Gla galactosidase, alpha [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Glaprovided by RGD
Official Full Name: galactosidase, alphaprovided by RGD
Primary source: RGD:1589721
See related: EnsemblRapid:ENSRNOG00000011513 AllianceGenome:RGD:1589721
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables alpha-galactosidase activity and galactoside binding activity. Involved in several processes, including glycosphingolipid catabolic process; platelet aggregation; and regulation of axon diameter. Predicted to be located in Golgi apparatus; extracellular space; and lysosome. Predicted to be active in cytoplasm. Used to study Fabry disease and lysosomal storage disease. Human ortholog(s) of this gene implicated in Fabry disease. Orthologous to human GLA (galactosidase alpha). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 132.8), Kidney (RPKM 126.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq32

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (102062497..102073915, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (97769227..97780646, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (105405915..105417331, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Alpha-Galactosidase A-deficient develop cardiorenal phenotypes of Fabry disease.
Title: α-Galactosidase A-deficient rats accumulate glycosphingolipids and develop cardiorenal phenotypes of Fabry disease.

Submit: New GeneRIF Correction

General gene information

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Markers

RH140281 (e-PCR)
- UniSTS:222359

RH130891 (e-PCR)
- UniSTS:214175

BE118467 (e-PCR)
- UniSTS:248829

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables alpha-galactosidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables alpha-galactosidase activity	IDA Inferred from Direct Assay more info	PubMed
enables alpha-galactosidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables alpha-galactosidase activity	ISO Inferred from Sequence Orthology more info
enables catalytic activity	ISO Inferred from Sequence Orthology more info
enables galactoside binding	IDA Inferred from Direct Assay more info	PubMed
enables hydrolase activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within aorta development	ISO Inferred from Sequence Orthology more info
NOT acts_upstream_of_or_within bone mineralization	ISO Inferred from Sequence Orthology more info
involved_in glycoside catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycosphingolipid catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycosphingolipid catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glycosylceramide catabolic process	ISO Inferred from Sequence Orthology more info
involved_in lipid storage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of nitric-oxide synthase activity	ISO Inferred from Sequence Orthology more info
involved_in oligosaccharide metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in oligosaccharide metabolic process	ISO Inferred from Sequence Orthology more info
involved_in platelet activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in platelet aggregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of axon diameter	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of locomotion involved in locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sleep	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in lysosome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: alpha-galactosidase A

NP_001102290.2

EC 3.2.1.22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.