallus gallus (chicken) ]

    Gene ID: 374269, updated on 10-Oct-2024

    Summary

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    Symbol
    TP63provided by CGNC
    Full Name
    tumor protein p63provided by CGNC
    Primary source
    CGNC:49111
    See related
    Ensembl:ENSGALG00010014867
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    TP73L; TRP63; deltaNp63; TAp63alpha
    Orthologs
    human mouse all
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    Genomic context

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    See TP63 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 9 NC_052540.1 (13741157..13844545, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 9 NC_052581.1 (13536717..13639950, complement)

    Chromosome 9 - NC_052540.1Genomic Context describing neighboring genes Neighboring gene claudin 1 Neighboring gene prolyl 3-hydroxylase 2 Neighboring gene uncharacterized LOC121111464 Neighboring gene uncharacterized LOC101751159 Neighboring gene uncharacterized LOC107054098

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identifying pathways regulating the oncogenic p53 family member ΔNp63 provides therapeutic avenues for squamous cell carcinoma. Pokorna Z, et al. Cell Mol Biol Lett, 2022 Feb 23. PMID 35196980, Free PMC Article
    2. TP63 Transcripts Play Opposite Roles in Chicken Skeletal Muscle Differentiation. Luo W, et al. Front Physiol, 2018. PMID 30283353, Free PMC Article
    3. The expression of p63 and Ck HMW in magnum and infundibulum of Gallus domesticus oviduct. Stadnicka K, et al. Folia Biol (Krakow), 2014. PMID 25403071
    4. Cloning and expression of the chick p63 gene. Yasue A, et al. Mech Dev, 2001 Jan. PMID 11118893
    5. Cell senescence, apoptosis and DNA damage cooperate in the remodeling processes accounting for heart morphogenesis. Lorda-Diez CI, et al. J Anat, 2019 Jun. PMID 30875434, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identifying pathways regulating the oncogenic p53 family member DeltaNp63 provides therapeutic avenues for squamous cell carcinoma.
      Title: Identifying pathways regulating the oncogenic p53 family member ΔNp63 provides therapeutic avenues for squamous cell carcinoma.
    2. Our analysis identified p63 as the most expressed member of the p53 gene family in areas of programmed cell death and senescence associated with the remodeling of the outflow tract to construct the roots of the great arteries and with septation of the cardiac cavities during the development of the heart in the chicken embryo.
      Title: Cell senescence, apoptosis and DNA damage cooperate in the remodeling processes accounting for heart morphogenesis.
    3. The expression of p63 in nuclei of luminal cells was significantly higher in the infundibulum, compared to the magnum section.
      Title: The expression of p63 and Ck HMW in magnum and infundibulum of Gallus domesticus oviduct.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein tetramerization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tumor protein 63
    Names
    DeltaNp63alpha
    transformation related protein 63

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398391.1 → NP_001385320.1  tumor protein 63 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000240
      UniProtKB/TrEMBL
      A0A3Q3A2R8
      Related
      ENSGALP00010020806.1, ENSGALT00010035868.1
      Conserved Domains (2) summary
      cd08367
      Location:138 → 319
      P53; P53 DNA-binding domain
      cd09572
      Location:504 → 568
      SAM_tumor-p63; SAM domain of tumor-p63 proteins

    2. NM_001398392.1 → NP_001385321.1  tumor protein 63 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000240
      UniProtKB/TrEMBL
      A0A3Q2TZ71
      Related
      ENSGALP00010020793.1, ENSGALT00010035854.1
      Conserved Domains (2) summary
      cd08367
      Location:138 → 319
      P53; P53 DNA-binding domain
      cd09572
      Location:500 → 564
      SAM_tumor-p63; SAM domain of tumor-p63 proteins

    3. NM_001398393.1 → NP_001385322.1  tumor protein 63 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000240
      UniProtKB/TrEMBL
      A0A167VDT2
      Related
      ENSGALP00010020797.1, ENSGALT00010035859.1
      Conserved Domains (3) summary
      cd08367
      Location:177 → 358
      P53; P53 DNA-binding domain
      cd09572
      Location:543 → 607
      SAM_tumor-p63; SAM domain of tumor-p63 proteins
      pfam07710
      Location:392 → 428
      P53_tetramer; P53 tetramerisation motif

    4. NM_001398394.1 → NP_001385323.1  tumor protein 63 isoform 7

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000240
      Conserved Domains (2) summary
      cd08367
      Location:77 → 258
      P53; P53 DNA-binding domain
      cd09572
      Location:439 → 503
      SAM_tumor-p63; SAM domain of tumor-p63 proteins

    5. NM_001398395.1 → NP_001385324.1  tumor protein 63 isoform 6

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000240
      Related
      ENSGALP00010020780.1, ENSGALT00010035834.1
      Conserved Domains (3) summary
      cd08367
      Location:77 → 258
      P53; P53 DNA-binding domain
      cd09572
      Location:443 → 507
      SAM_tumor-p63; SAM domain of tumor-p63 proteins
      pfam07710
      Location:292 → 328
      P53_tetramer; P53 tetramerisation motif

    6. NM_001398396.1 → NP_001385325.1  tumor protein 63 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000240
      UniProtKB/TrEMBL
      A0A167VDV3, F1NWD0
      Related
      ENSGALP00010020790.1, ENSGALT00010035848.1
      Conserved Domains (3) summary
      cd08367
      Location:83 → 264
      P53; P53 DNA-binding domain
      cd09572
      Location:449 → 513
      SAM_tumor-p63; SAM domain of tumor-p63 proteins
      pfam07710
      Location:298 → 334
      P53_tetramer; P53 tetramerisation motif

    7. NM_001398397.1 → NP_001385326.1  tumor protein 63 isoform 8

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000240
      Conserved Domains (1) summary
      cd08367
      Location:83 → 264
      P53; P53 DNA-binding domain

    8. NM_204351.2 → NP_989682.2  tumor protein 63 isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000240

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052540.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      13741157..13844545 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046898296.1 → XP_046754252.1  tumor protein 63 isoform X1

      UniProtKB/TrEMBL
      A0A167VDT2

    2. XM_046898297.1 → XP_046754253.1  tumor protein 63 isoform X2

      UniProtKB/TrEMBL
      A0A3Q3A2R8

    3. XM_046898299.1 → XP_046754255.1  tumor protein 63 isoform X4

    4. XM_046898298.1 → XP_046754254.1  tumor protein 63 isoform X3

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052581.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      13536717..13639950 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046923533.1 → XP_046779489.1  tumor protein 63 isoform X1

      UniProtKB/TrEMBL
      A0A167VDT2

    2. XM_046923535.1 → XP_046779491.1  tumor protein 63 isoform X5

      UniProtKB/TrEMBL
      A0A3Q2TZ71

    3. XM_046923534.1 → XP_046779490.1  tumor protein 63 isoform X2

      UniProtKB/TrEMBL
      A0A3Q3A2R8

    4. XM_046923537.1 → XP_046779493.1  tumor protein 63 isoform X4

    5. XM_046923536.1 → XP_046779492.1  tumor protein 63 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

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