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    mago mago nashi [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37402, updated on 18-Sep-2024

    Summary

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    Official Symbol
    magoprovided by FlyBase
    Official Full Name
    mago nashiprovided by FlyBase
    Primary source
    FLYBASE:FBgn0002736
    Locus tag
    Dmel_CG9401
    See related
    AllianceGenome:FB:FBgn0002736
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9401; Dm MGN; Dmel\CG9401; DmMago; l(2)57Ca; Mago; MAGO; Magoh; MAGOH; mgn; MGN
    Summary
    Involved in several processes, including negative regulation of transposition, DNA-mediated; oocyte microtubule cytoskeleton polarization; and regulation of pole plasm oskar mRNA localization. Located in nucleus and pole plasm. Part of exon-exon junction complex. Is expressed in several structures, including embryonic/larval midgut; embryonic/larval nervous system; extended germ band embryo; germ layer; and gonad. Orthologous to human MAGOHB (mago homolog B, exon junction complex subunit) and MAGOH (mago homolog, exon junction complex subunit). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See mago in Genome Data Viewer
    Location:
    57C2-57C2; 2-93 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21128577..21129737)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (17016082..17017242)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene king tubby Neighboring gene uncharacterized protein Neighboring gene Transmembrane O-mannosyltransferase targeting cadherins 3 Neighboring gene magi Neighboring gene uncharacterized protein Neighboring gene X box binding protein-1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutations in a newly identified Drosophila melanogaster gene, mago nashi, disrupt germ cell formation and result in the formation of mirror-image symmetrical double abdomen embryos. Boswell RE, et al. Development, 1991 Sep. PMID 1765008
    2. Crystal structure of the Drosophila Mago nashi-Y14 complex. Shi H, et al. Genes Dev, 2003 Apr 15. PMID 12704080, Free PMC Article
    3. Splicing of oskar RNA in the nucleus is coupled to its cytoplasmic localization. Hachet O, et al. Nature, 2004 Apr 29. PMID 15118729
    4. Molecular insights into the interaction of PYM with the Mago-Y14 core of the exon junction complex. Bono F, et al. EMBO Rep, 2004 Mar. PMID 14968132, Free PMC Article
    5. A novel mode of RBD-protein recognition in the Y14-Mago complex. Fribourg S, et al. Nat Struct Biol, 2003 Jun. PMID 12730685

    See all (148) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MAPK is the primary functional target of mago in eye development; in cultured cells, Mago knockdown disproportionately affects other large genes located in heterochromatin
      Title: Exon junction complex subunits are required to splice Drosophila MAP kinase, a large heterochromatic gene.
    2. Mago Nashi, Tsunagi/Y14, and Ranshi form a complex that influences oocyte differentiation in Drosophila melanogaster
      Title: Mago Nashi, Tsunagi/Y14, and Ranshi form a complex that influences oocyte differentiation in Drosophila melanogaster.
    3. mago nashi is required for germline stem cell differentiation, but surprisingly mago nashi functions independently of tsunagi/Y14 in this process
      Title: Mago Nashi and Tsunagi/Y14, respectively, regulate Drosophila germline stem cell differentiation and oocyte specification.
    4. We have determined the crystal structure of the complex between Drosophila melanogaster Y14 and Mago at a resolution of 2.5 A. The structure reveals an atypical mode of protein-protein recognition mediated by an RNA-binding domain (RBD).
      Title: A novel mode of RBD-protein recognition in the Y14-Mago complex.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in RNA splicing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in maintenance of pole plasm mRNA location TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in microtubule cytoskeleton organization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in oocyte microtubule cytoskeleton organization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in oocyte microtubule cytoskeleton polarization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pole plasm assembly TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in pole plasm oskar mRNA localization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in regulation of pole plasm oskar mRNA localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome HDA PubMed 
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of exon-exon junction complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of exon-exon junction complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of exon-exon junction complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in pole plasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of precatalytic spliceosome HDA PubMed 

    General protein information

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    Preferred Names
    mago nashi
    Names
    CG9401-PA
    mago nishi
    mago-PA
    mago-nashi

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      21128577..21129737
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057288.4 → NP_476636.1  mago nashi [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476636.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P49028, Q9W2L3
      UniProtKB/TrEMBL
      A0A023T5E7
      Related
      FBpp0071497
      Conserved Domains (1) summary
      cd11295
      Location:5 → 147
      Mago_nashi; Mago nashi proteins, integral members of the exon junction complex
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49028.1 P49028

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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