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    AHR1A aryl hydrocarbon receptor 1 alpha [ Gallus gallus (chicken) ]

    Gene ID: 373907, updated on 10-Oct-2024

    Summary

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    Official Symbol
    AHR1Aprovided by CGNC
    Official Full Name
    aryl hydrocarbon receptor 1 alphaprovided by CGNC
    Primary source
    CGNC:8232
    See related
    Ensembl:ENSGALG00010004433
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    AHR
    Orthologs
    human mouse all
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    Genomic context

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    See AHR1A in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 2 NC_052533.1 (28471720..28722202)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 2 NC_052574.1 (28504992..28755558)

    Chromosome 2 - NC_052533.1Genomic Context describing neighboring genes Neighboring gene basic leucine zipper and W2 domains 2 Neighboring gene tetraspanin 13 Neighboring gene anterior gradient 2, protein disulphide isomerase family member Neighboring gene anterior gradient 3, protein disulphide isomerase family member Neighboring gene uncharacterized LOC121109866 Neighboring gene sorting nexin 13 Neighboring gene uncharacterized LOC107052559

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evaluation of the Aryl Hydrocarbon Receptor Response in LMH 3D Spheroids. Sharin T, et al. Environ Toxicol Chem, 2020 Sep. PMID 32452045
    2. The molecular basis for differential dioxin sensitivity in birds: role of the aryl hydrocarbon receptor. Karchner SI, et al. Proc Natl Acad Sci U S A, 2006 Apr 18. PMID 16606854, Free PMC Article
    3. Towards molecular understanding of species differences in dioxin sensitivity: initial characterization of Ah receptor cDNAs in birds and an amphibian. Karchner SI, et al. Mar Environ Res, 2000 Jul-Dec. PMID 11460741
    4. Aryl hydrocarbon receptor activation by dioxin targets phosphoenolpyruvate carboxykinase (PEPCK) for ADP-ribosylation via 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible poly(ADP-ribose) polymerase (TiPARP). Diani-Moore S, et al. J Biol Chem, 2013 Jul 26. PMID 23770670, Free PMC Article
    5. Aryl hydrocarbon receptor activation leads to impairment of estrogen-driven chicken vitellogenin promoter activity in LMH cells. Bussmann UA, et al. Comp Biochem Physiol C Toxicol Pharmacol, 2013 Mar. PMID 23103859

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Evaluation of the Aryl Hydrocarbon Receptor Response in LMH 3D Spheroids.
      Title: Evaluation of the Aryl Hydrocarbon Receptor Response in LMH 3D Spheroids.
    2. Data indicate that aryl hydrocarbon receptor (AHR) enhances phosphoenolpyruvate carboxykinase (PEPCK) ADP-ribosylation through TiPARP TiPARP (TCDD-inducible poly(ADP-ribose) polymerase).
      Title: Aryl hydrocarbon receptor activation by dioxin targets phosphoenolpyruvate carboxykinase (PEPCK) for ADP-ribosylation via 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible poly(ADP-ribose) polymerase (TiPARP).
    3. Data show that hepatocellular carcinoma LMH cells transfected with a reporter construct bearing the vitellogenin promoter is a useful model for the study of hydrocarbon receptor (AHR)-estrogen receptor (ER) interaction in liver-derived cells.
      Title: Aryl hydrocarbon receptor activation leads to impairment of estrogen-driven chicken vitellogenin promoter activity in LMH cells.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables nuclear receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of aryl hydrocarbon receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    aryl hydrocarbon receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_204118.3 → NP_989449.3  aryl hydrocarbon receptor

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000036
      UniProtKB/TrEMBL
      Q9I9E2, Q9PTI7
      Related
      ENSGALP00010006052.1, ENSGALT00010010358.1
      Conserved Domains (3) summary
      cd11436
      Location:25 → 85
      bHLH-PAS_AhR; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor (AhR) and similar proteins
      pfam00989
      Location:113 → 183
      PAS; PAS fold
      pfam14598
      Location:286 → 390
      PAS_11; PAS domain

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      28471720..28722202
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046917049.1 → XP_046773005.1  aryl hydrocarbon receptor isoform X1

      UniProtKB/TrEMBL
      A0A8V0XH72

    2. XM_046917058.1 → XP_046773014.1  aryl hydrocarbon receptor isoform X1

      UniProtKB/TrEMBL
      A0A8V0XH72

    3. XM_046917054.1 → XP_046773010.1  aryl hydrocarbon receptor isoform X1

      UniProtKB/TrEMBL
      A0A8V0XH72

    4. XM_046917064.1 → XP_046773020.1  aryl hydrocarbon receptor isoform X1

      UniProtKB/TrEMBL
      A0A8V0XH72

    5. XM_046917035.1 → XP_046772991.1  aryl hydrocarbon receptor isoform X1

      UniProtKB/TrEMBL
      A0A8V0XH72

    6. XM_046917033.1 → XP_046772989.1  aryl hydrocarbon receptor isoform X1

      UniProtKB/TrEMBL
      A0A8V0XH72

    7. XM_046917047.1 → XP_046773003.1  aryl hydrocarbon receptor isoform X1

      UniProtKB/TrEMBL
      A0A8V0XH72

    8. XM_046917034.1 → XP_046772990.1  aryl hydrocarbon receptor isoform X1

      UniProtKB/TrEMBL
      A0A8V0XH72

    9. XM_046917043.1 → XP_046772999.1  aryl hydrocarbon receptor isoform X1

      UniProtKB/TrEMBL
      A0A8V0XH72

    10. XM_046917072.1 → XP_046773028.1  aryl hydrocarbon receptor isoform X1

      UniProtKB/TrEMBL
      A0A8V0XH72

    11. XM_046917068.1 → XP_046773024.1  aryl hydrocarbon receptor isoform X1

      UniProtKB/TrEMBL
      A0A8V0XH72

    12. XM_046917079.1 → XP_046773035.1  aryl hydrocarbon receptor isoform X1

      UniProtKB/TrEMBL
      A0A8V0XH72

    13. XM_046917081.1 → XP_046773037.1  aryl hydrocarbon receptor isoform X1

      UniProtKB/TrEMBL
      A0A8V0XH72

    14. XM_046917076.1 → XP_046773032.1  aryl hydrocarbon receptor isoform X1

      UniProtKB/TrEMBL
      A0A8V0XH72

    15. XM_046917084.1 → XP_046773040.1  aryl hydrocarbon receptor isoform X1

      UniProtKB/TrEMBL
      A0A8V0XH72

    16. XM_040674084.2 → XP_040530018.1  aryl hydrocarbon receptor isoform X1

      UniProtKB/TrEMBL
      A0A8V0XH72, Q9PTI7
      Conserved Domains (3) summary
      smart00091
      Location:134 → 197
      PAS; PAS domain
      pfam08447
      Location:318 → 400
      PAS_3; PAS fold
      cd11436
      Location:44 → 104
      bHLH-PAS_AhR; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor (AhR) and similar proteins

    17. XM_040674083.2 → XP_040530017.1  aryl hydrocarbon receptor isoform X1

      UniProtKB/TrEMBL
      A0A8V0XH72, Q9PTI7
      Related
      ENSGALP00010006055.1, ENSGALT00010010364.1
      Conserved Domains (3) summary
      smart00091
      Location:134 → 197
      PAS; PAS domain
      pfam08447
      Location:318 → 400
      PAS_3; PAS fold
      cd11436
      Location:44 → 104
      bHLH-PAS_AhR; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor (AhR) and similar proteins

    18. XM_040674085.2 → XP_040530019.1  aryl hydrocarbon receptor isoform X1

      UniProtKB/TrEMBL
      A0A8V0XH72, Q9PTI7
      Conserved Domains (3) summary
      smart00091
      Location:134 → 197
      PAS; PAS domain
      pfam08447
      Location:318 → 400
      PAS_3; PAS fold
      cd11436
      Location:44 → 104
      bHLH-PAS_AhR; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor (AhR) and similar proteins

    19. XM_046917092.1 → XP_046773048.1  aryl hydrocarbon receptor isoform X2

      Related
      ENSGALP00010006048.1, ENSGALT00010010351.1

    20. XM_040674087.2 → XP_040530021.1  aryl hydrocarbon receptor isoform X2

      UniProtKB/TrEMBL
      A0A8V0XJU6
      Conserved Domains (2) summary
      smart00091
      Location:42 → 105
      PAS; PAS domain
      pfam08447
      Location:226 → 308
      PAS_3; PAS fold

    21. XM_015281254.4 → XP_015136740.2  aryl hydrocarbon receptor isoform X3

      UniProtKB/TrEMBL
      A0A8V0XJV0
      Conserved Domains (1) summary
      pfam08447
      Location:144 → 226
      PAS_3; PAS fold

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052574.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      28504992..28755558
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046910155.1 → XP_046766111.1  aryl hydrocarbon receptor isoform X1

      UniProtKB/TrEMBL
      A0A8V0XH72

    2. XM_046910156.1 → XP_046766112.1  aryl hydrocarbon receptor isoform X1

      UniProtKB/TrEMBL
      A0A8V0XH72

    3. XM_046910160.1 → XP_046766116.1  aryl hydrocarbon receptor isoform X1

      UniProtKB/TrEMBL
      A0A8V0XH72

    4. XM_046910161.1 → XP_046766117.1  aryl hydrocarbon receptor isoform X1

      UniProtKB/TrEMBL
      A0A8V0XH72

    5. XM_046910158.1 → XP_046766114.1  aryl hydrocarbon receptor isoform X1

      UniProtKB/TrEMBL
      A0A8V0XH72

    6. XM_046910152.1 → XP_046766108.1  aryl hydrocarbon receptor isoform X1

      UniProtKB/TrEMBL
      A0A8V0XH72

    7. XM_046910149.1 → XP_046766105.1  aryl hydrocarbon receptor isoform X1

      UniProtKB/TrEMBL
      A0A8V0XH72

    8. XM_046910157.1 → XP_046766113.1  aryl hydrocarbon receptor isoform X1

      UniProtKB/TrEMBL
      A0A8V0XH72

    9. XM_046910151.1 → XP_046766107.1  aryl hydrocarbon receptor isoform X1

      UniProtKB/TrEMBL
      A0A8V0XH72

    10. XM_046910154.1 → XP_046766110.1  aryl hydrocarbon receptor isoform X1

      UniProtKB/TrEMBL
      A0A8V0XH72

    11. XM_046910150.1 → XP_046766106.1  aryl hydrocarbon receptor isoform X1

      UniProtKB/TrEMBL
      A0A8V0XH72

    12. XM_046910162.1 → XP_046766118.1  aryl hydrocarbon receptor isoform X1

      UniProtKB/TrEMBL
      A0A8V0XH72

    13. XM_046910159.1 → XP_046766115.1  aryl hydrocarbon receptor isoform X1

      UniProtKB/TrEMBL
      A0A8V0XH72

    14. XM_046910163.1 → XP_046766119.1  aryl hydrocarbon receptor isoform X1

      UniProtKB/TrEMBL
      A0A8V0XH72

    15. XM_046910165.1 → XP_046766121.1  aryl hydrocarbon receptor isoform X1

      UniProtKB/TrEMBL
      A0A8V0XH72

    16. XM_046910164.1 → XP_046766120.1  aryl hydrocarbon receptor isoform X1

      UniProtKB/TrEMBL
      A0A8V0XH72

    17. XM_046910167.1 → XP_046766123.1  aryl hydrocarbon receptor isoform X1

      UniProtKB/TrEMBL
      A0A8V0XH72

    18. XM_046910153.1 → XP_046766109.1  aryl hydrocarbon receptor isoform X1

      UniProtKB/TrEMBL
      A0A8V0XH72

    19. XM_046910168.1 → XP_046766124.1  aryl hydrocarbon receptor isoform X1

      UniProtKB/TrEMBL
      A0A8V0XH72

    20. XM_046910166.1 → XP_046766122.1  aryl hydrocarbon receptor isoform X1

      UniProtKB/TrEMBL
      A0A8V0XH72

    21. XM_046910169.1 → XP_046766125.1  aryl hydrocarbon receptor isoform X1

      UniProtKB/TrEMBL
      A0A8V0XH72

    22. XM_046910171.1 → XP_046766127.1  aryl hydrocarbon receptor isoform X2

    23. XM_046910170.1 → XP_046766126.1  aryl hydrocarbon receptor isoform X2

    24. XM_046910172.1 → XP_046766128.1  aryl hydrocarbon receptor isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

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