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    Zbtb48 zinc finger and BTB domain containing 48 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362668, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Zbtb48provided by RGD
    Official Full Name
    zinc finger and BTB domain containing 48provided by RGD
    Primary source
    RGD:1311581
    See related
    EnsemblRapid:ENSRNOG00000009595 AllianceGenome:RGD:1311581
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hkr3
    Summary
    Predicted to enable DNA-binding transcription factor activity; identical protein binding activity; and sequence-specific DNA binding activity. Predicted to be involved in positive regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; and telomere maintenance via telomere lengthening. Predicted to be located in chromosome, telomeric region. Orthologous to human ZBTB48 (zinc finger and BTB domain containing 48). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 64.7), Adrenal (RPKM 37.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zbtb48 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (167807965..167816332, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (162525234..162533604, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (169191771..169200140, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S25, pseudogene 9 Neighboring gene kelch-like family member 21 Neighboring gene taste 1 receptor member 1 Neighboring gene nucleolar protein 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. ZBTB48 is both a vertebrate telomere-binding protein and a transcriptional activator. Jahn A, et al. EMBO Rep, 2017 Jun. PMID 28500257, Free PMC Article
    2. TZAP: A telomere-associated protein involved in telomere length control. Li JS, et al. Science, 2017 Feb 10. PMID 28082411, Free PMC Article
    3. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC108933

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables double-stranded telomeric DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in telomere maintenance via telomere lengthening ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    telomere zinc finger-associated protein
    Names
    GLI-Kruppel family member HKR3
    zinc finger and BTB domain-containing protein 48

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013216.2 → NP_001013234.2  telomere zinc finger-associated protein

      See identical proteins and their annotated locations for NP_001013234.2

      Status: VALIDATED

      Source sequence(s)
      BC098691, BQ200912, CO567542
      UniProtKB/TrEMBL
      A0A8I5YBZ1, A6IUG1, G3V777
      Related
      ENSRNOP00000012745.3, ENSRNOT00000012745.7
      Conserved Domains (7) summary
      COG5048
      Location:458 → 519
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:369 → 454
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:462 → 482
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:404 → 420
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18232
      Location:8 → 115
      BTB_POZ_ZBTB48_TZAP_KR3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP)
      pfam00096
      Location:573 → 595
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:300 → 323
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      167807965..167816332 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039110449.1 → XP_038966377.1  telomere zinc finger-associated protein isoform X1

      Conserved Domains (4) summary
      sd00017
      Location:288 → 308
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18232
      Location:8 → 115
      BTB_POZ_ZBTB48_TZAP_KR3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP)
      pfam00096
      Location:629 → 651
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:300 → 323
      zf-H2C2_2; Zinc-finger double domain

    2. XM_039110450.2 → XP_038966378.1  telomere zinc finger-associated protein isoform X1

      Conserved Domains (4) summary
      sd00017
      Location:288 → 308
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18232
      Location:8 → 115
      BTB_POZ_ZBTB48_TZAP_KR3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP)
      pfam00096
      Location:629 → 651
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:300 → 323
      zf-H2C2_2; Zinc-finger double domain

    3. XM_006239469.5 → XP_006239531.1  telomere zinc finger-associated protein isoform X2

      See identical proteins and their annotated locations for XP_006239531.1

      UniProtKB/TrEMBL
      A0A8I5YBZ1, A6IUG1, G3V777
      Conserved Domains (7) summary
      COG5048
      Location:458 → 519
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:369 → 454
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:462 → 482
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:404 → 420
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18232
      Location:8 → 115
      BTB_POZ_ZBTB48_TZAP_KR3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP)
      pfam00096
      Location:573 → 595
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:300 → 323
      zf-H2C2_2; Zinc-finger double domain

    4. XM_039110451.2 → XP_038966379.1  telomere zinc finger-associated protein isoform X1

      Conserved Domains (4) summary
      sd00017
      Location:288 → 308
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18232
      Location:8 → 115
      BTB_POZ_ZBTB48_TZAP_KR3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP)
      pfam00096
      Location:629 → 651
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:300 → 323
      zf-H2C2_2; Zinc-finger double domain

    5. XM_063288093.1 → XP_063144163.1  telomere zinc finger-associated protein isoform X2

      UniProtKB/TrEMBL
      A6IUG1, G3V777

    6. XM_039110452.1 → XP_038966380.1  telomere zinc finger-associated protein isoform X3

      Conserved Domains (4) summary
      COG5048
      Location:168 → 229
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:79 → 164
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      COG5236
      Location:141 → 324
      COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      sd00017
      Location:172 → 192
      ZF_C2H2; C2H2 Zn finger [structural motif]

    7. XM_039110453.1 → XP_038966381.1  telomere zinc finger-associated protein isoform X4

      UniProtKB/TrEMBL
      Q5BK41
      Conserved Domains (3) summary
      sd00017
      Location:288 → 308
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18232
      Location:8 → 115
      BTB_POZ_ZBTB48_TZAP_KR3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP)
      pfam13465
      Location:300 → 323
      zf-H2C2_2; Zinc-finger double domain

    RNA

    1. XR_005504504.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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