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    CG8950 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36921, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CG8950provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034186
    Locus tag
    Dmel_CG8950
    See related
    AllianceGenome:FB:FBgn0034186
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG8950
    Summary
    Predicted to be involved in transcription by RNA polymerase III. Predicted to be part of transcription factor TFIIIC complex. Is expressed in organism. Orthologous to human GTF3C3 (general transcription factor IIIC subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See CG8950 in Genome Data Viewer
    Location:
    53F3-53F4; 2-81 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17059331..17062634, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12946836..12950139, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene fat-spondin Neighboring gene teflon Neighboring gene Mov10 RISC complex RNA helicase Neighboring gene uncharacterized protein Neighboring gene snoRNA:Orphan CD box 17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Reduced Function of the Glutathione S-Transferase S1 Suppresses Behavioral Hyperexcitability in Drosophila Expressing Mutant Voltage-Gated Sodium Channels. Chen HL, et al. G3 (Bethesda), 2020 Apr 9. PMID 32054635, Free PMC Article
    2. Pausing of RNA polymerase II disrupts DNA-specified nucleosome organization to enable precise gene regulation. Gilchrist DA, et al. Cell, 2010 Nov 12. PMID 21074046, Free PMC Article
    3. Analysis of insect nuclear small heat shock proteins and interacting proteins. Moutaoufik MT, et al. Cell Stress Chaperones, 2021 Jan. PMID 32888179, Free PMC Article
    4. Identification of Drosophila mitotic genes by combining co-expression analysis and RNA interference. Somma MP, et al. PLoS Genet, 2008 Jul 18. PMID 18797514, Free PMC Article
    5. Genome features of "Dark-fly", a Drosophila line reared long-term in a dark environment. Izutsu M, et al. PLoS One, 2012. PMID 22432011, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in transcription by RNA polymerase III IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription by RNA polymerase III IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of transcription factor TFIIIC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG8950-PA
    CG8950-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      17059331..17062634 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259455.2 → NP_001246384.1  uncharacterized protein Dmel_CG8950, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246384.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JVW5
      Conserved Domains (4) summary
      COG0457
      Location:219 → 497
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:402 → 430
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:795 → 864
      TPR_12; Tetratricopeptide repeat
      pfam14559
      Location:448 → 510
      TPR_19; Tetratricopeptide repeat

    2. NM_137340.3 → NP_611184.1  uncharacterized protein Dmel_CG8950, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611184.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JVW5
      Related
      FBpp0086164
      Conserved Domains (4) summary
      COG0457
      Location:219 → 497
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:402 → 430
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:795 → 864
      TPR_12; Tetratricopeptide repeat
      pfam14559
      Location:448 → 510
      TPR_19; Tetratricopeptide repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JVW5 Q7JVW5

    Gene LinkOut

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