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    PSEN1 presenilin 1 [ Gallus gallus (chicken) ]

    Gene ID: 373977, updated on 10-Oct-2024

    Summary

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    Official Symbol
    PSEN1provided by CGNC
    Official Full Name
    presenilin 1provided by CGNC
    Primary source
    CGNC:7083
    See related
    Ensembl:ENSGALG00010020984
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    PS-1; presenilin-1
    Orthologs
    human mouse all
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    Genomic context

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    See PSEN1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 5 NC_052536.1 (25889584..25910988, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 5 NC_052577.1 (25856249..25877655, complement)

    Chromosome 5 - NC_052536.1Genomic Context describing neighboring genes Neighboring gene NUMB, endocytic adaptor protein Neighboring gene translation initiation factor IF-2-like Neighboring gene papilin, proteoglycan like sulfated glycoprotein Neighboring gene uncharacterized LOC121111006 Neighboring gene translation initiation factor IF-2-like Neighboring gene RNA binding motif protein 25 Neighboring gene zinc finger FYVE-type containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Assembly of the N-cadherin complex during synapse formation involves uncoupling of p120-catenin and association with presenilin 1. Rubio ME, et al. Mol Cell Neurosci, 2005 Sep. PMID 16046145
    2. Identification of the presenilins in hematopoietic cells with localization of presenilin 1 to neutrophil and platelet granules. Mirinics ZK, et al. Blood Cells Mol Dis, 2002 Jan-Feb. PMID 11987239
    3. Development and adaptations of innate immunity in the gastrointestinal tract of the newly hatched chick. Bar-Shira E, et al. Dev Comp Immunol, 2006. PMID 16430960
    4. Expressed sequence tag analysis of Eimeria-stimulated intestinal intraepithelial lymphocytes in chickens. Min W, et al. Mol Biotechnol, 2005 Jun. PMID 15920284
    5. A comprehensive collection of chicken cDNAs. Boardman PE, et al. Curr Biol, 2002 Nov 19. PMID 12445392

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The authors use expression of presenilin 1 to demonstrate that granulocytes complete functional maturation in gut
      Title: Development and adaptations of innate immunity in the gastrointestinal tract of the newly hatched chick.
    2. changes in the molecular composition of the N-cadherin complex (represented by the uncoupling of p120-catenin and association with PS1) may correspond to distinct functional states of the complex involved in synaptic maturation
      Title: Assembly of the N-cadherin complex during synapse formation involves uncoupling of p120-catenin and association with presenilin 1.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables aspartic endopeptidase activity, intramembrane cleaving IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables beta-catenin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables cadherin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Notch receptor processing IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in amyloid precursor protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in amyloid-beta metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in membrane protein ectodomain proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein processing IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in smooth endoplasmic reticulum calcium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Z disc IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in ciliary rootlet IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in dendritic shaft IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in growth cone IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane raft IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in neuromuscular junction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    presenilin-1
    NP_989494.2
    XP_015142400.1
    XP_040556470.1
    XP_040556472.1
    XP_046773584.1
    XP_046773585.1
    XP_046773586.1
    XP_046773587.1
    XP_046797300.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_204163.3 → NP_989494.2  presenilin-1

      See identical proteins and their annotated locations for NP_989494.2

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000214
      UniProtKB/Swiss-Prot
      Q4JIM4, Q90X08
      UniProtKB/TrEMBL
      A0A8V0ZGP0
      Related
      ENSGALP00010029949.1, ENSGALT00010050723.1
      Conserved Domains (1) summary
      pfam01080
      Location:77 → 458
      Presenilin

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052536.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      25889584..25910988 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040700536.2 → XP_040556470.1  presenilin-1 isoform X2

      UniProtKB/Swiss-Prot
      Q4JIM4, Q90X08
      UniProtKB/TrEMBL
      A0A8V0ZGP0
      Conserved Domains (1) summary
      pfam01080
      Location:77 → 458
      Presenilin

    2. XM_040700538.2 → XP_040556472.1  presenilin-1 isoform X2

      UniProtKB/Swiss-Prot
      Q4JIM4, Q90X08
      UniProtKB/TrEMBL
      A0A8V0ZGP0
      Conserved Domains (1) summary
      pfam01080
      Location:77 → 458
      Presenilin

    3. XM_046941344.1 → XP_046797300.1  presenilin-1 isoform X2

      UniProtKB/Swiss-Prot
      Q4JIM4, Q90X08

    4. XM_015286914.4 → XP_015142400.1  presenilin-1 isoform X1

      UniProtKB/TrEMBL
      A0A3Q2UE42, A0A8V0ZMP0
      Related
      ENSGALP00010029948.1, ENSGALT00010050722.1
      Conserved Domains (1) summary
      pfam01080
      Location:77 → 458
      Presenilin

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052577.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      25856249..25877655 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046917629.1 → XP_046773585.1  presenilin-1 isoform X2

      UniProtKB/Swiss-Prot
      Q4JIM4, Q90X08

    2. XM_046917631.1 → XP_046773587.1  presenilin-1 isoform X2

      UniProtKB/Swiss-Prot
      Q4JIM4, Q90X08

    3. XM_046917630.1 → XP_046773586.1  presenilin-1 isoform X2

      UniProtKB/Swiss-Prot
      Q4JIM4, Q90X08

    4. XM_046917628.1 → XP_046773584.1  presenilin-1 isoform X1

      UniProtKB/TrEMBL
      A0A3Q2UE42
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4JIM4.1 GenPept UniProtKB/Swiss-Prot:Q4JIM4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.